Navigation Links
Cell Transplantation reports islet cell advancement increases impact on transplantation
Date:11/27/2012

Putnam Valley, NY. (Nov. 27, 2012) A study published in the current issue of Cell Transplantation (21:8), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/ , reports that a team of researchers in South Korea have successfully engineered islet cell clusters (ICCs) that will improve pancreatic islet transplantation and offer promise for curing diabetes mellitus.

Carried out by collaborating researchers at three universities in Seoul, Korea, the new process of creating ICCs included delivering a gene to single islet cells that increased their glucose sensitivity; reducing the size of cells in the cluster and; modifying the ICCs' surface with a poly-lipid to help prevent immune reactions. According to the researchers, their work is potentially far-reaching by helping to overcome the shortage of islet cells with respect to transplantation and reducing the need for immunosuppressant regimes, an important factor in eliminating the possible adverse impact of transplantation.

"Transplantation of isolated pancreatic islets has shown tremendous potential for curing patients with type I diabetes," said study co-author Dong Yun Lee of Hanyang University's Department of Bioengineering. "But transplanted islet cells face challenges, such as hypoxic (low oxygen) conditions and the host's aggressive immune reactions. Accordingly, we developed a clinically adaptable way to create islet cell clusters engineered to overcome these challenges."

They noted that encapsulated islets incurred cell death due to hypoxia caused by the relatively large size of the capsule and the impurity of the biomaterials from which they were made. Hypoxia has also caused the early loss of graft function. The research team hypothesized that when islets of smaller size were grouped into clusters, they would be less susceptible to immune reaction, ischemia and starvation because of adequate oxygen and nutrient supplies in the core of the islets.

To help prevent cell death by improving the cell's regulation of glucose metabolism, and to help prevent programmed cell death (apoptosis), the researchers created a molecularly engineered (PEG-Sp-Ex-4) regimen to coat the ICCs. The ICCs were also accompanied by factors to counter immune rejection.

"We demonstrated that the viability of the ICCs was significantly higher than that of single, large islets when cultured for 25 days," said Dr. Lee. "When applied in human-to-human islet transplantation, the use of this strategy could contribute to higher islet cells success rates when transplanting islet cells to treat diabetes mellitus."


'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Neurons made from stem cells drive brain activity after transplantation in laboratory model
2. Studies in Cell Transplantation investigate oxygens impact as a factor in transplantation
3. New studies show spinal cord injury and ALS respond to cell transplantation
4. Stem cell transplantation into mouse cochlea may impact future hearing loss therapies
5. Some factors that impact islet transplantation explored in Cell Transplantation papers
6. Some factors that impact islet transplantation explored in Cell Transplantation papers
7. 2 Cell Transplantation studies impact dental stem cell research for therapeutic purposes
8. Gut microbiota transplantation may prevent development of diabetes and fatty liver disease
9. New low carbon TINA reports
10. Texas Biomed reports faster, more economical method for detecting bioterror threats
11. Aware, Inc. Reports Third Quarter 2012 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... , June 22, 2016 On Monday, the ... to industry to share solutions for the Biometric Exit ... Customs and Border Protection (CBP), explains that CBP intends ... departing the United States , in ... to defeat imposters. Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/9/2016)...  Perkotek an innovation leader in attendance control systems is proud to announce the ... employers to make sure the right employees are actually signing in, and to even ... ... ... ...
(Date:6/2/2016)... NEW YORK , June 2, 2016   The ... (Weather), is announcing Watson Ads, an industry-first capability in which ... advertising, by being able to ask questions via voice or ... Marketers have long ... with the consumer, that can be personal, relevant and valuable; ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... ... Supplyframe, the Industry Network for electronics hardware design and ... in Pasadena, Calif., the Design Lab’s mission is to bring together inventors and ... brought to market. , The Design Lab is Supplyframe’s physical representation of one ...
(Date:6/23/2016)... Apellis Pharmaceuticals, Inc. today announced positive ... its complement C3 inhibitor, APL-2. The trials were ... studies designed to assess the safety, tolerability, pharmacokinetics ... healthy adult volunteers. Forty subjects were ... dose (ranging from 45 to 1,440mg) or repeated ...
(Date:6/23/2016)... -- On Wednesday, June 22, 2016, the NASDAQ ... Dow Jones Industrial Average edged 0.27% lower to finish at ... Stock-Callers.com has initiated coverage on the following equities: Infinity Pharmaceuticals ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ... Learn more about these stocks by accessing their free trade ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... new line of intelligent tools designed, tuned and optimized exclusively for Okuma CNC ... in Chicago. The result of a collaboration among several companies with expertise in ...
Breaking Biology Technology: