Navigation Links
Cell binding discovery brings hope to those with skin and heart problems
Date:1/20/2011

A University of Manchester scientist has revealed the mechanism that binds skin cells tightly together, which he believes will lead to new treatments for painful and debilitating skin diseases and also lethal heart defects.

Professor David Garrod, in the Faculty of Life Sciences, has found that the glue molecules bind only to similar glue molecules on other cells, making a very tough, resilient structure. Further investigation on why the molecules bind so specifically could lead to the development of clinical applications.

Professor Garrod, whose Medical Research Council-funded work is paper of the week in the Journal of Biological Chemistry (JBC) tomorrow (Friday), said: "Our skin is made up of three different layers, the outermost of which is the epidermis. This layer is only about 1/10th of a millimetre thick yet it is tough enough to protect us from the outside environment and withstand the wear and tear of everyday life.

"One reason our epidermis can do this is because its cells are very strongly bound together by tiny structures called desmosomes, sometimes likened to rivets. We know that people who have defects in their desmosomes have problems with their epidermis and get extremely unpleasant skin diseases. Understanding how desmosomes function is essential for developing better treatments for these and other types of skin disease and for non-healing wounds.

"Desmosomes are also extremely important in locking together the muscle cells of the heart, and hearts where desmosomes are defective can fail catastrophically, causing sudden death in young people.

Hence our findings may also be relevant in the heart and in developing new treatments for heart disease."

ProfessorGarrod and his team, Zhuxiang Nie, Anita Merritt, Mansour Rouhi and Lydia Tabernero, used chemical cross-linking to study cells of the epidermis and found what they believe to be the principal mechanism by which the glue molecul
'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

Page: 1 2

Related biology news :

1. Single-stranded DNA-binding protein is dynamic, critical to DNA repair
2. Novel antitoxin strategy developed using tagged binding agents
3. Direct observation of carbon monoxide binding to metal-porphyrines
4. Chemical equator discovery will aid pollution mapping
5. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
6. Groundbreaking discovery may lead to stronger antibiotics
7. Discovery of natural compounds that could slow blood vessel growth
8. Nanoscopic screening process to speed drug discovery
9. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
10. New $11 million center to speed production of new compounds for drug discovery
11. Discovery of giant roaming deep sea protist provides new perspective on animal evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... has successfully replicated one of the crucial steps in ... sunlight which could manufacture hydrogen as a fuel. , ... an exciting prospect to use them to create hydrogen, ... Hingorani, from the ARC Centre of Excellence for Translational ... Hydrogen offers potential as a zero-carbon replacement for petroleum ...
(Date:8/21/2014)... itself resulting in severe abdominal pain, vomiting and systemic ... are diagnosed with the disease resulting in 1000 deaths. ... to intravenous fluid and nutritional support. , Dr ... led the research, said "The major causes of pancreatitis ... alcohol intake combined with a high fat diet. In ...
(Date:8/20/2014)... a study of 158 pregnant teenagers in Rochester, NY, ... intentional consumption of ice, cornstarch, vacuum dust, baby powder ... Cornell study. , Moreover, such teens had significantly lower ... eat nonfood substances. , Pregnant teens, regardless of pica, ... lead to iron deficiency and anemia. Low iron in ...
Breaking Biology News(10 mins):Water and sunlight the formula for sustainable fuel 2Insulin offers new hope for the treatment of acute pancreatitis 2Pica in pregnant teens linked to low iron 2
... the behaviors of individual cells and the functions and ... the complex interactions of cell clusters have not been ... Emergent Behaviors of Integrated Cellular Systems (EBICS) Center to ... the University of Illinois at Urbana-Champaign, and the Georgia ...
... From how massive humpbacks glide through the sea with ease ... Harvard have excavated the equations behind a variety of complex ... Michael Brenner, working closely with a team of Harvard evolutionary ... most famous icon of evolution: the beaks of Darwin,s finches. ...
... industrialized countries have easy access to healthy food and nutritional ... because new research from Tel Aviv University suggests that magnesium, ... even more critical than previously thought for the neurons of ... MIT, the research started as a part of a post-doctoral ...
Cached Biology News:$25M NSF center established to investigate the creation of biological machines 2$25M NSF center established to investigate the creation of biological machines 3$25M NSF center established to investigate the creation of biological machines 4Simple math explains dramatic beak shape variation in Darwin's finches 2Simple math explains dramatic beak shape variation in Darwin's finches 3Remember magnesium if you want to remember 2
(Date:8/21/2014)... international research team including DESY scientists has observed tiny ... team reports in the journal Science that ... inside the nanodroplets. It is the first time that ... larger samples of what is known as superfluid helium, ... our best expectations," says Andrey Vilesov of the University ...
(Date:8/21/2014)... COLD SPRING, N.Y. , Aug. 21, 2014 ... today the launch of their Nutraceutical "TELO-20 for ... first and only Telomere-lengthening supplement in the world ... the ends of every chromosome in the body. ... the world,s leading experts in Telomere Science and ...
(Date:8/21/2014)... 2014 OTC Markets Group Inc. ... biotechnology company, on its approval to list on ... OTCQX®, the best marketplace for established U.S. and ... Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO ... of its growth strategy and achievement of this ...
(Date:8/21/2014)... Bulgaria (PRWEB) August 21, 2014 ... released today by Ontotext . Now the ... semantic analysis of structured and unstructured data is available ... the cost of enterprise technology. Organizations that do not ... for data management can use S4 since there is ...
Breaking Biology Technology:Scientists observe quantum vortices in cold helium droplets 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4
... , BETHESDA, Md., Sept. 21 ... company developing novel, proprietary antibodies for the treatment of cancer, ... a phase 1 dose-escalation clinical study for BiTE antibody MT110, ... tumors. The interim data(1) were presented at the Multidisciplinary ...
... , , , ... 21 Volcano Corporation (Nasdaq: VOLC ), a leader ... and treatment of coronary and peripheral artery disease, announced today its ... Francisco, CA from September 21-25. Volcano programming for TCT includes a ...
... ST. PAUL, Minn., Sept. 21 Brennen Medical, LLC, ... device to Davol Inc., a subsidiary of C.R. Bard, Inc. ... of the hernia products business of Brennen Medical, LLC. This ... in soft tissue repair including hernia and abdominal wall reconstruction. , ...
Cached Biology Technology:Micromet Reports Interim Data from Phase 1 Study of BiTE Antibody MT110 for the Treatment of Solid Tumors 2Micromet Reports Interim Data from Phase 1 Study of BiTE Antibody MT110 for the Treatment of Solid Tumors 3Micromet Reports Interim Data from Phase 1 Study of BiTE Antibody MT110 for the Treatment of Solid Tumors 4Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 2Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 3Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 4Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 5Volcano Corporation Announces Schedule of Events for the 2009 Transcatheter Cardiovascular Therapeutics (TCT) Conference 6Brennen Medical Announces Sale of XenMatrix(R) 2
Mouse Activin RIB/ALK-4 MAb (Clone 207304)...
Normal human serum, single donor...
... SYBR Green, TaqMan, LNA spiked TaqMan, MethyLight, ... specific primers are designed by avoiding cross ... results. Primer efficiency is enhanced by avoiding ... the Mfold server. Beacon Designer can be ...
Agar, 5 lb. Bacteriological.Moisture: < 10%, ash: < 6.5%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Biology Products: