Navigation Links
Cell surface mutation protects against common type of malaria
Date:12/1/2011

A mutation on the surface of human red blood cells provides protection against malaria caused by the parasite Plasmodium vivax, research led by Case Western Reserve University School of Medicine shows.

The minute change, at a single position of red blood cell surface protein called the Duffy blood-group antigen, has been known for years. But the researchers found this difference makes it harder for the parasite to lock onto the cell and gain entry.

No entry, no infection.

The research is now published online in the Early Edition of the Proceedings of the National Academy of Sciences.

"The finding has practical implications as medical researchers continue attempts to develop a vaccine for vivax malaria," said Christopher King, a professor of international health, medicine and pathology at the Center for Global Health and Diseases at Case Western Reserve University School of Medicine, and lead author.

The protective aspect of the mutation was discovered in campus labs and confirmed through a population study in the Amazon region of Brazil.

Malaria is caused by four different parasites; the majority of cases in Asia and the Americas are caused by P. vivax.

"Plasmodium vivax carries a Duffy binding protein that binds to the Duffy antigen on the surface of the red cell, a critical step to invading the cell," Dr. King explained. "Both parasite and human proteins appear to be needed for the parasite to invade the cell."

King's lab had been studying the parasite's protein, as a target for a vaccine. He teamed with Peter A. Zimmerman, a professor of international health, genetics and biology, also at the Center for Global Health and Diseases. Zimmerman's lab was studying the mutation in the DNA sequence of Duffy blood group gene.

While investigating the binding process, they found that Duffy binding protein interaction with red blood cells varied between samples.


'/>"/>
Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Surface tension drives segregation within cell mixtures
2. Surface-level ozone pollution set to reduce tree growth 10 percent by 2100
3. NIST-Cornell team builds worlds first nanofluidic device with complex 3-D surfaces
4. Sugar on bacteria surface serves as base for a web of resistance
5. EPAs new green parking lot allows scientists to study permeable surfaces that may help the environment
6. Multiple health concerns surface as winter, vitamin D deficiences arrive
7. Water may not run uphill, but it practically flies off new surface
8. 40 percent of surface disinfectants ineffective in eliminating viruses that cause gastroenteritis
9. Helping the NRC look below the surface
10. Invasive kudzu is major factor in surface ozone pollution, study shows
11. New model is proposed to explain absence of organic compounds on surface of Mars
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ... the "Global Wearable Technologies Market and Applications, ... Trends and Forecast 2014-2020" report to their ... smart devices that can be worn on the ...
(Date:12/22/2014)... Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" or ... mobile commerce market, announces it has retained famous pickpocket, entertainer ... International CES debut of the Wocket™ biometric smart wallet.  ... NXT-ID booth January 6th and 7 th , 2015, demonstrating ...
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced the ... Security Systems Market" report to their offering. ... perimeter security market is estimated to grow at a CAGR ... holds a larger share in this market, Canada ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... to survive? The answer changes depending on climate, and some ... sprouts. Stanford researchers have found that the formation of ... meaning mouth) is controlled by a specific signaling pathway that ... The findings are described in a paper published Nov. 14 ...
... Nov. 24 M2SYS Technology, an award-winning,fingerprint ... that,InvoTech Systems Inc., the leading provider of ... industry, has chosen M2SYS Technology to,provide ... software and with M2SYS, M2-EasyScan(TM) optical fingerprint,reader. ...
... (NIST) announced today that it is awarding grants totaling ... cost-shared support for the construction of new scientific research ... in a special competition announced last spring. The ... the University of California at Berkeley for the build-out ...
Cached Biology News:Key link in how plants adapt to climate discovered by Stanford researchers 2InvoTech Selects M2SYS Technology for Leading-Edge Fingerprint Software Solution 2NIST awards $24M in grants for new research facilities 2NIST awards $24M in grants for new research facilities 3NIST awards $24M in grants for new research facilities 4NIST awards $24M in grants for new research facilities 5
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. (Nasdaq: ... focused on advanced wound care, announces that AMNIOEXCEL® ... have been added to the Premier, Inc. Regenerative ... opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product lines, ...
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. (NASDAQ: PTBI, ... announced the closing of an underwritten public offering of 3,500,000 ... an aggregate 3,500,000 shares of common stock, at an offering ... warrants have a per share exercise price of $5.00, are ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market ... (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, ... Forecasts to 2019” provides a detailed overview of ... trends, and strategies impacting the preparative and process ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... designed to introduce cutting edge communication technology, provide ... platform upgrades. This webinar series demonstrates online communication ... to leverage web conferencing’s most innovative and powerful ...
Breaking Biology Technology:Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... February 29, 2012 TREM Rx, Inc., a biotechnology ... to the skin, announced today the results of an in ... powerful cells of the immune system called TREMs (T Resident ... protective immune response that is far stronger than memory T ...
... has been shown to significantly improve the chances of pregnancy ... a Newcastle team of fertility experts at the University and ... a totally enclosed and controlled environment within which every step ... published today in the journal PLoS ONE reveals ...
... 2012 ARUP Laboratories, a leading national clinical and ... laboratory research and development, announced the establishment of a ... ) The new division is designed to ... enhance our ability to diversify into new market segments. ...
Cached Biology Technology:Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach 2Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach 3Increased fertility rate for IVF patients achieved by new equipment design 2ARUP Laboratories Announces Creation of Business Innovations Division 2
... The Gene Pulser Xcell eukaryotic ... 50-60 Hz, is used for ... system includes the main unit, ... microfarad range) or square-wave pulses, ...
... WinMelt software is used to ... any DNA sequence up to ... optimizing placement of primers and ... by denaturing gradient gel electrophoresis ...
AVOID FREEZE/THAW CYCLES. Recognizes the ~5 kDa thymosin beta4 protein....
... Services offer you a full range ... B-Bridges advanced design parameters, effective synthetic ... that you obtain quality results from ... Service utilizes their proprietary B-Algo algorithm ...
Biology Products: