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Cell on a chip reveals protein behavior
Date:3/18/2013

rface encoding a protein that can self-assemble into a nanotube. With the help of Dr. Sharon Wolf of the Electron Microscopy Unit, they observed a forest of minuscule tubes sprouting from the antibody area under an electron microscope.

The researchers then sought a way to produce and trap multiple proteins simultaneously by confining each protein in the area of its gene on the chip. On top of the chip to which the DNA encoding green proteins was bound, the scientists added a solution with a second gene encoding a red protein. The resulting red and green proteins competed for binding on the antibody traps, yielding a graded spatial separation in which the antibodies closest to the green genes had the highest concentration of green protein, with red concentrations rising farther afield. The results of this research recently appeared in Nature Nanotechnology.

Bar-Ziv: "We have shown that it is possible to build a protein "production line" outside of the cell and use it to observe a spectrum of protein activities." In the future, such a system may move from enabling the observation of proteins to providing the basis for techniques to create complex, active protein structures on demand.


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Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

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