Navigation Links
Cell-enriched fat grafts improve long term graft retention in preclinical study
Date:1/25/2010

SAN DIEGOResults from Cytori Therapeutics' (NASDAQ: CYTX) preclinical fat grafting study have been published in the February issue of the Annals of Plastic Surgery. This article, entitled "Supplementation of Fat Grafts with Adipose-Derived Regenerative Cells (ADRCs) Improves Long-Term Graft Retention," examines the science behind cell-enriched autologous fat grafting and its application to cosmetic and reconstructive surgery. The results demonstrate a doubling in graft retention in cell-enriched grafts and provide insight into the mechanisms behind this improvement. The results reinforce both commercial observations and interim data from the RESTORE 2 clinical study that was presented at the San Antonio Breast Cancer Symposium in December.

The preclinical results described in the paper support the potential clinical utility for cell-enriched fat grafts in cosmetic and reconstructive surgery. The key results include:

  • Long term retention of cell-enriched autologous fat grafts was increased two-fold over controls
  • Quality of the cell-enriched grafts was significantly higher than controls with an increased number of healthy fat cells and reduced formation of cysts
  • Improved blood vessel density in ADRC-enriched grafts
  • Demonstration of several critical growth factors expressed by ADRCs

In this study, a mouse model of autologous fat grafting was used to compare graft retention of cell-enriched fat grafts with traditional fat grafts. Retention was evaluated six and nine months after implantation. Supplemental in vitro and in vivo studies provide evidence that ADRC-enrichment improved graft retention and quality by promoting cell survival and the rapid formation of blood vessels within the graft through expression of growth factors known to promote vessel formation and prevent cell death.


'/>"/>

Contact: Megan McCormick
mmccormick@cytoritx.com
858-875-5279
Cytori Therapeutics
Source:Eurekalert

Page: 1

Related biology news :

1. Stent grafts: a better way to treat blunt trauma injuries
2. First evidence that blueberry juice improves memory in older adults
3. New research findings can improve avian flu surveillance programs
4. Study shows that delivering stem cells improves repair of major bone injuries in rats
5. Solar-powered irrigation significantly improves diet and income in rural sub-Saharan Africa
6. Observation about how nervous system learns and encodes motion could improve stroke recovery
7. Ford and MIT Team Up To Improve Safety by Reducing Driver Stress
8. New study finds catch shares improve consistency, not health, of fisheries
9. Researchers work on vaccine to improve immune system in newborns
10. Gas improves blood flow and organ status during minimally invasive surgery
11. Students learn environmental stewardship, improve science scores
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/3/2017)... 3, 2017  Data captured by IsoCode, ... detected a statistically significant association between the ... treatment and objective response of cancer patients ... predict whether cancer patients will respond to ... well as to improve both pre-infusion potency testing ...
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
(Date:3/24/2017)... Mar 24, 2017 Research and Markets has ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 15.1% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... ... Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. Representatives of ... award for Excellence in Volunteer Experience from US2020. , US2020’s mission is to ...
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced ... the NIH to develop RealSeq®-SC (Single Cell), expected to ... profiling small RNAs (including microRNAs) from single cells using ... highlights the need to accelerate development of approaches to ... "New techniques for measuring levels of ...
(Date:10/9/2017)...  BioTech Holdings announced today identification and patenting ... stem cell therapy prevents limb loss in animal ... that treatment with ProCell resulted in more than ... to standard bone marrow stem cell administration.  Interestingly, ... of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... The ... medical marijuana products targeting the needs of consumers who are incorporating medical marijuana ... place in Phoenix, Arizona. , As operators of two successful Valley dispensaries, The ...
Breaking Biology Technology: