Navigation Links
Cell division finding could boost understanding of cancer
Date:2/3/2014

New insights into how the cells in our bodies divide could improve our knowledge of a condition linked to cancer, a study suggests.

Errors in the cell division process which allows us to grow and stay healthy can lead to a genetic disorder called aneuploidy, which is also associated with birth defects and infertility.

Researchers at the University of Edinburgh have pinpointed the key role played by a protein in ensuring that cells separate correctly.

During cell division, chromosomes containing our DNA duplicate and then separate to form two identical copies of the original cell. Aneuploidy arises when chromosome pairs fail to separate properly.

Scientists say that a protein called shugoshin serves two important functions. It recruits other parts of the cell which are needed for chromosome separation and enables an in-built error correction system to monitor cells as they divide.

Researchers studied the effect that disabling shugoshin had on cell division in yeast. The team found that in the absence of a working shugoshin protein, cells were more likely to contain abnormal numbers of chromosomes.

Cell division in yeast is very similar to that of humans, making it an excellent model in which to study the role that shugoshin plays in preventing aneuploidy in people.

The study, published in the journal eLife, was funded by the Wellcome Trust, the European Molecular Biology Organisation, the Scottish Universities Life Sciences Alliance and the Darwin Trust of Edinburgh.

Dr Adele Marston, of the University of Edinburgh's School of Biological Sciences, who led the study, said: "Faults in these proteins are linked to some types of cancer, and our new discoveries about how they function in yeast could help us understand how they can sometimes contribute to disease in humans."


'/>"/>

Contact: Catriona Kelly
Catriona.Kelly@ed.ac.uk
44-131-651-4401
University of Edinburgh
Source:Eurekalert

Page: 1

Related biology news :

1. New key mechanism in cell division discovered
2. American Association for the Advancement of Science - Pacific Division convenes in Boise June 24-27
3. BWH launches a new research division focused on integrating systems biology and medicine
4. Division of labor offers insight into the evolution of multicellular life
5. IdentiSys acquires the Identification, Security and Presentation Divisions of Mountainland Business Systems, a Utah based reseller
6. Chromosome anchors organize DNA during cell division
7. Molecular forces are key to proper cell division
8. New insight into double-protected dance of cell division
9. Discovery of cell division master controller may improve understanding and treatment of cancer
10. Division of labor in the test tube
11. SourceMedical Announces Hiring of Clinical Expert for ASC Division
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... YORK , March 2, 2017 Summary ... better understand Perrigo and its partnering interests and activities since ... ... Partnering Deals and Alliance since 2010 report provides an in-depth ... leading life sciences companies. On demand company reports ...
(Date:3/2/2017)... 2017 Australian stem cell and regenerative medicine ... signed an agreement with the Monash Lung Biology Network, ... Institute and Department of Pharmacology at Monash University, ... study to support the use of Cymerus™ mesenchymal stem ... Asthma is a chronic, long term lung condition ...
(Date:2/28/2017)... , February 28, 2017 News solutions ... ... Amsterdam from 14 to 16 March, Materna will ... and show how seamless travel is a real benefit for passengers. ... added biometrics to their passenger touch point solutions to take passengers ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... , March 29, 2017 "Surging application ... deployed by the government are expected to drive the ... The gesture recognition market is expected to be ... CAGR of 29.63% between 2017 and 2022. The touchless ... billion by 2022, growing at a CAGR of 17.44% ...
(Date:3/29/2017)... , March 29, 2017 WuXi Biologics, ... company dedicated to biologics and a WuXi AppTec ... 2017 Asia-Pacific Best Bioprocessing Excellence Award from IMAPAC, ... Excellence Awards aims to recognize outstanding leaders and ... Featuring top bioprocessing and biomanufacturing experts in the ...
(Date:3/29/2017)... (PRWEB) , ... March 29, 2017 , ... ... to announce that Nerium International Mexico has been approved as an active member ... to achieve satisfaction and protection among distributers and consumers in relationship marketing. This ...
(Date:3/29/2017)... 2017  Applied BioMath ( www.appliedbiomath.com ), ... drug research and development, today announced an ... for quantitative systems pharmacology (QSP) support for ... treatment of cancer. Applied ... toxicology studies and first-in-human dose predictions for ...
Breaking Biology Technology: