Navigation Links
Cell-enriched fat grafts improve long term graft retention in preclinical study
Date:1/25/2010

SAN DIEGOResults from Cytori Therapeutics' (NASDAQ: CYTX) preclinical fat grafting study have been published in the February issue of the Annals of Plastic Surgery. This article, entitled "Supplementation of Fat Grafts with Adipose-Derived Regenerative Cells (ADRCs) Improves Long-Term Graft Retention," examines the science behind cell-enriched autologous fat grafting and its application to cosmetic and reconstructive surgery. The results demonstrate a doubling in graft retention in cell-enriched grafts and provide insight into the mechanisms behind this improvement. The results reinforce both commercial observations and interim data from the RESTORE 2 clinical study that was presented at the San Antonio Breast Cancer Symposium in December.

The preclinical results described in the paper support the potential clinical utility for cell-enriched fat grafts in cosmetic and reconstructive surgery. The key results include:

  • Long term retention of cell-enriched autologous fat grafts was increased two-fold over controls
  • Quality of the cell-enriched grafts was significantly higher than controls with an increased number of healthy fat cells and reduced formation of cysts
  • Improved blood vessel density in ADRC-enriched grafts
  • Demonstration of several critical growth factors expressed by ADRCs

In this study, a mouse model of autologous fat grafting was used to compare graft retention of cell-enriched fat grafts with traditional fat grafts. Retention was evaluated six and nine months after implantation. Supplemental in vitro and in vivo studies provide evidence that ADRC-enrichment improved graft retention and quality by promoting cell survival and the rapid formation of blood vessels within the graft through expression of growth factors known to promote vessel formation and prevent cell death.


'/>"/>

Contact: Megan McCormick
mmccormick@cytoritx.com
858-875-5279
Cytori Therapeutics
Source:Eurekalert

Page: 1

Related biology news :

1. Stent grafts: a better way to treat blunt trauma injuries
2. First evidence that blueberry juice improves memory in older adults
3. New research findings can improve avian flu surveillance programs
4. Study shows that delivering stem cells improves repair of major bone injuries in rats
5. Solar-powered irrigation significantly improves diet and income in rural sub-Saharan Africa
6. Observation about how nervous system learns and encodes motion could improve stroke recovery
7. Ford and MIT Team Up To Improve Safety by Reducing Driver Stress
8. New study finds catch shares improve consistency, not health, of fisheries
9. Researchers work on vaccine to improve immune system in newborns
10. Gas improves blood flow and organ status during minimally invasive surgery
11. Students learn environmental stewardship, improve science scores
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... Czech Republic , February 8, 2016 /PRNewswire/ ... EU-regulated global payment platform which presents innovation for ... Biometrics Authentication feature called VoiceKey. --> ... platform which presents innovation for clients, comfort and ... called VoiceKey. --> Worldcore ...
(Date:2/4/2016)... -- The field of Human Microbiome research and ... hubs of the biotechnology industry. While the Human ... human microbiota, have garnered a lot of attention ... has literally exploded in terms of both basic ... on biomedical aspects of research, development, and commercial ...
(Date:2/3/2016)... -- --> --> ... Identification System Market by Component (Hardware and Software), Search ... Government, Healthcare, and Transportation) and Geography - Global Forecast ... to be worth USD 8.49 Billion by 2020 at ... The transformation and technology evolution from the manual process ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... 10, 2016  IsoRay, Inc. (NYSE MKT: ISR), a ... medical radioisotope applications for the treatment of prostate, brain, ... its financial results for the second quarter and six ... --> --> ... fiscal 2016, which ended December 31, 2015, a 12% ...
(Date:2/10/2016)... Texas (PRWEB) , ... February 10, 2016 , ... ... centers across three states, announced today the promotion of two long-standing principal investigators ... Chief of Family Medicine, Clinical Research and Development. , Dr. Laurence Chu, a ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... their comprehensive training and support program, Sonalinkā„¢ remote monitoring. The inaugural launch of ... on Friday, February 5th, connecting Dr. Samuel Peretsman to a HIFU technical expert ...
(Date:2/10/2016)... ... 10, 2016 , ... Global Stem Cells Group, ... Global Stem Cells Network (GSCN) and its affiliate Global Medical Training Network ... adipose and bone marrow therapies. , Through the new collaboration, Global Stem ...
Breaking Biology Technology: