Navigation Links
Cell surface mutation protects against common type of malaria
Date:12/1/2011

They performed the genetic tests for the single-point mutation. Antigens with the mutation are called Duffy 'A' and those without, Duffy 'B'.

They found the parasite bound to red blood cells expressing Duffy 'B' about twice as often as the parasite bound to cells expressing Duffy 'A'.

The researchers wanted to see if the finding translated to real life.

They collaborated with Marcelo U. Ferreira, an investigator at the Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, to analyze data from 400 individuals tracked for malaria infections for more than a year in northwest Brazil.

In northwestern Brazil, where a mixture of Duffy 'A' and 'B' variants are inherited, the researchers found that people expressing the Duffy 'B' variant experience P. vivax malaria more often than those who expressed the Duffy 'A' variant.

"Therefore, stronger binding to Duffy 'B' leads to greater success at red cell invasion and more vivax malaria, Zimmerman said. "Seen from the other side of this relationship, weaker binding to Duffy 'A' appears to reduce red cell invasion and is therefore protective against vivax malaria."

The analysis showed that those with the Duffy 'A'/Duffy 'A' genotype had a 29 percent reduced risk of vivax malaria. Those who had the Duffy 'A'/Duffy 'B-negative' (a varient that has no antigen) genotype, had an 80 percent reduced risk. Reduced risk was not associated with an increase in antibodies in either case.

Those with Duffy 'B'/Duffy 'B' or Duffy 'B'/Duffy 'B-negative' genotypes had an increased risk of 220 to 270 percent for vivax malaria.

A vaccine's effectiveness therefore may depend on whether a recipient carries one or two copies of the Duffy 'A' or 'B' mutation in his DNA Dr. King said.

"The Duffy 'B' variant is ancestral to Duffy 'A'. We know this because all non-human primates carry the Duffy 'B' variant," Zimmerman said. "So a
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Surface tension drives segregation within cell mixtures
2. Surface-level ozone pollution set to reduce tree growth 10 percent by 2100
3. NIST-Cornell team builds worlds first nanofluidic device with complex 3-D surfaces
4. Sugar on bacteria surface serves as base for a web of resistance
5. EPAs new green parking lot allows scientists to study permeable surfaces that may help the environment
6. Multiple health concerns surface as winter, vitamin D deficiences arrive
7. Water may not run uphill, but it practically flies off new surface
8. 40 percent of surface disinfectants ineffective in eliminating viruses that cause gastroenteritis
9. Helping the NRC look below the surface
10. Invasive kudzu is major factor in surface ozone pollution, study shows
11. New model is proposed to explain absence of organic compounds on surface of Mars
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/3/2014)... and preterm birth are linked to increased risk for ... the American College of Rheumatology (ACR) journal, Arthritis ... and pre-term babies were not at greater risk of ... According to the ACR, 27 million Americans over the ... of OA range from mild to severe and include ...
(Date:11/2/2014)... 2014)—In support of a bold quest to rid the ... Foundation today announced an award of US$156 million to ... in building new vaccines that will interrupt the cycle ... to zero" agenda. Such vaccines would ensure that parasite ... an "immunological bed net." , This approach to ...
(Date:11/2/2014)... and bump into a biologist . . . , While ... sketch, researchers have taken this premise and applied it to ... in the rising oceans of genomic data. , In this ... studies are publishing at a dizzying rate. The challenge is ... the noise (and there is no shortage of noise). , ...
Breaking Biology News(10 mins):Preterm, low birth-weight babies may need new hips in adulthood 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 3New malaria vaccines to prevent infection and block transmission get a shot in the arm 4Mutant models 2Mutant models 3Mutant models 4
... have believed that eating large amounts of protein made it ... the winner of five consecutive Olympic wrestling championships in the ... he built his crushing strength in part by consuming 20 ... go to such extremes, but Milo,s legacy survives in the ...
... cells, which make up 45 percent of blood, normally take ... side. But they can sometimes deform into an asymmetrical slipper ... explore how fluid flow might be responsible for this deformation, ... flow. The insights could help understand the mechanisms involved in ...
... 26, 2009 Results of an important new study ... at the time of cataract surgery increases a nutritional ... the development and/or progression of age-related macular degeneration (AMD). ... from the Macular Pigment Research Group at the Waterford ...
Cached Biology News:Moderate amounts of protein per meal found best for building muscle 2Blue light-filtering increases macular pigment, may protect against age-related vision loss 2Blue light-filtering increases macular pigment, may protect against age-related vision loss 3Blue light-filtering increases macular pigment, may protect against age-related vision loss 4
(Date:11/26/2014)... PMG Research, Inc. announced today ... a network of sites that provide clinical research services to ... patient lives through its partnerships with large physician practices and ... site locations in the Southeastern United States and spans over ... board will be held by: Dr. Robert Holmes, ...
(Date:11/26/2014)... Continuing its award-winning streak, Nerium International, the leader ... for outstanding creative achievement by its marketing and communication ... organization’s top honor, in the Branding category for its ... of this year. The event showcased top speakers and ... awarded a Gold MarCom Award in the Special Events ...
(Date:11/26/2014)... MA (PRWEB) November 26, 2014 ... collaboration company is proud to announce that Darren Suders ... and Sales. Darren will drive the partner ... positive customer experience. , Darren brings more ... has held key roles in channel operations, from policy ...
(Date:11/26/2014)... Bio-Techne Corporation (NASDAQ: TECH ) ... to serve in a newly created position of ... Gavin will be responsible for managing the operations of ... business acquired in July 2014 and the recently acquired ... -based ProteinSimple develops and commercializes proprietary systems and ...
Breaking Biology Technology:PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2SoundConnect Appoints Director of Channel Development & Sales 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 3
... ,, A review of products for signal ... Activation of Signal Transduction Pathways with,PathDetect ... Mary Buchanan Chao-Feng Zheng ,Stratagene , ... such as,growth, differentiation, and coordination of cellular activities. ...
... streamlined and reliable method to obtain high-quality ... Basehore ,Stratagene , The StrataPrep ... quick, and reliable purification of bacteriophage single-stranded ... phage lysate exceeds the yield,obtained with the ...
... Preadipocytes and Differentiated Adipocytes ,,, A ... , Yuan-Di C. Halvorsen ,Zen-Bio, Inc. , ... , Regis Saladin , Ligand Pharmaceuticals ... , Stratagene introduces new tools to facilitate ...
Cached Biology Technology:Assess the In Vivo Activation of Signal Transduction Pathways with,PathDetect Reporting Systems 2Assess the In Vivo Activation of Signal Transduction Pathways with,PathDetect Reporting Systems 3Assess the In Vivo Activation of Signal Transduction Pathways with,PathDetect Reporting Systems 4Assess the In Vivo Activation of Signal Transduction Pathways with,PathDetect Reporting Systems 5Assess the In Vivo Activation of Signal Transduction Pathways with,PathDetect Reporting Systems 6Assess the In Vivo Activation of Signal Transduction Pathways with,PathDetect Reporting Systems 7Assess the In Vivo Activation of Signal Transduction Pathways with,PathDetect Reporting Systems 8Assess the In Vivo Activation of Signal Transduction Pathways with,PathDetect Reporting Systems 9Assess the In Vivo Activation of Signal Transduction Pathways with,PathDetect Reporting Systems 10Purified Single-Stranded M13 DNA for Automated Sequencing 2Purified Single-Stranded M13 DNA for Automated Sequencing 3Human Primary Preadipocytes and Differentiated Adipocytes 2Human Primary Preadipocytes and Differentiated Adipocytes 3Human Primary Preadipocytes and Differentiated Adipocytes 4Human Primary Preadipocytes and Differentiated Adipocytes 5Human Primary Preadipocytes and Differentiated Adipocytes 6