Navigation Links
Casing the joint
Date:9/7/2010

St. Louis, MO Current research provides a novel model for rheumatoid arthritis research. The related report by LaBranche et al, "Characterization of the KRN cell transfer model of rheumatoid arthritis (KRN-CTM), a chronic yet synchronized version of the K/BxN mouse," appears in the September 2010 issue of The American Journal of Pathology.

Nearly 1% of the population is affected by rheumatoid arthritis, and women are affected three to five times more often then men. Although the course of disease varies greatly, daily living activities are impaired in most affected individuals and after 5 years approximately 33% of sufferers are no longer able to work.

Rheumatoid arthritis is characterized by chronic inflammation of the distal joints and is mediated in part by emigration and activation of immune cells. The restrictions of present animal models, which either mimic chronic disease or a synchronized version of early disease (but not both), have hampered scientific understanding of the specific roles immune cells and their mediators play in disease initiation and maintenance. In this regard, Dr. Paul Allen and colleagues at the Washington University in St. Louis School of Medicine, in collaboration with Dr. Timothy LaBranche and colleagues at Pfizer Global Research & Development developed and characterized a chronic yet synchronized animal model of rheumatoid arthritis (KRN-CTM). Disease in these animals developed with a uniform onset of 7 days post-initiation and was maintained chronically (through Day 42). These mice revealed a time course of rheumatoid arthritis characteristics including edema, immune cell infiltration, cartilage damage and osteoclast-mediated bone resorption.

According to Dr. LaBranche, "the main benefit of the KRN-CTM is its utility, which adds significant logistical and platform advantages to study T cell targets since the model is T cell-dependent and engages both early and late stages of innate and ad
'/>"/>

Contact: Angela Colmone, Ph.D.
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1 2

Related biology news :

1. BIO-key(R) International Showcasing Biometric Identification Technology at 2009 RSA Conference
2. Most panda habitat is outside nature reserves according to joint MSU-Chinese research
3. NTU and UNSW open joint center to study microorganisms for water and environment technologies
4. U-M joins with Chinese university to jointly fund renewable energy and biomedical research projects
5. DOE Joint Genome Institute 5th Annual Meeting on March 24-26, 2010
6. TNO and Seventh Wave sign letter of intent on joint preclinical pharmaceutical outsourcing services
7. Joint US-Norwegian study provides new insights into marine ecosystems and fisheries production
8. Laser processes promise better artificial joints, arterial stents
9. Joint research into an enzyme that causes genetic diseases
10. Joint statement by German science organizations on green genetic engineering
11. Imperial College London and NTU collaborate to offer joint Ph.D. programs in engineering and science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... processes from digestion to disease resistance. Despite the fact ... on the planet, more is known about belly-button bacteria ... and colleagues working on Panama,s Barro Colorado Island discovered ... home to more than 400 different kinds of bacteria. ... than 7,000 different kinds. , Bacteria in tropical forests ...
(Date:9/15/2014)... CAMBRIDGE, Mass. (September 15, 2014) The so-called ... which makes proteinhas long provided a simplified explanation ... in living organisms. , In reality, of ... the schema first articulated nearly 60 years ago ... DNA,s double-helix structure. For one, there are multiple ...
(Date:9/15/2014)... tapir populations may continue to drop in French Guiana, ... Office National de la Chasse et de la Faune ... reviewed data retrieved from camera traps in the Nouragues ... this data to current harvest rates in the region., ... French Guiana," said Matthias Tobler, a scientist with the ...
Breaking Biology News(10 mins):Smithsonian scientists discover tropical tree microbiome in Panama 2Scientists discover RNA modifications in some unexpected places 2
... R.I., July 28 ForensicSoft, a growing provider ... to announce the formal approval and selection of ... England. ForensicSoft,s products, which increase the speed and ... popularity among digital forensic and security professionals worldwide. ...
... the Caribbean Sea as the Isthmus of Panama arose, ... the Smithsonian Tropical Research Institute and Scripps Institution of ... species could shift from clonal to sexual reproduction it ... years later. Closure of the Isthmus of Panama involved ...
... NC For avid fishermen and anglers, the largemouth ... for minnows. A new study finds that once they ... fish-feeders have remained relatively unchanged compared with their insect- ... in aquatic ecosystems, natural selection put the breaks on ...
Cached Biology News:Nottinghamshire Police First Law Enforcement Agency to Deploy ForensicSoft in United Kingdom 2Nottinghamshire Police First Law Enforcement Agency to Deploy ForensicSoft in United Kingdom 3Sex in the Caribbean: Environmental change drives evolutionary change -- eventually 2Freshwater fish at the top of the food chain evolve more slowly 2Freshwater fish at the top of the food chain evolve more slowly 3
(Date:9/16/2014)... 2014 According to Jeff Howell, Partner ... ITRA Global, new development in Downtown Toronto is expanding ... approving another 755 storeys of new development last week ... will be dominating the Toronto skyline for the foreseeable ... unquenchable thirst for new development. , As the Toronto ...
(Date:9/16/2014)... September 16, 2014 RENU 28, the world's ... became available for purchase in Australia and New Zealand ... tour beginning September 16th. The tour will make stops in ... Bundaberg on the 18th, Sydney on the 20th, and Melbourne ... Australia and New Zealand and to educate people about the ...
(Date:9/15/2014)... UPTON, NYHeat drives classical phase transitionsthink solid, ... happen when the temperature drops. If phase ... where quantum mechanics reigns, subtle fluctuations can ... from the U.S. Department of Energy,s Brookhaven ... explored this frigid landscape of absolute zero ...
(Date:9/15/2014)... 2014   Global Science & Technology, Inc. ... and services for satellite and weather systems, was ... Services (OASIS) from the General Services Administration (GSA) ... provide the government best-value solutions for complex professional ... in Pool 4. The OASIS SB award has ...
Breaking Biology Technology:ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 2ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 3Global Wellness Company Hosts ASEA Australia Tour September 16-22 2Elusive quantum transformations found near absolute zero 2Elusive quantum transformations found near absolute zero 3Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 3
... - One week before Badger football begins its 2005 ... found a new way to demonstrate their school spirit. The ... with high-powered microscopes. , ,Last month a team of UW-Madison ... an image of the university's mascot made of nanofiber hairs ...
... -- It has been a while since I have had a ... failings in this field is my 13-year-old musician son. As I am ... in my old age, off he went this summer to a week ... of playing rock all day and most of the night? This kind ...
... of Eau Claire, also operating as Online-Kiosks.net, ... channel program that enables resellers and systems integrators ... and subscription services to customers without major investments ... to offer hosted digital signage solutions to their ...
Cached Biology Technology:Nanotechnology minimizes UW's beloved mascot 2Historic lists - The greatest rock bands, rock guitarists of all time 2Historic lists - The greatest rock bands, rock guitarists of all time 3Historic lists - The greatest rock bands, rock guitarists of all time 4
ANTI ALPHA FSH:B...
Collected from normal, healthy animals in carefully maintained standing herds of US orgin. Pricing: $45/unit for 1 - 10 units...
Normal donkey serum collected from healthy normal donkeys....
acridine orange 10-nonyl bromide (nonyl acridine orange)...
Biology Products: