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Cause of genetic disorder found in 'dark matter' of DNA
Date:11/10/2013

It does this by the release of the hormone insulin, which is generated and released by cells known as pancreatic beta cells. It also produces enzymes to help digest and absorb food.

Pancreatic agenesis means babies have diabetes from birth and problems with digesting food which prevents weight gain. The disease is rare, but its study also helps scientists gain a better understanding of how the pancreas works, which helps shed light on research into diabetes.

Professor Andrew Hattersley, a Wellcome Trust Senior Investigator who led the Exeter team said: "This finding gives a deeper understanding to families affected by this disorder, and it also tells us more about how the pancreas develops. In the longer term, this insight could have implications for regenerative stem cell treatments for Type 1 Diabetes."

The team found six different mutations in a newly discovered PTF1A regulatory region in eleven people affected by pancreatic agenesis from across the world.


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Contact: Louise Vennells
l.vennells@exeter.ac.uk
0044-013-927-24927
University of Exeter
Source:Eurekalert

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