Navigation Links
Cell discovery could hold key to causes of inherited diseases
Date:2/26/2013

Fresh insights into the protective seal that surrounds the DNA of our cells could help develop treatments for inherited muscle, brain, bone and skin disorders.

Researchers have discovered that the proteins within this coating known as the nuclear envelope vary greatly between cells in different organs of the body.

This variation means that certain disease causing proteins will interact with the proteins in the protective seal to cause illness in some organs, but not others.

Until now scientists had thought that all proteins within the nuclear envelope were the same in every type of organ.

In particular the finding may provide insights into a rare muscle disease, Emery-Dreifuss muscular dystrophy.

This condition causes muscle wastage and heart problems, affects only muscles, even though it is caused by a defect in a nuclear envelope protein found in every cell in the body.

Scientists say that the envelope proteins they have identified as being specific to muscle may interact with the defective nuclear envelope protein that causes Emery-Dreifuss muscular dystrophy, to give rise to the disease.

In a similar way, this may help to explain other heritable diseases that only affect certain parts of the body despite the defective proteins being present in every cell. The study also identified nuclear envelope proteins specific to liver and blood.

Some of these also interact with proteins in all cells that are responsible for other nuclear envelope diseases, ranging from brain and fat to skin diseases, and so may help explain why things go wrong.

Dr Eric Schirmer, of the University of Edinburgh's Wellcome Trust Centre for Cell Biology, who led the study said: "Nobody could have imagined what we found.

The fact that most proteins in the nuclear envelope would be specific for certain tissue types is a very exciting development. This may finally enable us to understand this ever-growing spectrum of inherited diseases as well as new aspects of tissue-specific gene regulation."

The findings build on previous research that showed proteins in the nuclear envelope are linked to more than 20 heritable diseases.


'/>"/>
Contact: Eleanor Cowie
eleanor.cowie@ed.ac.uk
01-316-506-382
University of Edinburgh
Source:Eurekalert

Related biology news :

1. New scorpion discovery near metropolitan Tucson, Arizona
2. The discovery of a new genus of crustacean and 5 new species
3. A*STAR scientists groundbreaking discovery of nucleus structure crucial to understanding diseases
4. Discovery of sexual mating in Candida albicans could provide insights into infections
5. New discovery in autism-related disorder reveals key mechanism in brain development and disease
6. Discovery of Africa moth species important for agriculture, controlling invasive plants
7. Discovery may pave way to genetically enhanced biofuel crops
8. LSUHSC research discovery provides therapeutic target for ALS
9. Discovery of pathway leading to depression reveals new drug targets
10. Discovery of 100 million-year-old regions of DNA shows short cut to crop science advances
11. Discovery of molecular pathway of Alzheimers disease reveals new drug targets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert in ... media edge server, the M820, which features the company,s hybrid codec ... provided by Tera Probe, Inc., will be showcased during the upcoming ... NAB show at the Las Vegas Convention ... Click ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
(Date:4/6/2017)... , April 6, 2017 Forecasts ... ANPR, Document Readers, by End-Use (Transportation & Logistics, Government ... Oil, Gas & Fossil Generation Facility, Nuclear Power), Industrial, ... Other) Are you looking for a definitive ... ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... July 17, 2017 , ... ... long-standing innovation strategy. A website (openinnovation.pioneer.com) dedicated to connecting third-party innovators ... – trait discovery, plant breeding, enabling technologies, biologicals and digital solutions. , “DuPont ...
(Date:7/14/2017)... (PRWEB) , ... July 14, 2017 , ... ... conscious EMS company . Sonic Manufacturing Technologies has installed a solar system on ... in a three-year period,” the President of Sonic, Kenneth Raab stated. The company’s ...
(Date:7/13/2017)... ... 2017 , ... Thousands of pilots from across the country will visit the ... Pilots come to Muncie to compete in various categories of model flying competition. Each ... in world championships. , RC Pylon (July 14-21): One of the most fun competitions ...
(Date:7/13/2017)... ... July 13, 2017 , ... Frederick’s first and ... robust growth in the past year after an intensive restructuring. Under the leadership ... Programs and expanded its board of directors to revitalize the organization. As a ...
Breaking Biology Technology: