Navigation Links
Cell division finding could boost understanding of cancer
Date:2/3/2014

New insights into how the cells in our bodies divide could improve our knowledge of a condition linked to cancer, a study suggests.

Errors in the cell division process which allows us to grow and stay healthy can lead to a genetic disorder called aneuploidy, which is also associated with birth defects and infertility.

Researchers at the University of Edinburgh have pinpointed the key role played by a protein in ensuring that cells separate correctly.

During cell division, chromosomes containing our DNA duplicate and then separate to form two identical copies of the original cell. Aneuploidy arises when chromosome pairs fail to separate properly.

Scientists say that a protein called shugoshin serves two important functions. It recruits other parts of the cell which are needed for chromosome separation and enables an in-built error correction system to monitor cells as they divide.

Researchers studied the effect that disabling shugoshin had on cell division in yeast. The team found that in the absence of a working shugoshin protein, cells were more likely to contain abnormal numbers of chromosomes.

Cell division in yeast is very similar to that of humans, making it an excellent model in which to study the role that shugoshin plays in preventing aneuploidy in people.

The study, published in the journal eLife, was funded by the Wellcome Trust, the European Molecular Biology Organisation, the Scottish Universities Life Sciences Alliance and the Darwin Trust of Edinburgh.

Dr Adele Marston, of the University of Edinburgh's School of Biological Sciences, who led the study, said: "Faults in these proteins are linked to some types of cancer, and our new discoveries about how they function in yeast could help us understand how they can sometimes contribute to disease in humans."


'/>"/>

Contact: Catriona Kelly
Catriona.Kelly@ed.ac.uk
44-131-651-4401
University of Edinburgh
Source:Eurekalert

Page: 1

Related biology news :

1. New key mechanism in cell division discovered
2. American Association for the Advancement of Science - Pacific Division convenes in Boise June 24-27
3. BWH launches a new research division focused on integrating systems biology and medicine
4. Division of labor offers insight into the evolution of multicellular life
5. IdentiSys acquires the Identification, Security and Presentation Divisions of Mountainland Business Systems, a Utah based reseller
6. Chromosome anchors organize DNA during cell division
7. Molecular forces are key to proper cell division
8. New insight into double-protected dance of cell division
9. Discovery of cell division master controller may improve understanding and treatment of cancer
10. Division of labor in the test tube
11. SourceMedical Announces Hiring of Clinical Expert for ASC Division
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... 2017 The report "Video Surveillance ... Servers, Storage Devices), Software (Video Analytics, VMS), and Service ... Forecast to 2022", published by MarketsandMarkets, the market was ... projected to reach USD 75.64 Billion by 2022, at ... base year considered for the study is 2016 and ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by ... Global Forecast to 2022", published by MarketsandMarkets, the market is expected to be ... 2017 and 2022. Continue Reading ... ... ...
(Date:3/22/2017)... 2017 Vigilant Solutions , a vehicle ... agencies, announced today the appointment of retired FBI special ... safety business development. Mr. Sheridan brings more ... a focus on the aviation transportation sector, to his ... Mr. Sheridan served as the Aviation Liaison Agent Coordinator ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... , ... July 20, 2017 , ... Corporate Directors Forum ... its 27th annual Director of the Year Awards. , The awards will be presented ... This annual event celebrates directors who have made significantly positive contributions in the ...
(Date:7/18/2017)... (PRWEB) , ... July 18, 2017 , ... ... from the United States Patent and Trademark Office for its Patent Applications 14/858,857 ... Trademark Office’s allowances of these patent applications further expand the protection of G-CON’s ...
(Date:7/17/2017)... ... July 17, 2017 , ... The Academy of Model Aeronautics (AMA) ... Model Aviation Day will take place from 9 a.m. to 2 p.m. at the ... for all ages. , Aviation Adventure Day will be packed with entertaining activities for ...
(Date:7/17/2017)... Utah (PRWEB) , ... July 17, 2017 , ... ... molecular diagnostics company that has developed and intends both to manufacture and sell ... trading on the NASDAQ Capital Market. , Headquartered in Sandy, Utah, Co-Diagnostics’ intellectual ...
Breaking Biology Technology: