Navigation Links
Cell Therapeutics, Inc. Expects That the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) May Issue an Opinion on the Marketing Authorization Application ("MAA") on Pixuvri™ in Mid-February
Date:1/20/2012

SEATTLE, Jan. 20, 2012  /PRNewswire/ -- Cell Therapeutics, Inc. ("CTI") (NASDAQ and MTA: CTIC) announced today that, following discussions with the European Medicines Agency's ("EMA") Committee for Medicinal Products for Human Use ("CHMP"), the CHMP may issue an opinion on CTI's Marketing Authorization Application ("MAA") for Pixuvri in mid-February. In the interim, CTI will continue to work with the CHMP on the Summary of Product Characteristics and other labeling items for Pixuvri. CTI is seeking an authorization to market Pixuvri in the E.U. for the treatment of adult patients with multiple relapsed or refractory aggressive non-Hodgkin's B cell lymphomas ("NHL"). If approved by the EMA, Pixuvri would address an unmet medical need, as there are no approved therapies for these patients.

In the U.S., the Food and Drug Administration ("FDA") has set a Prescription Drug User Fee Act ("PDUFA") goal date of April 24, 2012 for a decision on the New Drug Application for Pixuvri in the same indication.

About Pixuvri (pixantrone)

Pixantrone is a novel aza-anthracenedione that has distinct structural and physio-chemical properties that make its anti-tumor activity unique in this class of agents. Similar to anthracyclines, pixantrone inhibits Topo-isomerase II but unlike anthracyclines -- rather than intercalation with DNA -- pixantrone alkylates DNA -- forming stable DNA adducts with particular specificity for CpG-rich, hyper-methylated sites. These structural differences resulted in significantly enhanced anti-lymphoma activity compared to doxorubicin in preclinical models. In addition, the structural motifs on anthracycline-like agents that are responsible for the generation of oxygen free radicals and the formation of toxic drug-metal complexes have also been modified in pixantrone in an effort to prevent the binding of iron and perpetuation of superoxide production -- both of which are the putative mechanism for anthracycline
'/>"/>

SOURCE Cell Therapeutics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology news :

1. UT-Battelle licenses tissue regeneration technologies to NellOne Therapeutics, Inc.
2. European mountain vegetation shows effects of warmer climate
3. DTU is participating in a European network on measurement of greenhouse gases
4. Register now for the European Congress on Osteoporosis & Osteoarthritis in Bordeaux
5. UK invests £75 million in European research infrastructure to support knowledge-based economy
6. EMBO awards Installation Grants to 7 European scientists
7. How does a plant survive with few mates or pollinators? A European herb has figured out its own way
8. New European project launched to address shortcomings in climate data
9. Misleading morphology: 3 European parasitoid wasp species are seasonal forms of just 1
10. Genomatix to partner in $41 million European epigenomics consortium
11. Pesticides pollute European waterbodies more than previously thought
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has announced ... America Perimeter Security Systems Market" report to their ... The North American perimeter security market is estimated ... to 2019. Although the U.S. market holds a larger ... is expected to grow at a higher CAGR of ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced ... (GCP) audit to confirm its adherence to current ... accomplishment enables HITLAB to conduct regulated smart device ... principles for patient safety and research quality. ... access, quality, and delivery with innovative technology," said ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has ... in the APAC Region 2015-2019"  report to their ... in this market is advances in technology. With ... upgrade biometric solutions to the latest standard that ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... The increasing acidity of the world,s oceans and ... definitive proof that the atmospheric carbon dioxide that is ... environment, says world-renowned Antarctic marine biologist Jim McClintock, Ph.D., ... Department of Biology. "The oceans are a sink ...
... , PARIS , Feb. 4 ... network for Eurofins Scientific, a global leader in bio-analysis. , ... will securely connect 16 key Eurofins laboratories and research centers ... with the company,s global customer base.  Verizon will use MPLS ...
... COLLEGE STATION A joke among two Texas ... found Viagra can aid fetal development in female sheep. ... can serve as an excellent animal model for studying ... Viagra (sildenafil citrate), which is used to treat male ...
Cached Biology News:Oceans reveal further impacts of climate change, says UAB expert 2Oceans reveal further impacts of climate change, says UAB expert 3Verizon Business to Provide Global IP for Eurofins Scientific 2Verizon Business to Provide Global IP for Eurofins Scientific 3Study shows male erectile dysfunction drug enhances fetal growth in female sheep 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... 2011 Sequenom, Inc. (NASDAQ: SQNM ), a ... the Company,s participation at the Lazard Capital Markets 8th Annual ... November 15-16, 2011. Harry F. Hixson, Jr, Ph.D., ... EVP of Research and Development, will present on Tuesday, November ...
... of active metamaterial that incorporates semiconductor devices into conventional ... gain while retaining its negative refraction property, a first ... and experimental results show that the addition of the ... also maintained the negative index of this kind of ...
... 9, 2011 A new diagnostic kit ... been launched at the Veterinary Cancer Society,s annual conference ... ) in the UK, the announcement is a significant ... major benefit being that it is able to differentiate ...
Cached Biology Technology:Sequenom Announces Participation at the Lazard Capital Markets 8th Annual Healthcare Conference 2New metamaterial allows transmission gain while retaining negative refraction property 2New Kit Takes the Uncertainty Out of Lymphoma Diagnosis 2
Rabbit polyclonal to Peptide E ( Abpromise for all tested applications)....
Mouse monoclonal [6911] to E. coli K99 pilus ( Abpromise for all tested applications)....
...
...
Biology Products: