Navigation Links
Cell transplants may improve severe urinary incontinence
Date:11/12/2007

Tampa, Fla. (November 8, 2007) Estimates are that up to 70 million people worldwide may be suffering from severe urinary incontinence. A major cause of urinary incontinence is a deficiency of the urethral sphincter muscle, often associated with trauma during child birth, resulting from prostate surgery, or due to aging. According to a new study, those suffering from urethral sphincter muscle deficiency and resulting incontinence may eventually find relief through muscle cell transplants.

Researchers publishing in the current issue of CELL TRANSPLANTATION (Vol. 16 No. 7) discovered that when skeletal myoblasts - progenitor muscle cells with the potential to develop into muscle fiber - were transplanted into female rats suffering from urethral sphincter deficiency, the transplanted muscle cells helped increase urethral pressure, improving incontinence.

Self-renewing progenitor muscle cells can be cultivated in vitro, said Christophe Praud, PhD, of INSERMs Institut de Myologie, Universite Pierre et Marie Curie, Paris and lead author. When grafted into normal striated skeletal muscle they fuse with host muscle fibers where they can form mosaic fibers or regenerate new fibers.

In the double-blind study, self-donated (autologous) myoblast muscle cells were taken from the leg muscles of female laboratory rats and transplanted into their nerve-damaged and muscle-weakened sphincter muscles. A control group with the same urethral muscle deficiency received saline injections. When the grafted group was compared to the control group after 21 days, researchers found significant improvement in incontinence and measured near normal urethral closure pressures in the animals receiving the cell transplants.

Our results suggest that implanting myoblasts could be a potential innovative therapy for urethral deficiencies that lead to human incontinence, concluded Praud.


'/>"/>

Contact: Christophe Praud
c.praud@institut-myologie.org
33-142-165-712
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1

Related biology news :

1. LSU professors work to improve efficiency of ethanol fuel
2. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
3. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
4. Improved e-jet printing provides higher resolution and more versatility
5. MIT model could improve some drugs effectiveness
6. NIH awards UC $9 million grant to improve patient point-of-care technologies
7. In-vitro fertilization improved with 3-D/4-D-guided embryo transfer and new placement target
8. Stronger EPA leadership needed to improve water quality in Mississippi River
9. Exercise improves thinking, reduces diabetes risk in overweight children
10. Endobronchial valve significantly improves emphysema
11. Teamwork improves learning and career success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2016)... March 29, 2016 LegacyXChange, Inc. ... "LEGX" and SelectaDNA/CSI Protect are pleased to announce our ... in a variety of writing instruments, ensuring athletes signatures ... created collectibles from athletes on LegacyXChange will be assured ... the DNA. Bill Bollander , CEO ...
(Date:3/18/2016)... --> --> Competitive Landscape Analysis ... Physical infrastructure and Perimeter Surveillance & Detection Systems ... and the continuing migration crisis in the Middle ... led visiongain to publish this unique report, which is crucial ... & security companies in the border security market and the ...
(Date:3/14/2016)... 14, 2016 http://www.apimages.com ) ... --> - Renvoi : image disponible via AP ... --> --> DERMALOG, le leader ... nouveaux lecteurs d,empreintes digitales pour l,enregistrement des réfugiés ... utilisé pour produire des cartes d,identité aux réfugiés. ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... ... to announce the appointment of John Tilton as Chief Commercial Officer.  Mr. Tilton ... one of the founding commercial leaders responsible for the commercialization of multiple orphan ...
(Date:4/27/2016)... ... April 27, 2016 , ... Global Stem Cells Group and ... Symposium as other research and development initiatives for potential stem cell protocol management for ... Stem Cells Group executives began meeting to establish a working agenda and foster initiatives ...
(Date:4/26/2016)... ... April 26, 2016 , ... The European Patent Office ... as one of three finalists for the European Inventor Award 2016 in the category ... will be announced at a ceremony in Lisbon on June 9th. , The human ...
(Date:4/26/2016)... ... 26, 2016 , ... Seattle based non-profit, The Institute for ... Corporation. The grant will be used to further the scientific research goals of ... http://www.ivsci.org , In accounting the grant to the IVS, Mr. Glenn ...
Breaking Biology Technology: