Navigation Links
Cell Transplantation study investigates fate and function of cells transplanted to the CNS
Date:12/20/2012

Putnam Valley, NY. (Dec. 20, 2012) When different types of cells are transplanted with the intent of having them aid in repairing central nervous system (CNS) trauma, what is the fate and function of those cells? A Belgian research team carried out research aimed at answering this question by determining how five varieties of cells - neural stem cells, mouse embryonic fibroblasts, dendritic cells, bone marrow mononuclear cells (BMMNCs) and splenocytes - functioned and survived after transplantation in the CNS.

Their study is published in a recent issue of Cell Transplantation (21:9), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

"Severe injuries to the central nervous system due to trauma are among the top five causes of death and represent a significant social and economic health burden on society," said Dr. Peter Ponsaerts of the University of Antwerp. "There are no currently effective treatments to restore damaged or dysfunctional neural tissues, although much progress is expected to come from stem cell research."

Their research investigated how factors such as cell migration, cell graft survival, cell graft immunogenicity and cell graft toxicity are impacted two weeks post-transplantation. Their study examined the fate and function of the five varieties of cells mentioned above after they were transplanted into the CNS of transgenic mice, both healthy and those modeled with CNS injury with subsequent inflammation.

"We did not see a significant increase for any cell types in cell migration under inflammatory conditions when compared to healthy conditions," said the authors. "With regard to cell graft survival, to our surprise, only a few of the cells were able to survive under both healthy and inflammatory conditions."

However, they found "striking differences" in how endogenous immune responses against grafted cells were organized. They speculated that differences were due to both the degree of microglia and astrocyte invasion. Responses of both were observed in each different cell variety. BMMNC and splenocyte grafts were less invaded by microglia, but displayed high levels of astrocyte invasion.

Finally, with regard to cell graft toxicity, the researchers found that "none of the cell populations could directly contribute to remyelination." They speculated that two weeks might not be sufficient time for proper differentiation of grafted NSCs, although endogenous remyelination does occur within a two-week time period.

"Our results warrant further research to better understand and eventually control cell graft induced tissue damage and activation of the brain's innate immune system," they wrote.


'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Cell Transplantation reports islet cell advancement increases impact on transplantation
2. Neurons made from stem cells drive brain activity after transplantation in laboratory model
3. Studies in Cell Transplantation investigate oxygens impact as a factor in transplantation
4. New studies show spinal cord injury and ALS respond to cell transplantation
5. Stem cell transplantation into mouse cochlea may impact future hearing loss therapies
6. Some factors that impact islet transplantation explored in Cell Transplantation papers
7. Some factors that impact islet transplantation explored in Cell Transplantation papers
8. 2 Cell Transplantation studies impact dental stem cell research for therapeutic purposes
9. Gut microbiota transplantation may prevent development of diabetes and fatty liver disease
10. Study reports iron oxide nanoparticles effective for labeling human endothelial cells
11. Study looks at gray seal impact on beach water quality
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... December 1, 2016 The ... Voice), Future Technology (Iris Recognition System), Vehicle Type ... Global Forecast to 2021", published by MarketsandMarkets, the ... in 2016, and is projected to grow to ... of 14.06%.      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:11/30/2016)... CHICAGO , Nov. 30, 2016  higi ... a new partnership initiative targeting national brands, industry ... and reward their respective audiences for taking steps ... Since its inception in 2012, higi has built ... US, impacting over 38 million people who have ...
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s high-speed AFIS    ... ... DERMALOG is Germany's largest Multi-Biometric supplier: The company's Fingerprint ... ... Multi-Biometric supplier: The company's Fingerprint Identification System is part of an efficient ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... ... December 08, 2016 , ... Opal ... provide essential device-to-computer interconnect using USB or PCI Express, announced the FOMD-ACV-A4, the ... FOMD-ACV-A4 is a small, thin, SODIMM-style module that fits a standard 204-pin SODIMM ...
(Date:12/8/2016)... 2016  Anaconda BioMed S.L., a pre-clinical stage medical ... generation neuro-thrombectomy system for the treatment of Acute Ischemic ... MD to join its Scientific Advisory Board (SAB). The ... of scientific and clinical experts to Anaconda BioMed S.L., ... BRAIN ® to its clinical phase. The SAB ...
(Date:12/8/2016)... ... December 08, 2016 , ... Microbial genomics leader, uBiome, joins ... one of just six company finalists in the Health & Medicine category. Over ... nominated as finalists in this year’s awards include Google, SpaceX, Oculus, and SolarCity. ...
(Date:12/8/2016)... , Dec. 8, 2016 Soligenix, Inc. (OTCQB: ... focused on developing and commercializing products to treat rare ... today that it will be hosting an Investor Webcast ... on the origins of innate defense regulators (IDRs) as ... of oral mucositis and the recently announced and published ...
Breaking Biology Technology: