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Cell 'anchors' required to prevent muscular dystrophy
Date:1/13/2009

mice to learn how the muscle cells fared without ankG. The cells tore apart.

The researchers also discovered that ankB stabilized a set of structures found in all cells, called microtubules. These structures are like tracks for the molecular motors that carry the dystrophin molecules from the site where they are made to their specific destination. Ankyrin B helps microtubules align so dystrophin molecules can travel to the membrane and then ankyrin G holds them in place, Bennett explained.

"I'm excited because ankyrin-B's ability to anchor microtubules could have broad implications in many cell types," Bennett said.


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Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

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