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Celladon Corporation Receives Notice of Allowance from United States Patent and Trademark Office
Date:1/23/2013

SAN DIEGO, Jan. 23, 2013 /PRNewswire/ -- Celladon Corporation, a biopharmaceutical company focused on the discovery and development of innovative treatments for cardiovascular diseases, announced today that the United States Patent and Trademark Office (USPTO) issued a notice of allowance for U.S. Patent Application No.: 13/145,787 with claims that cover methods for identifying compounds that modulate Sarco/Endoplamic Reticulum Calcium ATPase (SERCA) and methods for identifying compounds that modulate the SERCA/phospholamban complex using Celladon's proprietary fluorescence resonance energy transfer (FRET) assay.

The patent, titled "Fluorescence resonance energy transfer assays for sarco/endoplasmic reticulum calcium ATPase and phospholamban" is expected to issue later this year and is expected to provide a patent term to January, 2030. The inventor of the patent is Dr David D. Thomas of the University of Minnesota and is jointly owned by Celladon and the University of Minnesota. Celladon retains an exclusive license to use, develop, and commercialize this patent.

Using this proprietary FRET screening assay, Celladon has developed a broad platform of novel, first-in-class, small molecule allosteric modulators of the SERCA2b enzyme - generating drug candidates targeting diseases associated with ER stress-related pathways such as diabetes and neurodegenerative diseases. 

"This is a key patent allowance in Celladon's evolving patent portfolio covering our small molecule program targeting SERCA enzymes. The SERCA2b/ER stress pathway provides multiple opportunities for drug discovery and development in a number of disease areas with great unmet need.  This allowance further strengthens Celladon's leading position of generating active compounds in this emerging field" said Krisztina Zsebo Ph.D., President and CEO of Celladon Corp. "We will continue the pursuit of additional patents
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SOURCE Celladon Corporation
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