Navigation Links
Cell division finding could boost understanding of cancer
Date:2/3/2014

New insights into how the cells in our bodies divide could improve our knowledge of a condition linked to cancer, a study suggests.

Errors in the cell division process which allows us to grow and stay healthy can lead to a genetic disorder called aneuploidy, which is also associated with birth defects and infertility.

Researchers at the University of Edinburgh have pinpointed the key role played by a protein in ensuring that cells separate correctly.

During cell division, chromosomes containing our DNA duplicate and then separate to form two identical copies of the original cell. Aneuploidy arises when chromosome pairs fail to separate properly.

Scientists say that a protein called shugoshin serves two important functions. It recruits other parts of the cell which are needed for chromosome separation and enables an in-built error correction system to monitor cells as they divide.

Researchers studied the effect that disabling shugoshin had on cell division in yeast. The team found that in the absence of a working shugoshin protein, cells were more likely to contain abnormal numbers of chromosomes.

Cell division in yeast is very similar to that of humans, making it an excellent model in which to study the role that shugoshin plays in preventing aneuploidy in people.

The study, published in the journal eLife, was funded by the Wellcome Trust, the European Molecular Biology Organisation, the Scottish Universities Life Sciences Alliance and the Darwin Trust of Edinburgh.

Dr Adele Marston, of the University of Edinburgh's School of Biological Sciences, who led the study, said: "Faults in these proteins are linked to some types of cancer, and our new discoveries about how they function in yeast could help us understand how they can sometimes contribute to disease in humans."


'/>"/>

Contact: Catriona Kelly
Catriona.Kelly@ed.ac.uk
44-131-651-4401
University of Edinburgh
Source:Eurekalert

Page: 1

Related biology news :

1. New key mechanism in cell division discovered
2. American Association for the Advancement of Science - Pacific Division convenes in Boise June 24-27
3. BWH launches a new research division focused on integrating systems biology and medicine
4. Division of labor offers insight into the evolution of multicellular life
5. IdentiSys acquires the Identification, Security and Presentation Divisions of Mountainland Business Systems, a Utah based reseller
6. Chromosome anchors organize DNA during cell division
7. Molecular forces are key to proper cell division
8. New insight into double-protected dance of cell division
9. Discovery of cell division master controller may improve understanding and treatment of cancer
10. Division of labor in the test tube
11. SourceMedical Announces Hiring of Clinical Expert for ASC Division
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/11/2016)... 11, 2016 --> ... report "Image Recognition Market by Technology (Pattern Recognition), by ... by Deployment Type (On-Premises and Cloud), by Industry Vertical ... by MarketsandMarkets, the global market is expected to grow ... Billion by 2020, at a CAGR of 19.1%. ...
(Date:3/10/2016)... --  Unisys Corporation (NYSE: UIS ) today announced ... testing its biometric identity solution at the Otay Mesa border ... identify certain non-U.S. citizens leaving the country. ... determine the efficiency and accuracy of using biometric technologies in ... until May 2016. --> the United States ...
(Date:3/9/2016)... Nigeria . Recently, ... 23,000 public service employees either did not exist with ... unlawfully.    --> Nigeria . ... than 23,000 public service employees either did not exist ... salary unlawfully.    --> DERMALOG, the biometrics ...
Breaking Biology News(10 mins):
(Date:5/6/2016)... Reno, NV (PRWEB) , ... May 06, 2016 ... ... today that their most recent release, Clinical Studio Version 4.1, greatly improves performance ... as in oncology, where protocols often generate tremendous volumes of data to be ...
(Date:5/5/2016)... ... May 05, 2016 , ... American Process, Inc. (API) announced ... Patent Nos. 9,322,133 and 9,322,134, to API and its affiliated companies for BioPlus® ... hydrophobic nanocellulose compositions. In addition to these patents and U.S. Patent No. ...
(Date:5/4/2016)... ... May 05, 2016 , ... CereScan, the ... National Stroke Association during National Stroke Awareness Month in May. An infographic ... throughout the month. CereScan will donate $1 up to a maximum of ...
(Date:5/4/2016)... May 4, 2016  Bayer today announced that ... Stivarga ® (regorafenib) tablets for the treatment ... met its primary endpoint of a statistically significant ... evaluated the efficacy and safety of regorafenib in ... treatment with sorafenib. The safety and tolerability were ...
Breaking Biology Technology: