Navigation Links
Cell surface mutation protects against common type of malaria
Date:12/1/2011

They performed the genetic tests for the single-point mutation. Antigens with the mutation are called Duffy 'A' and those without, Duffy 'B'.

They found the parasite bound to red blood cells expressing Duffy 'B' about twice as often as the parasite bound to cells expressing Duffy 'A'.

The researchers wanted to see if the finding translated to real life.

They collaborated with Marcelo U. Ferreira, an investigator at the Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, to analyze data from 400 individuals tracked for malaria infections for more than a year in northwest Brazil.

In northwestern Brazil, where a mixture of Duffy 'A' and 'B' variants are inherited, the researchers found that people expressing the Duffy 'B' variant experience P. vivax malaria more often than those who expressed the Duffy 'A' variant.

"Therefore, stronger binding to Duffy 'B' leads to greater success at red cell invasion and more vivax malaria, Zimmerman said. "Seen from the other side of this relationship, weaker binding to Duffy 'A' appears to reduce red cell invasion and is therefore protective against vivax malaria."

The analysis showed that those with the Duffy 'A'/Duffy 'A' genotype had a 29 percent reduced risk of vivax malaria. Those who had the Duffy 'A'/Duffy 'B-negative' (a varient that has no antigen) genotype, had an 80 percent reduced risk. Reduced risk was not associated with an increase in antibodies in either case.

Those with Duffy 'B'/Duffy 'B' or Duffy 'B'/Duffy 'B-negative' genotypes had an increased risk of 220 to 270 percent for vivax malaria.

A vaccine's effectiveness therefore may depend on whether a recipient carries one or two copies of the Duffy 'A' or 'B' mutation in his DNA Dr. King said.

"The Duffy 'B' variant is ancestral to Duffy 'A'. We know this because all non-human primates carry the Duffy 'B' variant," Zimmerman said. "So a
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Surface tension drives segregation within cell mixtures
2. Surface-level ozone pollution set to reduce tree growth 10 percent by 2100
3. NIST-Cornell team builds worlds first nanofluidic device with complex 3-D surfaces
4. Sugar on bacteria surface serves as base for a web of resistance
5. EPAs new green parking lot allows scientists to study permeable surfaces that may help the environment
6. Multiple health concerns surface as winter, vitamin D deficiences arrive
7. Water may not run uphill, but it practically flies off new surface
8. 40 percent of surface disinfectants ineffective in eliminating viruses that cause gastroenteritis
9. Helping the NRC look below the surface
10. Invasive kudzu is major factor in surface ozone pollution, study shows
11. New model is proposed to explain absence of organic compounds on surface of Mars
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... American Society for Bone and Mineral Research awarded Michael ... Medicine (BUSM), with the 2014 Louis V. Avioli Award. ... BUSM, is internationally known for revolutionizing the understanding of ... , The award honors a member of the American ... contributions to bone and mineral basic research. It is ...
(Date:7/11/2014)... researchers from The Chinese University of Hong Kong, BGI ... soybean linked to salt tolerance, with implication for improving ... study published online in Nature Communications provides ... crop improvement. , Soybean is an important crop for ... soybeans have less genetic diversities than their wild counterparts. ...
(Date:7/11/2014)... 11, 2014 Researchers have pioneered a revolutionary ... new technology, called Virtual Finger, allows scientists to ... neurons and synapses using the flat surface of ... 3D imaging studies orders of magnitude more efficient, ... level across many areas of experimental biology. The ...
Breaking Biology News(10 mins):BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2BGI reports a novel gene for salt tolerance found in wild soybean 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... that remains unusually stable in the body, researchers at ... to the development of therapeutic RNA nanotechnology. Peixuan ... and professor of biomedical engineering, and his colleagues in ... construction of a thermodynamically stable RNA nanoparticle online in ...
... it turns out, suppresses melatonin 5 times more than exposure ... off an orange-yellow light. "Just as there are regulations and ... rules for the pollution stemming from artificial light at night," ... "White" light bulbs that emit light at shorter wavelengths ...
... Findings, published today in Nature and ... Pressure Genome-Wide Association Studies represent a major advance in our ... new potential therapeutic targets for prevention of heart disease and ... Research published in Nature and co-led by scientists ...
Cached Biology News:Team finds stable RNA nano-scaffold within virus core 2Dangers of exposure to 'white' light 2Dangers of exposure to 'white' light 3Discovery of blood pressure genes could help prevent cardiovascular disease 2Discovery of blood pressure genes could help prevent cardiovascular disease 3
(Date:7/11/2014)... , July 11, 2014 Research ... "International Transfection Technology Market - Global Industry Analysis, Size, ... to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... introduce nucleic acids (either DNA or RNA) into cells. ... mutation of cancer cells and protein metabolism by affecting ...
(Date:7/11/2014)... 2014  Researchers have pioneered a revolutionary new ... technology, called Virtual Finger, allows scientists to move ... and synapses using the flat surface of their ... imaging studies orders of magnitude more efficient, saving ... across many areas of experimental biology. The software ...
(Date:7/10/2014)... July 10, 2014 Deep Knowledge ... Medicine Forum on ‘Commercialising Longevity Research’ and welcomed ... to the London Bioscience Innovation Center for the ... and Aging Analytics Ltd. The meeting highlighted the ... translational research for age-related disease, as well as ...
(Date:7/10/2014)... Poway, CA (PRWEB) July 10, 2014 Robert ... Regenerative Veterinary Medicine company, is proud to announce the relaunch ... Pets, launching with a new series called “ What are ... to give an honest and straightforward foundation in the basics ... an educated decision on the right type of treatment when ...
Breaking Biology Technology:International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3
... July 31 InNexus,Biotechnology Inc., (TSX VENTURE: ... a drug development company commercializing the,next generation ... Cross Linking,(DXL(TM)) technology, will present at IBC,s ... of Innovative Therapeutics (DDT) Conference being,held in ...
... BERKELEY HEIGHTS, N.J., July 31 Genta,Incorporated (OTC ... release its second quarter 2008 financial results on ... conference call and live audio,webcast to discuss these ... Participants can access the live call by ...
... Amicus Therapeutics,(Nasdaq: FOLD ), a biopharmaceutical company ... of human,genetic diseases, will announce second quarter 2008 ... Thursday, August 7, 2008. The results,announcement will be ... that,afternoon at 5 p.m. EDT., Interested participants ...
Cached Biology Technology:InNexus Biotechnology CEO and Chief Scientific Officer to Present at IBC's Annual World Congress Conference in Boston on Aug 6th 2Genta Announces Second Quarter 2008 Financial Results and Conference Call 2Genta Announces Second Quarter 2008 Financial Results and Conference Call 3Amicus Therapeutics Announces Second Quarter 2008 Results Release Date 2
MOUSE ANTI HUMAN MBP (67-74) Immunogen: Human myelin basic protein...
NORMAL DONOR DONKEY SERUM...
... Molecular Probes Fc OxyBURST Green reagent (F-2902) ... of Boston University to permit measurement of ... and the subsequent oxidative burst directly in ... reagent consists of bovine serum albumin (BSA) ...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
Biology Products: