Navigation Links
Cell Transplantation reports consistent and successful islet isolations offer diabetes hope
Date:6/3/2010

Tampa, Fla. (June 3, 2010) A team of researchers from several collaborating Baylor University research centers and from Japan's Okayama Graduate School of Medicine have found a way to more consistently isolate pancreatic islet cells from brain dead donors using ductal injection (DI), a process that immediately cools donor islet cells at the injection site. The more successful islet isolation process resulted in the three type 1-diabetes patients, who received islet cell transplants, becoming insulin independent.

Their study is published in issue 19(3) of Cell Transplantation and it is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/ .

"Inconsistent islet isolation is one of the important issues in clinical islet transplantation," said Dr. Shinichi Matsumoto, the research team's lead author. "Failure of donor islet isolation often results from the loss of the donor pancreas. Our simple modification of the retrieval process appears valuable for assuring greater success in islet transplantation."

Ductal injection is a procedure that modifies the islet isolation process using a cooling solution on the pancreatic islet cells derived from brain-dead donors. The cooling solution, applied at the donor's pancreatic ductal site, aids the viability of the islet cells.

The team successfully isolated islet cells in the DI group seven times while only three out of eight islet cell groups were isolated in the nonductal injection group. When islets from the DI group were transplanted into three type 1 diabetic patients, all three became insulin independent.

"DI significantly improved the quantity and quality of isolated islets and resulted in a high success rate of clinical islet transplantation," said Dr. Matsumoto.

According to the research team, a fifty percent success rate for clinical islet isolation has been standard; they were able to achieve a better than 80 percent success rate using DI.

The team reported that there were no significant demographic or clinical differences in the two patient groups receiving islet transplants, nor were there significant differences in the donated pancreata. All donor pancreata were preserved for less than six hours. Each patient received two islet preparations.

"In the DI group, the fasting blood glucose of all three patients improved after a single islet transplantation, and improved further after the second transplantation," commented Dr. Matsumoto. "None of these patients experienced subsequent hypoglycemia, and all three became insulin independent."

The team had recently shown that the DI process was successful in animal models because DI prevented tissue and cell death, suggesting that DI improved the quality and quantity of the isolated islet cells destined for transplantation.

"The number of islets isolated from donor pancreata continues to be quite variable and many times are not sufficient for clinical transplantation" said Dr. Rodolfo Alejandro, section editor for Cell Transplantation and Professor of Medicine at the University of Miami Miller School of Medicine. "This paper describes a novel approach to improve islet isolation yields. These are promising results that need to be confirmed in a randomized concurrent protocol".


'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Novel Parkinsons treatment strategy involves cell transplantation
2. Rare genetic disease successfully reversed using stem cell transplantation
3. Ovarian transplantation: First baby is born after a new technique
4. Ovarian transplantation: New technique gives greatly improved results in this delicate operation
5. REGiMMUNE presents enhanced efficacy data in preclinical transplantation models
6. New book includes advances in the science and practice of transfusion and transplantation
7. Embryonic stem cells might help reduce transplantation rejection
8. Researchers discover link between organ transplantation and increased cancer risk
9. Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
10. Clearance of hepatitis C viral infection after liver transplantation
11. New climate change reports underscore need for action
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at VivaTech ... startups and global businesses, taking place in Paris ... will showcase the solutions they have built with IBM Watson ... France is one of the most dynamic ... in the number of startups created between 2012 and 2015*, ...
(Date:5/16/2017)... N.J. , May 16, 2017  Veratad Technologies, ... provider of online age and identity verification solutions, announced ... K(NO)W Identity Conference 2017, May 15 thru May 17, ... Regan Building and International Trade Center. ... the globe and in today,s quickly evolving digital world, ...
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... the implantation and pregnancy rates in frozen and fresh in vitro fertilization ... progesterone and maternal age to IVF success. , After comparing the results from ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO ... Diego Rotary Club. The event entitled “Stem Cells and Their Regenerative ... attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings announced ... by which its ProCell stem cell therapy prevents ... ischemia.  The Company, demonstrated that treatment with ProCell ... limbs saved as compared to standard bone marrow ... HGF resulted in reduction of therapeutic effect.  ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... and applications consulting for microscopy and surface analysis, Nanoscience Instruments is now ... Analytical offers a broad range of contract analysis services for advanced applications. ...
Breaking Biology Technology: