Navigation Links
Cell discovery could hold key to causes of inherited diseases
Date:2/26/2013

Fresh insights into the protective seal that surrounds the DNA of our cells could help develop treatments for inherited muscle, brain, bone and skin disorders.

Researchers have discovered that the proteins within this coating known as the nuclear envelope vary greatly between cells in different organs of the body.

This variation means that certain disease causing proteins will interact with the proteins in the protective seal to cause illness in some organs, but not others.

Until now scientists had thought that all proteins within the nuclear envelope were the same in every type of organ.

In particular the finding may provide insights into a rare muscle disease, Emery-Dreifuss muscular dystrophy.

This condition causes muscle wastage and heart problems, affects only muscles, even though it is caused by a defect in a nuclear envelope protein found in every cell in the body.

Scientists say that the envelope proteins they have identified as being specific to muscle may interact with the defective nuclear envelope protein that causes Emery-Dreifuss muscular dystrophy, to give rise to the disease.

In a similar way, this may help to explain other heritable diseases that only affect certain parts of the body despite the defective proteins being present in every cell. The study also identified nuclear envelope proteins specific to liver and blood.

Some of these also interact with proteins in all cells that are responsible for other nuclear envelope diseases, ranging from brain and fat to skin diseases, and so may help explain why things go wrong.

Dr Eric Schirmer, of the University of Edinburgh's Wellcome Trust Centre for Cell Biology, who led the study said: "Nobody could have imagined what we found.

The fact that most proteins in the nuclear envelope would be specific for certain tissue types is a very exciting development. This may finally enable us to understand this ever-growing spectrum of inherited diseases as well as new aspects of tissue-specific gene regulation."

The findings build on previous research that showed proteins in the nuclear envelope are linked to more than 20 heritable diseases.


'/>"/>
Contact: Eleanor Cowie
eleanor.cowie@ed.ac.uk
01-316-506-382
University of Edinburgh
Source:Eurekalert

Related biology news :

1. New scorpion discovery near metropolitan Tucson, Arizona
2. The discovery of a new genus of crustacean and 5 new species
3. A*STAR scientists groundbreaking discovery of nucleus structure crucial to understanding diseases
4. Discovery of sexual mating in Candida albicans could provide insights into infections
5. New discovery in autism-related disorder reveals key mechanism in brain development and disease
6. Discovery of Africa moth species important for agriculture, controlling invasive plants
7. Discovery may pave way to genetically enhanced biofuel crops
8. LSUHSC research discovery provides therapeutic target for ALS
9. Discovery of pathway leading to depression reveals new drug targets
10. Discovery of 100 million-year-old regions of DNA shows short cut to crop science advances
11. Discovery of molecular pathway of Alzheimers disease reveals new drug targets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2017)... SAN FRANCISCO , Feb. 13, 2017 /PRNewswire/ ... a centralized platform that is designed to enhance ... the latest release in the RSA Fraud & ... to enable organizations to leverage additional insights from ... anti-fraud tools to better protect their customers from ...
(Date:2/9/2017)... LONDON , Feb. 9, 2017 The ... in-depth analysis of the biomass boiler market globally in ... sales of biomass boilers. The market for biomass boilers ... product type, end-user, application, and country/region. The market based ... agriculture & forest residues, biogas & energy crops, urban ...
(Date:2/8/2017)... -- Report Highlights ... The global synthetic-biology market reached nearly $3.9 billion ... at a compound annual growth rate (CAGR) of 24.0% through ... markets for synthetic biology. - Analyses of global market trends, ... compound annual growth rates (CAGRs) through 2021. - Coverage of ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... TRIANGLE PARK, N.C., Feb. 22, 2017  United Therapeutics ... its financial results for the fourth quarter and ... 2016 financial results reflect continued growth as net ... million," said Martine Rothblatt, Ph.D., United Therapeutics, Chairman ... our ability to develop and advance our growing ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... to build connected digital health applications, announced a partnership with Redox, a leader ... seamlessly connect to many clinical systems while keeping data secure in the cloud. ...
(Date:2/21/2017)... ... February 21, 2017 , ... Cancer diagnostics ... has joined its executive team to lead the development and commercialization of its ... help improve the diagnosis and treatment of cancer. The CIDT addresses the need ...
(Date:2/21/2017)... CA (PRWEB) , ... February 21, 2017 , ... ... its GMP cell therapy manufacturing facility at its headquarters laboratory in Poway, California. ... and utilizing the experience of both in-house personnel and consultants, VetStem constructed and ...
Breaking Biology Technology: