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Cause for exaggerated insulin response in subset of bariatric surgery patients identified
Date:3/27/2014

Salehi and team, this is the largest group of gastric bypass patients with post-meal symptoms of low blood sugar to be reported to date; and among this group, abnormalities in insulin clearance as well as excessive insulin secretion during glucose drops (hyperinsulinemia) were identified.

"These abnormalities contributed to elevated insulin response and lower glucose levels in these individuals," says Salehi.

Moreover, Salehi says, findings from this study suggest that in addition to excessive insulin secretion, glucagon response to hypoglycemia is abnormal. Glucagon is another important hormone in glucose regulation. It is secreted from specific cells in the pancreas in response to low glucose.

This study, the authors says, offers a better understanding of mechanisms by which gastric bypass surgery alters glucose metabolism in general, and more specifically in those individuals suffering from hyperinsulinemic hypoglycemia syndrome.

At this point, Salehi adds, there is no specific therapeutic option available for patients with this condition beyond dietary modification; however, we expect that the future studies based on current findings will inform the development of medical and dietary interventions for treatment of this condition.


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Contact: Angela Koenig
angela.koenig@uc.edu
513-558-4625
University of Cincinnati Academic Health Center
Source:Eurekalert

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