Navigation Links
Celladon Corporation Receives Notice of Allowance from United States Patent and Trademark Office
Date:1/23/2013

relevant to our products and technologies on a global basis," finished Dr. Zsebo.

About Celladon's small molecule program

The initial focus of Celladon's SERCA small molecule program is the treatment of diabetes. It is now becoming recognized that obesity disrupts intracellular Ca2+ homeostasis and induces endoplasmic reticulum (ER) stress, leading to the accumulation of unfolded proteins in the ER. A high level of ER Ca2+ is imperative for maintenance of normal ER function and this high Ca2+ concentration of ER is maintained by sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA). Signs of ER stress have been found in liver and adipose tissue of obese mice and mice fed high-fat diets. Accumulating evidence suggests that ER stress plays a role in the pathogenesis of diabetes, contributing to pancreatic b-cell failure and insulin resistance. ER stress may also act as a link between obesity and insulin resistance in liver and adipose tissue, raising the intriguing possibility that the cellular ER stress response is a common mechanism for both b-cell dysfunction and defective insulin signaling in type 2 diabetes.

Celladon's novel approach is to develop pharmacological agents which correct this Ca2+ imbalance in the ER, via small molecule, allosteric SERCA2b agonists. These agents increase the Vmax of SERCA2b, increase Ca2+ content of the ER, effectively reduce the ER stress response, enhance glucose tolerance, and reduce hepatosteatosis.

About Celladon

Celladon is a privately held biotechnology company founded with the goal of becoming the leader in developing molecular therapies for the treatment of heart failure and cardiac diseases. The company's lead product, MYDICAR, targets the key enzyme deficiency in advanced heart failure, SERCA2a, which regulates calcium cycling and contractility in heart muscle cells. A recent Phase 2 clinical trial demonstrated sustained improvement at one year in cardiac function parameters and quality of
'/>"/>

SOURCE Celladon Corporation
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology news :

1. Medbox, Inc. Announces Top-Tier Rating by Dun & Bradstreet Credibility Corporation
2. ShanghaiBio Corporation Partners with Ingenuity Systems to Address Challenges in Analysis and Interpretation of Genomics Data
3. Eliza Corporation and BlueCross BlueShield of South Carolina Drive Awareness and Healthier Behavior to Increase Colorectal Cancer Screenings by 45 Percent
4. Statistics & Data Corporation Selects MedNet Solutions As Strategic Technology Partner
5. Sanford-Burnham and Intrexon Corporation establish collaboration to accelerate stem cell research
6. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
7. Renowned geneticist R. Rodney Howell receives ACMG Foundation Lifetime Achievement Award
8. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
9. Gladstone scientist Warner C. Greene receives Washington University School of Medicine Alumni Award
10. Carnegies Wolf B. Frommer receives Bogorad Award for Excellence in Plant Biology
11. UC Riverside plant cell biologist receives top scientific honor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... --  LaunchKey , the first decentralized mobile authentication and ... Things era, today announced the close of $3 million ... by Metamorphic Ventures with participation from ENIAC Ventures, Crosslink ... LaunchKey has raised $4 million to date, and will ... bring LaunchKey to market in 2015. LaunchKey ...
(Date:12/17/2014)... BELVOIR, Va. , Dec. 15, 2014 /PRNewswire-USNewswire/ ... efforts to make it easier to detect and ... chain. Today the agency started performing ... The capability will validate the authenticity of purchased ... chain. The new quality control measures will be ...
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, ... licensed its PerformTek biometric technology to industry leaders such ... highly accurate, clinically validated, biometric wearable products. These products ... 6-9 in Las Vegas . ... technology is accurate, flexible and robust – with the ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... Research from Case Western Reserve University School of Dental ... may hold the answer as to how human beta defensins ... and wreaking havoc with our healthcan be used to create ... linings on and in the body. Aaron Weinberg, professor ...
... Conference on Frontiers in Cancer Prevention Research will bring ... chemoprevention and lifestyle choices that may prevent cancer. As ... of cancer, researchers are turning to ways that cancer ... Oct. 22-25, 2011, in Boston, will feature hundreds of ...
... Oct. 2, 2011 A factor that is crucial for ... been discovered by a team of researchers from the Alexander ... Jerusalem and the Friedrich Miescher Institute for Biomedical Research in ... filamentous network is an essential element in this proper positioning, ...
Cached Biology News:Mother Nature's oral antibiotics research gets $2.25 million help from NIH 2Factor in keeping 'good order' of genes discovered 2
(Date:12/24/2014)... Island, New York (PRWEB) December 23, 2014 ... and the Long Island Affiliate of ITRA Global, the national ... slow but steady recovery. This is evidenced by the ... the strong stock market. Low energy costs have held ... The only negative is the housing market remaining soft. ...
(Date:12/24/2014)... 2014 China Biologic Products, Inc. (NASDAQ: ... fully integrated plasma-based biopharmaceutical company in ... subsidiary, Shandong Taibang Biological Products Co. Ltd., has ... China Food and Drug Administration (the "CFDA") for ... disclosed in the Company,s public filings, the CFDA ...
(Date:12/24/2014)... PARIS and NEW YORK ... data from its open-label pilot study of mazindol in ... Design, Development and Therapy in December 2014 . ... of mazindol in children with attention deficit/hyperactivity disorder" ( ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) ...
(Date:12/22/2014)... , Dec. 22, 2014 GenomeDx Biosciences today ... Prostate Cancer Classifier, a genomic test for prostate cancer, ... high-risk men managed by radical prostatectomy without adjuvant therapy. ... is relatively uncommon, using tumor genomics to identify these ... disease is an important advance. The study has been ...
Breaking Biology Technology:ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3
... Reserve University have taken the first step to building a ... engine or the sunny side of the planet Mercury. Te-Hao ... building blocks of circuits - that can take twice ... published in Science last month. The engineers took ...
... Oct. 7 MPM Capital, one of the world,s ... official opening of its Midwest office in Kansas City. ... the Unified Government of Wyandotte County and Kansas City, ... Kansas Bioscience Authority, were joined by numerous community, civic ...
... NASHVILLE, Tenn., Oct. 7 Cumberland Pharmaceuticals Inc. ... publication of data affirming the safety and efficacy ... in critically ill and non-critically ill adults. Published in ... showed that IV ibuprofen was significantly more effective at ...
Cached Biology Technology:New computer switches handle heat that renders transistors useless 2MPM Capital Opens Midwest Office 2Newly Published Caldolor® Clinical Data Demonstrates 77% Reduction in Fever in Hospitalized Patients 2Newly Published Caldolor® Clinical Data Demonstrates 77% Reduction in Fever in Hospitalized Patients 3Newly Published Caldolor® Clinical Data Demonstrates 77% Reduction in Fever in Hospitalized Patients 4
... which can immunocapture up to 50 g ... included are 2 mg of bovine heart ... immunocapture kit allows isolation of the ATP ... of tissue. This facilitates subsequent analysis of ...
ASCIZ...
Anti-Flavocytochrome b Monoclonal, FITC Labeled Research Focus: other Storage: 4C Shipping Temperature: 4C...
Chaps Cell Extract Buffer can be used to lyse cells under nondenaturing conditions and is recommendedfor the preparation of cell lysates to be used with our caspase signaling pathway antibodies...
Biology Products: