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Cell Transplantation reports islet cell advancement increases impact on transplantation
Date:11/27/2012

adequate oxygen and nutrient supplies in the core of the islets.

To help prevent cell death by improving the cell's regulation of glucose metabolism, and to help prevent programmed cell death (apoptosis), the researchers created a molecularly engineered (PEG-Sp-Ex-4) regimen to coat the ICCs. The ICCs were also accompanied by factors to counter immune rejection.

"We demonstrated that the viability of the ICCs was significantly higher than that of single, large islets when cultured for 25 days," said Dr. Lee. "When applied in human-to-human islet transplantation, the use of this strategy could contribute to higher islet cells success rates when transplanting islet cells to treat diabetes mellitus."


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Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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