Navigation Links
Cell transplants may improve severe urinary incontinence
Date:11/12/2007

Tampa, Fla. (November 8, 2007) Estimates are that up to 70 million people worldwide may be suffering from severe urinary incontinence. A major cause of urinary incontinence is a deficiency of the urethral sphincter muscle, often associated with trauma during child birth, resulting from prostate surgery, or due to aging. According to a new study, those suffering from urethral sphincter muscle deficiency and resulting incontinence may eventually find relief through muscle cell transplants.

Researchers publishing in the current issue of CELL TRANSPLANTATION (Vol. 16 No. 7) discovered that when skeletal myoblasts - progenitor muscle cells with the potential to develop into muscle fiber - were transplanted into female rats suffering from urethral sphincter deficiency, the transplanted muscle cells helped increase urethral pressure, improving incontinence.

Self-renewing progenitor muscle cells can be cultivated in vitro, said Christophe Praud, PhD, of INSERMs Institut de Myologie, Universite Pierre et Marie Curie, Paris and lead author. When grafted into normal striated skeletal muscle they fuse with host muscle fibers where they can form mosaic fibers or regenerate new fibers.

In the double-blind study, self-donated (autologous) myoblast muscle cells were taken from the leg muscles of female laboratory rats and transplanted into their nerve-damaged and muscle-weakened sphincter muscles. A control group with the same urethral muscle deficiency received saline injections. When the grafted group was compared to the control group after 21 days, researchers found significant improvement in incontinence and measured near normal urethral closure pressures in the animals receiving the cell transplants.

Our results suggest that implanting myoblasts could be a potential innovative therapy for urethral deficiencies that lead to human incontinence, concluded Praud.


'/>"/>

Contact: Christophe Praud
c.praud@institut-myologie.org
33-142-165-712
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1

Related biology news :

1. LSU professors work to improve efficiency of ethanol fuel
2. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
3. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
4. Improved e-jet printing provides higher resolution and more versatility
5. MIT model could improve some drugs effectiveness
6. NIH awards UC $9 million grant to improve patient point-of-care technologies
7. In-vitro fertilization improved with 3-D/4-D-guided embryo transfer and new placement target
8. Stronger EPA leadership needed to improve water quality in Mississippi River
9. Exercise improves thinking, reduces diabetes risk in overweight children
10. Endobronchial valve significantly improves emphysema
11. Teamwork improves learning and career success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)... -- Rising sales of consumer electronics coupled ... gesture control market size through ... electronics coupled with new technological advancements to drive global ... through 2020   --> Rising ... to drive global touchfree intuitive gesture control market ...
(Date:1/27/2016)... WEST CHESTER, Ohio , Jan. 27, 2016 /PRNewswire/ ... services supplier based in West Chester, Ohio ... and their award winning service staff, based in ... Track,s technical capacity and ability to provide modifications, installations ... John Dovalina , CEO of PLUS, commented, "PLUS ...
(Date:1/22/2016)... 22, 2016 ... the "Global Biometrics Market in Retail ... --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has ... Biometrics Market in Retail Sector 2016-2020" ... Research and Markets ( http://www.researchandmarkets.com/research/p74whf/global_biometrics ) ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... ... February 11, 2016 , ... ... than 150 years, continues today to pursue the highest level of accuracy and ... instruments: the AR9 Refractometer and the AR5 Refractometer. Accurate, reliable and tough ...
(Date:2/10/2016)... 2016 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ), ... that Mitsui & Co. Ltd., its partner in the ... is investing an additional CDN$25 million in the joint ... from 30% to 40%.  Mitsui will also play a ... in Sarnia , providing dedicated resources ...
(Date:2/10/2016)... 2016 NX Prenatal Inc., a US ... technology for early warning of adverse pregnancy outcomes, ... study by Dr. Thomas McElrath of ... Fetal Medicine,s (SMFM) annual meeting held in ... 2016.  The presentation reported initial positive top-line results ...
(Date:2/10/2016)...  IsoRay, Inc. (NYSE MKT: ISR), a medical technology ... applications for the treatment of prostate, brain, lung, head ... results for the second quarter and six months of ... --> --> Revenue was ... which ended December 31, 2015, a 12% increase compared ...
Breaking Biology Technology: