Navigation Links
Cell signaling classification system gives researchers new tool
Date:7/2/2010

OAK RIDGE, Tenn., July 02, 2010 -- Using ever-growing genome data, scientists with the Department of Energy's (DOE) Oak Ridge National Laboratory and the University of Tennessee are tracing the evolution of the bacterial regulatory system that controls cellular motility, potentially giving researchers a method for predicting important cellular functions that will impact both medical and biotechnology research.

A new study from the Joint Institute for Computational Sciences, a research venture between ORNL and UT, has demonstrated how knowledge of biological systems can be derived by computational interrogation of genomic sequences. The results have implications for areas ranging from medicine to bioenergy.

"We now have hundreds of millions of DNA sequences from all sorts of organisms deposited in databases. However, our abilities to translate raw genomic data into useful knowledge are still very limited," said Igor Zhulin, joint faculty professor and principal investigator.

"We applied our computational skills to glean more information about a biological system that has fascinated researchers for more than a century. This is a molecular signal transduction system that allows bacteria to navigate in the environment pretty much in the same way that higher organisms, including humans, doby detecting signals (e.g., visual or chemical cues) and then moving toward favorable environments and away from dangerous ones."

In general, signal transduction systems in bacteria are very simple, consisting of only one or two proteins that regulate expression of various genes in response to changes in the environment. The navigation system, however, is significantly more complex and in some bacteria may involve dozens of different proteins.

How such complexity arose was unknown before this study, which has discovered intermediate signaling systems in bacteria that contain elements of both simple systems that regulate gene expressio
'/>"/>

Contact: Barbara Penland
penland@ornl.gov
865-574-4160
DOE/Oak Ridge National Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. New bacterial signaling molecule could lead to improved vaccines
2. Schizophrenia drugs raise the volume of a key signaling system in the brain
3. New cancer-fighting strategy focuses on signaling molecules
4. Disordered amino acids may really be there to provide wiggle room for signaling protein
5. Burnham researchers discover on switch for cell death signaling mechanism
6. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
7. Breast cancer treatment resistance linked to signaling pathway
8. Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway
9. MIT probe may help untangle cells signaling pathways
10. Proteins that stop a major signaling pathway can also generate new proteins
11. Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... Israel , May 6, 2015 LifeBEAM, ... most established helmet producer, announced today that they will ... Helmet, the world,s first bio-sensing cycling helmet and the ... released in two new colors in order to give ... the product. In addition, LifeBEAM and Lazer announced their ...
(Date:4/21/2015)... 21, 2015 High crime ... are boosting access control systems market in ... a recently published report by TechSci Research " Saudi ... access control systems market in Saudi Arabia ... 2020.The access control systems market in the Kingdom is ...
(Date:4/14/2015)... 14, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces that ... 2015 New York Design Awards under the category  ,Product ... City Design Awards are part of a global multi-disciplinary ... ratings from the marketplace, industry and judging panel. Winners ...
Breaking Biology News(10 mins):LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... WA This Christmas season, think twice about spending ... tree. The good, old-fashioned methodkeeping your tree in a ... keep your tree green and healthy. Researchers have determined ... trees; in fact, in several cases the chemical retardants ...
... Korea, December 12, 2008 The Western and Central ... reductions in fishing for bigeye and yellowfin tuna does ... World Wildlife Fund said today. The WCPFC disregarded the ... making this decision, which comes just a few weeks ...
... totalling 20m will be given to Bath, Imperial, London ... Strathclyde Universities as a result of the EPSRC 2008 ... partnership with Lancaster University have received a 5m grant ... of ,super carbon, discovered in the UK in 2004 ...
Cached Biology News:Flame retardants prove ineffective on fresh-cut Christmas trees 2Another fisheries commission throws the science overboard in tuna decision, WWF says 2EPSRC Science and Innovation Awards 2008 2EPSRC Science and Innovation Awards 2008 3EPSRC Science and Innovation Awards 2008 4
(Date:5/27/2015)... 27, 2015  US-Australian drug discovery and development company, Novogen ... it will present at the Brain Tumor Biotech Summit 2015, ... May 29, 2015. The venue is the Lennox Hill Hospital, ... The Brain Tumor Biotech Summit brings together ... and the investment community to promote innovative new therapies for ...
(Date:5/27/2015)... 27, 2015 ­ Caris Life Sciences®, a ... precision medicine, today announced it has appointed the Levine ... of excellence site in the Caris Centers of Excellence ... Cancer Institute is one of the largest cancer care ... new cancer patients annually. Derek Raghavan , M.D., ...
(Date:5/26/2015)... 26, 2015 WORMS, GERMANY – ... Co. (NYSE: GRA) announces that its manufacturing facility ... (GMP) certification from EXCiPACT™, an independent organization that ... , All three Grace facilities that ... excipient silica gels have now received GMP certification, ...
(Date:5/26/2015)... REDWOOD CITY, California and HILDEN, ... -- QIAGEN N.V. (NASDAQ: QGEN ... commercial launch of its QIAGEN Clinical Insight ® ... clinical testing labs to interpret and report on ... first two supported applications for the bioinformatics platform ...
Breaking Biology Technology:Novogen to Present at Brain Tumor Biotech Summit 2015 2Novogen to Present at Brain Tumor Biotech Summit 2015 3Novogen to Present at Brain Tumor Biotech Summit 2015 4Novogen to Present at Brain Tumor Biotech Summit 2015 5Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 2Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 3Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 4CORRECTION: Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 2QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 3QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 4QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 5
... Community...promotes entertainment everywhere on any device , ,MADISON, ... the sale of the companys desktop products group for ... transaction is now complete and Sony Pictures Digitals Executive ... keep the companys employee base in Madison and in ...
... become leader in alternative energy , ,Madison, WI ... purchase agreement with two developers that will build three ... produced in Wisconsin by 400%. , ,Under the agreement, ... Midwest Wind Energy, LLC, based in Chicago, will provide ...
... Build it, and they will come is an acceptable strategy ... diamond in an Iowa cornfield, but its not normally the ... team of partners in place, the La Crosse Health Science ... transfer Field of Dreams. , ,The $27 million, 168,000-square-foot center ...
Cached Biology Technology:Sony Completes Acquisition of Sonic Foundry 2Sony Completes Acquisition of Sonic Foundry 3WE Energies Is Not Letting Wind Power Blow Away 2La Crosse Health Science Center is an Evolving Example of Collaboration 2La Crosse Health Science Center is an Evolving Example of Collaboration 3
... six short years since publication of the ... widely acclaimed Protein Protocols Handbook, there have ... biochemistry. In recognition of the level of ... evolution of new methodologies directed to study ...
Kit for BASE20/50 dual control unit, includes mounting plate, HOLDER50T, HEATERPAD50, SRTDX temperature probe(s)....
... 10 nM is available for in ... described in: Z. Hassani, G.-F. Lemkine, P. ... and B.-A. Demeneix. Lipid-mediated siRNA delivery down ... brain at picomolar levels. J. Gene Med., ...
... The IHC Select Immunoperoxidase Secondary Detection ... rat or goat IgG in the Primary ... antigens present in the specimen. Any excess ... Secondary Antibody Reagent (conjugated to biotin) is ...
Biology Products: