Navigation Links
Cell transplants may improve severe urinary incontinence
Date:11/12/2007

Tampa, Fla. (November 8, 2007) Estimates are that up to 70 million people worldwide may be suffering from severe urinary incontinence. A major cause of urinary incontinence is a deficiency of the urethral sphincter muscle, often associated with trauma during child birth, resulting from prostate surgery, or due to aging. According to a new study, those suffering from urethral sphincter muscle deficiency and resulting incontinence may eventually find relief through muscle cell transplants.

Researchers publishing in the current issue of CELL TRANSPLANTATION (Vol. 16 No. 7) discovered that when skeletal myoblasts - progenitor muscle cells with the potential to develop into muscle fiber - were transplanted into female rats suffering from urethral sphincter deficiency, the transplanted muscle cells helped increase urethral pressure, improving incontinence.

Self-renewing progenitor muscle cells can be cultivated in vitro, said Christophe Praud, PhD, of INSERMs Institut de Myologie, Universite Pierre et Marie Curie, Paris and lead author. When grafted into normal striated skeletal muscle they fuse with host muscle fibers where they can form mosaic fibers or regenerate new fibers.

In the double-blind study, self-donated (autologous) myoblast muscle cells were taken from the leg muscles of female laboratory rats and transplanted into their nerve-damaged and muscle-weakened sphincter muscles. A control group with the same urethral muscle deficiency received saline injections. When the grafted group was compared to the control group after 21 days, researchers found significant improvement in incontinence and measured near normal urethral closure pressures in the animals receiving the cell transplants.

Our results suggest that implanting myoblasts could be a potential innovative therapy for urethral deficiencies that lead to human incontinence, concluded Praud.


'/>"/>

Contact: Christophe Praud
c.praud@institut-myologie.org
33-142-165-712
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1

Related biology news :

1. LSU professors work to improve efficiency of ethanol fuel
2. Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction
3. Drug could improve pregnancy outcomes in wider range of women with insulin resistance
4. Improved e-jet printing provides higher resolution and more versatility
5. MIT model could improve some drugs effectiveness
6. NIH awards UC $9 million grant to improve patient point-of-care technologies
7. In-vitro fertilization improved with 3-D/4-D-guided embryo transfer and new placement target
8. Stronger EPA leadership needed to improve water quality in Mississippi River
9. Exercise improves thinking, reduces diabetes risk in overweight children
10. Endobronchial valve significantly improves emphysema
11. Teamwork improves learning and career success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... -- On Monday, the Department of Homeland Security (DHS) ... for the Biometric Exit Program. The Request for Information ... explains that CBP intends to add biometrics to confirm ... States , in order to deter visa overstays, ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... 20, 2016 Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring announced ... it has secured the final acceptance by all ... Managed Access Systems (MAS) installed. Furthermore, Securus will ... be installed by October, 2016. MAS distinguishes between ...
(Date:6/15/2016)... June 15, 2016 Transparency ... titled "Gesture Recognition Market by Application Market - Global Industry Analysis ... 2024". According to the report, the  global gesture recognition ... 2015 and is estimated to grow at a ... by 2024.  Increasing application of gesture ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016   Ginkgo Bioworks , a leading ... was today awarded as one of the World ... world,s most innovative companies. Ginkgo Bioworks is engineering ... real world in the nutrition, health and consumer ... with customers including Fortune 500 companies to design ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche ... with peritoneal or pleural mesothelioma. Their findings are the subject of a new article ... Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) is ... treatments and faster cures for prostate cancer. Members of the Class of 2016 ... countries. Read More About the Class of 2016 PCF ... ... ...
Breaking Biology Technology: