Navigation Links
Cell receptor has proclivity for T helper 9 cells, airway inflammation
Date:7/29/2012

BOSTON, MAA research team led by Xian Chang Li, MD, PhD, Brigham and Women's Hospital (BWH) Transplantation Research Center, has shed light on how a population of lymphocytes, called CD4+ T cells, mature into various subsets of adult T helper cells. In particular, the team uncovered that a particular cell surface molecule, known as OX40, is a powerful inducer of new T helper cells that make copious amounts of interleukin-9 (IL-9) (and therefore called TH9 cells) in vitro; such TH9 cells are responsible for ongoing inflammation in the airways in the lungs in vivo.

The study will be published online in Nature Immunology on July 29, 2012.

In their studies, the researchers found that mice with hyper-active OX40 activities had signs of tissue inflammation, particularly in tissues lining the airway. A high amount of cellsas much as 30 percentin these tissues were mucin-producing cells. Mucin-producing cells produce gel-like secretions that, when combined with other secretions, can form mucus or saliva.

The results mirrored previous studies of mice who over expressed IL-9 in the lung airways. Results from additional experiments confirmed that OX40 triggers both TH9 cell and IL-9 production, thereby leading to airway inflammation.

"These findings may have broad impact on how to treat chronic inflammation, such as allergic inflammation and chronic allograft rejection after transplantation, since the inflammatory texture organized by TH9 cells tends to be different and ongoing." said Li.

In addition to this translational finding, Li and his team made strides in better understanding OX40's role in the molecular mechanisms of the pathway responsible for TH9 cell induction.

According to Li, the revelation that OX40 promotes TH9 cells through TRAF6 (a protein that mediates cell signaling) and the activation of a non-canonical NF-kB pathway will point to new opportunities in drug discovery and development in treatment of TH9-related diseases.


'/>"/>
Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
Source:Eurekalert

Related biology news :

1. Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management
2. G protein-coupled receptor mediates the action of castor oil
3. BUSM study identifies receptors role in regulating obesity, type 2 diabetes
4. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
5. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
6. Cystic fibrosis makes airways more acidic, reduces bacterial killing
7. New proteins to clear the airways in cystic fibrosis and COPD
8. Weight loss led to reduction in inflammation
9. Modest alcohol intake associated with less inflammation in patients with common liver disease
10. Intestinal bacteria produce neurotransmitter, could play role in inflammation
11. Omega-3 lowers inflammation in overweight older adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... -- Socionext Inc., a global expert in SoC-based imaging and computing solutions, ... which features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ... will be showcased during the upcoming Medtec Japan at Tokyo Big ... Las Vegas Convention Center April 24-27. ... Click here for an image of ...
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
Breaking Biology News(10 mins):
(Date:7/16/2017)... ... July 16, 2017 , ... OHAUS Corporation, ... the launch of its new line of Extreme Environment Shakers today. , Extreme ... CO2 and humidity for optimal cell growth such as cell cultures, solubility studies ...
(Date:7/14/2017)... ... July 14, 2017 , ... ... . Sonic Manufacturing Technologies has installed a solar system on its roof top. ... period,” the President of Sonic, Kenneth Raab stated. The company’s proud history of ...
(Date:7/14/2017)... Foreside, Maine (PRWEB) , ... July 13, 2017 ... ... VALIDATE® D-Dimer linearity and calibration verification test kit has received US FDA 510 ... kit, in a human plasma matrix, evaluates D-Dimer. Each VALIDATE® D-Dimer kit, prepared ...
(Date:7/13/2017)... ... July 13, 2017 , ... Thousands of pilots from across the ... National Aeromodeling Championships (Nats). Pilots come to Muncie to compete in various categories of ... US teams that participate in world championships. , RC Pylon (July 14-21): One of ...
Breaking Biology Technology: