Navigation Links
Cell death pathway linked to mitochondrial fusion
Date:1/24/2011

ifferent from the type that leads to cell death, Nunnari said. Bax leads to cell death when it inserts itself in the mitochondrial membrane. In its soluble, free-floating form, it causes mitochondria to fuse instead.

MFN1 and MFN2 are found in different amounts in different body organs. MFN2 is more abundant in the brain and heart -- tissues where cell death can have disastrous consequences.

The paper shows how MFN2 could act to protect the brain or heart from cell death, by using Bax in a different form, Nunnari said.

"This shows that the fusion machine is both positively and negatively regulated in cells and opens doors to finding the regulatory mechanisms and discovering ways to increase or decrease the sensitivity of cells to apoptosis," Hoppins said. That could lead to new drugs that save cells, for heart disease and stroke, or that kill cells, for cancer.


'/>"/>

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis
Source:Eurekalert

Page: 1 2

Related biology news :

1. Breast cancer cells recycle to escape death by hormonal therapy
2. Genes that control cell death fingered in age-related hearing loss
3. Caltech geobiologists discover unique magnetic death star fossil
4. Forced evolution: Can we mutate viruses to death?
5. Drops in blood oxygen levels may be key to sudden death in some epilepsy patients
6. New technology aims to reduce maternal and neonatal deaths
7. Fewer deaths with preventive antibiotic use
8. Burnham researchers discover on switch for cell death signaling mechanism
9. Study helps explain connection between sleep apnea, stroke and death
10. Stroke Belt deaths tied to non-traditional risk factors
11. Jefferson scientists discover a key protein regulator of inflammation and cell death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/24/2015)... Calif. , Aug. 24, 2015  Based on its ... recognizes DERMALOG with the 2015 African Biometrics Company of the ... has achieved substantial commercial success in Africa ... , where it has implemented one of the largest ... banks as well as the Central Bank of ...
(Date:8/19/2015)... , Aug. 19, 2015  VOXX International ... it has entered into a Definitive Agreement to ... of iris authentication market leader EyeLock through an ... will have a controlling interest in the acquiring ... to completion of due diligence.  Expanding on its ...
(Date:8/12/2015)... 2015   MedNet Solutions , an innovative SaaS-based ... clinical research, is proud to announce that ... eClinical technology platform, has led the way to significant ... of 2015.   Q2 2015 and Q1 2015 were, ... contract value sold in the company,s 15 year history.  ...
Breaking Biology News(10 mins):Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 6VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5MedNet Solutions Experiences Explosive Corporate Growth 2
... LOUIS - Researchers at the Saint Louis University School ... causes Parkinsons disease a breakthrough finding that could ... to treat one of the most common and debilitating ... Parkinsons disease, which afflicts more than 1.5 million Americans, ...
... Institute will host its third annual Ocean Future Symposium, ... 12 p.m., in the Woodrow Wilson auditorium. The symposium, ... Communities for Action," will envision a future where media ... to increase the general publics coastal and ocean literacy. ...
... of amphibians have been discovered in 330 million-year-old rocks ... and bodies of three previously unknown, foot-long salamander-like critters ... "Body impressions like this are wholly ... the New Mexico Museum of Natural History and Science. ...
Cached Biology News:St. Louis University scientists identify chemical that triggers Parkinson's disease 2Abel to receive posthumous Ocean and Coastal Leadership award 2Ancient amphibians left full-body imprints 2
(Date:8/28/2015)... Texas (PRWEB) , ... August 28, 2015 , ... ... Riordan, PhD and orthopedic surgeon, Wade McKenna, DO, announced today that the use ... Dallas, Texas, resulted in complete healing of an otherwise non-healing surgical knee wound. ...
(Date:8/27/2015)... /PRNewswire/ - Portage Biotech Inc. ("Portage") (OTC Market: ... Holding Company Limited (Biohaven), announced today that dosing ... BHV-0223, a glutamate modulating agent. Biohaven filed an ... obtained clearance from the U.S. Food and Drug ... holds 54% equity interest in Biohaven, a private ...
(Date:8/27/2015)... NEW YORK , August 27, 2015 ... on enhancing image processing functions in the human vision system, ... Angeles point guard Chris Paul to ... basketball players who want to improve their real-life on-court performance. ... on the court, whether it is shooting a ball or ...
(Date:8/26/2015)... KS (PRWEB) , ... August 26, 2015 , ... ... Biologic Solutions, announces today that a second US laboratory is to open in ... accordance with the continued partnership and long-term growth of research and development through ...
Breaking Biology Technology:Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 2Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 3Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue To Successfully Treat Non-Healing Surgical Wound 4Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 3MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3
... June 18 GeoVax Labs, Inc. (OTC ... vaccines for diseases caused by the HIV-1 (Human Immunodeficiency ... signed a proposal to discuss a cooperative arrangement with ... Commissioner,s of Cook County; the Cook County Health and ...
... NEW YORK, June 18 In designing and conducting ... while preventing program "drift," according to Matthew Lehman, chief ... remarks at a recent seminar for biotechnology companies. ... for Success: Balancing FDA Expectations and Operational Reality," at ...
... June 18 2009 is the year of the 40th,anniversary ... - the ICP 11. , Today, ... Vineyard Castle Wackerbarth near Dresden. For the festive,ceremony, CEO Roland ... , In 1968, the fluorescence based ...
Cached Biology Technology:GeoVax Signs HIV/AIDS Vaccine Proposal With Health and Hospital System of Cook County, Illinois 2GeoVax Signs HIV/AIDS Vaccine Proposal With Health and Hospital System of Cook County, Illinois 3GeoVax Signs HIV/AIDS Vaccine Proposal With Health and Hospital System of Cook County, Illinois 4GeoVax Signs HIV/AIDS Vaccine Proposal With Health and Hospital System of Cook County, Illinois 5Matthew Lehman of SPRI Clinical Trials Speaks On Designing Trials For Success At The Trout Group Investor Relations Seminar 2A Worldwide Milestone in Cell Analysis - 40 Years of Flow Cytometry 2