Navigation Links
Cell biology -- new insights into the life of microtubules
Date:7/2/2012

Every second, around 25 million cell divisions take place in our bodies. This process is driven by microtubule filaments which continually grow and shrink. A new study shows how so-called motor proteins in the cytosol can control their dynamics.

The cytoskeleton plays a central role in the process of cell division. It is composed in large part of protein filaments known as microtubules, which also help determine the size, shape and mobility of a cell. In a new study, LMU biophysicist Erwin Frey and his colleagues Anna Melbinger and Louis Reese have used a theoretical model to show how cells control the construction and breakdown of microtubules. The dy-namics of this process affect how cells divide, and how they maintain the cytoskeleton. In particular, it is responsible for regulating the size and shape of the mitotic spindle.

Easy come, easy go

Theoretical modeling has now revealed that the regulation of microtubule length relies on the length of the filament itself: The longer the filament the more motor proteins can attach to it. These all move towards the 'plus end' of the microtubule and tend to pile up as they do so. Upon arrival at the plus-end they shorten the filament. In parallel, new microtubule building blocks bind to precisely the same 'plus end' through spontaneous polymerization from the surrounding cytosol, and the filament grows.

It has now been demonstrated that such interplay between growth and length-dependent shrinkage indeed results in the maintenance of a precisely regulated microtubule length. This kind of length regulation might be essential for many intracellular tasks which depend on microtubules of a certain length. (Physical Review Letters, 22. June 2012)


'/>"/>

Contact: Dr. Kathrin Bilgeri
kathrin.bilgeri@lmu.de
49-892-180-6938
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1

Related biology news :

1. 3-V Biosciences Appoints Douglas I. Buckley, PhD, as Vice President of Biology
2. Oligonucleotide Delivery: Biology, Engineering and Development Conference
3. GW announces creation of Computational Biology Institute to conduct integrated research
4. MARC travel award announced for the 2012 GSA Yeast Genetics and Molecular Biology Meeting
5. Infection biology: The elusive third factor
6. Tips from the Journals of the American Society for Microbiology
7. MARC travel awards announced for the Society for Developmental Biology 71st Annual Meeting
8. The American Society for Microbiology honors Anthony R. Richardson
9. The American Society for Microbiology honors Susan Sharp
10. The American Society for Microbiology honors Geoffrey L. Smith
11. The American Society for Microbiology honors I. Kaye Wachsmuth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2015)... , February 11, 2015 ... research report "Access Control Market by Product (Cards and ... Residential, Military and Defense, Government, Industrial, Healthcare, Education) and ... published by MarketsandMarkets, the Access Control Market ... 2020, growing at a CAGR of 10.6% ...
(Date:2/9/2015)... -- Lintec of America recently announced an exclusive license to ... including sheets, yarns and ribbons, developed at the University ... vast industrial resources of the global Lintec Group, headquartered ... America is forming the Nano-Science and Technology Center (NSTC) ... scaling up the manufacturing and commercialization of nano engineered ...
(Date:2/5/2015)... 2015  Marken is starting its 35 th ... a new marketing campaign to solidify its place as ... campaign focuses on First as a primary ... The first headline in the series, ... its client,s priorities. Marken recognizes the need to protect ...
Breaking Biology News(10 mins):Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4Marken Launches New Patient-Centric Campaign 2
... study by the University of Santiago de Compostela on Kentish ... in hydrocarbon levels along the coast of Galicia five years ... works to remove the wreck, pollution levels began to rise ... fires., On 19th November 2002 the oil tanker Prestige sank ...
... become a science in the past 25 years, but ... widespread international collaboration, broad disciplinary composition and wide geographic ... Laboratory and Indiana University. The findings, published today in ... were assembled from a review of 20,000 academic ...
... University in St. Louis paleoanthropologist Glenn Conroy, PhD, discovered the ... known pre-human ape ever found south of the equator in ... in Namibia. Traditionally, fossil-hunters often could only make educated ... chance finding the proverbial needle in a haystack. ...
Cached Biology News:Hydrocarbon pollution along the coast of Galicia shot up five years after the Prestige oil spill 2After 25 years, sustainability is a growing science that's here to stay 2Human, artificial intelligence join forces to pinpoint fossil locations 2
(Date:3/6/2015)... 2015 BioSpecifics Technologies Corp. (NASDAQ: ... collagenase-based products marketed as XIAFLEX ® (collagenase clostridium ...  in the EU, announced today that it will host ... a.m. ET on Friday, March 13, 2015 to report ... and provide a corporate update. In ...
(Date:3/6/2015)... (PRWEB) March 06, 2015 Transparency Market Research ... and Other Crops - Global Industry Analysis, Size, Share, Growth, ... the global isoxaflutole market was valued at US$ 116.3 Mn ... by 2020, expanding at a CAGR of 5.1% from 2014 ... isoxaflutole stood at 2,569.5 kilo tons in 2013. , Isoxaflutole ...
(Date:3/6/2015)... Wash. , March 6, 2015   BioLife ... leading developer, manufacturer and marketer of proprietary clinical grade ... media and precision thermal shipping products for ... the Company,s fourth quarter and full year 2014 financial results ... that the Company will host a conference call and ...
(Date:3/5/2015)... March 5, 2015  DuPont (NYSE: DD ... and Industrials Conference held today in New ... L. Trerotola discussed strategy, progress and plans to ... DuPont.  Strengthening and growing the company,s leading position in ... of strategic priority for DuPont. Discussing the ...
Breaking Biology Technology:BioSpecifics Technologies Corp. to Host Conference Call to Report Fourth Quarter and Full Year 2014 Financial Results on Friday, March 13, 2015 2Isoxaflutole Market is Expected to Reach US$ 163.0 Mn by 2020 : Transparency Market Research 2Isoxaflutole Market is Expected to Reach US$ 163.0 Mn by 2020 : Transparency Market Research 3BioLife Solutions to Report Fourth Quarter and Full Year 2014 Financial Results and Provide Business Update on March 12, 2015 2DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 2DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 3DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 4
... and SAN DIEGO, Dec. 21, 2010 Novogen Limited ... an oncology company focused on the clinical development of ... have entered into a definitive asset purchase agreement pursuant ... property portfolio in exchange for $4 million of convertible ...
... 2010 El Camino Hospital today announced its first ... El Camino Hospital is one of the first of ... trial, which is evaluating a revolutionary non-surgical, less-invasive procedure ... with severe aortic stenosis. "The Heart and ...
... Reportlinker.com announces that a new market research ... Nanobiotechnologies- applications, markets and companies ... is the creation and utilization of materials, devices, ... the nanometer-length scale (a nanometer is one billionth ...
Cached Biology Technology:Novogen and Marshall Edwards Sign Asset Purchase Agreement 2Novogen and Marshall Edwards Sign Asset Purchase Agreement 3Novogen and Marshall Edwards Sign Asset Purchase Agreement 4Novogen and Marshall Edwards Sign Asset Purchase Agreement 5El Camino Hospital Announces First Implant in Clinical Trial to Evaluate Revolutionary Heart Valve Procedure 2El Camino Hospital Announces First Implant in Clinical Trial to Evaluate Revolutionary Heart Valve Procedure 3Reportlinker Adds Nanobiotechnologies- applications, markets and companies 2Reportlinker Adds Nanobiotechnologies- applications, markets and companies 3Reportlinker Adds Nanobiotechnologies- applications, markets and companies 4Reportlinker Adds Nanobiotechnologies- applications, markets and companies 5Reportlinker Adds Nanobiotechnologies- applications, markets and companies 6Reportlinker Adds Nanobiotechnologies- applications, markets and companies 7Reportlinker Adds Nanobiotechnologies- applications, markets and companies 8Reportlinker Adds Nanobiotechnologies- applications, markets and companies 9Reportlinker Adds Nanobiotechnologies- applications, markets and companies 10Reportlinker Adds Nanobiotechnologies- applications, markets and companies 11Reportlinker Adds Nanobiotechnologies- applications, markets and companies 12Reportlinker Adds Nanobiotechnologies- applications, markets and companies 13Reportlinker Adds Nanobiotechnologies- applications, markets and companies 14Reportlinker Adds Nanobiotechnologies- applications, markets and companies 15Reportlinker Adds Nanobiotechnologies- applications, markets and companies 16Reportlinker Adds Nanobiotechnologies- applications, markets and companies 17Reportlinker Adds Nanobiotechnologies- applications, markets and companies 18Reportlinker Adds Nanobiotechnologies- applications, markets and companies 19Reportlinker Adds Nanobiotechnologies- applications, markets and companies 20Reportlinker Adds Nanobiotechnologies- applications, markets and companies 21
... 20-NW cuff pump is a dedicated cuff pump ... cuff pump replaces manual inflation and can be ... systems for mouse and rat; from single up ... 20-NW cuff pump has adjustable cut-off pressure in ...
... These handy dispensers save space and ... and other garb. They are the ... parts used in labs, processing and ... charges and the particles they attract. ...
... The thermostable dUTPase(pyrococcus fruriosus) maximizes the ... DNA polymerases). It removes contaminating ... dNTP solutions. The presence of ... reaction can prevent dUTP misincorporation by ...
... AVOID FREEZE/THAW CYCLES. An assay kit designed ... Western blotting. PARP is an enzyme implicated ... apoptosis, PARP is cleaved by caspase-3. Cleavage ... to 85 kDa is a hallmark of ...
Biology Products: