Navigation Links
Casing the joint
Date:9/7/2010

St. Louis, MO Current research provides a novel model for rheumatoid arthritis research. The related report by LaBranche et al, "Characterization of the KRN cell transfer model of rheumatoid arthritis (KRN-CTM), a chronic yet synchronized version of the K/BxN mouse," appears in the September 2010 issue of The American Journal of Pathology.

Nearly 1% of the population is affected by rheumatoid arthritis, and women are affected three to five times more often then men. Although the course of disease varies greatly, daily living activities are impaired in most affected individuals and after 5 years approximately 33% of sufferers are no longer able to work.

Rheumatoid arthritis is characterized by chronic inflammation of the distal joints and is mediated in part by emigration and activation of immune cells. The restrictions of present animal models, which either mimic chronic disease or a synchronized version of early disease (but not both), have hampered scientific understanding of the specific roles immune cells and their mediators play in disease initiation and maintenance. In this regard, Dr. Paul Allen and colleagues at the Washington University in St. Louis School of Medicine, in collaboration with Dr. Timothy LaBranche and colleagues at Pfizer Global Research & Development developed and characterized a chronic yet synchronized animal model of rheumatoid arthritis (KRN-CTM). Disease in these animals developed with a uniform onset of 7 days post-initiation and was maintained chronically (through Day 42). These mice revealed a time course of rheumatoid arthritis characteristics including edema, immune cell infiltration, cartilage damage and osteoclast-mediated bone resorption.

According to Dr. LaBranche, "the main benefit of the KRN-CTM is its utility, which adds significant logistical and platform advantages to study T cell targets since the model is T cell-dependent and engages both early and late stages of innate and ad
'/>"/>

Contact: Angela Colmone, Ph.D.
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1 2

Related biology news :

1. BIO-key(R) International Showcasing Biometric Identification Technology at 2009 RSA Conference
2. Most panda habitat is outside nature reserves according to joint MSU-Chinese research
3. NTU and UNSW open joint center to study microorganisms for water and environment technologies
4. U-M joins with Chinese university to jointly fund renewable energy and biomedical research projects
5. DOE Joint Genome Institute 5th Annual Meeting on March 24-26, 2010
6. TNO and Seventh Wave sign letter of intent on joint preclinical pharmaceutical outsourcing services
7. Joint US-Norwegian study provides new insights into marine ecosystems and fisheries production
8. Laser processes promise better artificial joints, arterial stents
9. Joint research into an enzyme that causes genetic diseases
10. Joint statement by German science organizations on green genetic engineering
11. Imperial College London and NTU collaborate to offer joint Ph.D. programs in engineering and science
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... from strains of influenza virus increases with the latest ... complacent that the most substantial threats have been identified, ... arise when a new virus strain – against which ... in the human population. There have been five such ... which – the 1918 Spanish Flu – cost 50 ...
(Date:10/15/2014)... pneumonia in female mice to an enzyme activated by ... more resistant to respiratory infections than males. Now, an ... to bacterial pneumonia in female mice is linked to ... show that this enzyme is ultimately activated by the ... team, lead by Professor Lester Kobzik at the Harvard ...
(Date:10/14/2014)... Like discriminating thieves, prostate cancer tumors scavenge and hoard ... But such avarice may be a fatal weakness. ... to kill prostate cancer cells by delivering a trove ... the diseased cells brimming with the mineral, leaving non-cancer ... drugs already commercially available for other uses, could soon ...
Breaking Biology News(10 mins):Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Prostate cancer's penchant for copper may be a fatal flaw 2
... the competition between native and invasive plants growing in deciduous ... the plants cross the finish line in autumn., A new ... leaves of invasive plants continue to function in the fall, ... winter. The findings are counter to conventional wisdom, which held ...
... at the upper end of the typical pain scale ... intensity, pain is debilitating. Yet many sufferers do not ... and commonly prescribed pain medications. Recently, a team ... of biomedical engineering in CCNY,s Grove School of Engineering, ...
... from the IPM in Tehran and the University of Cambridge, ... of disordered, frozen electric charges can make a difference when ... charges induce a twisting force that is strong enough to ... These results, about to be published in EPJ E (1), ...
Cached Biology News:Syracuse University study finds autumn advantage for invasive plants in eastern United States 2Syracuse University study finds autumn advantage for invasive plants in eastern United States 3Technology eases migraine pain in the deep brain 2
(Date:10/18/2014)... October 18, 2014 The Biomass ... in the five years to 2014. The industry's expansion ... energy tax credits that encouraged the use of biomass ... portfolio standards (RPSs), which require local utilities to generate ... total energy portfolio. Increased campaigning for green technology also ...
(Date:10/18/2014)... 2014 The report " Cloud ... Text; Web; Speech; Machine; Video; Predictive Analytics: Global ... Forecasts & Analysis (2013 - 2018) ", defines ... various sub segments with an in-depth analysis and ... the factors driving this market, various restraints, and ...
(Date:10/17/2014)... received a $451,781 Air Force Office of Scientific Research ... and nano-scale level that will provide clues for predicting ... and Aerospace Engineering, said the new technology and process ... of an aircraft,s wing., "We,ll be able to determine ... at it on this scale," Huang said. "Certain patterns ...
(Date:10/17/2014)... and HILDEN, Germany ...   , Translational research in cancer ... being presented at the American Society of Human ... 250,000-plus DNA samples linked to Ingenuity ®  Knowledge ... for genomic analysis  Ingenuity ®  Variant ...
Breaking Biology Technology:Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5UT Arlington project to detect possible damages in aircraft parts early in process 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 3QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 4QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 5QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 6
... the fossil fuels economy, Wisconsin is a donor state. There's ... terrain, so millions of dollars leave Wisconsin every day to ... our fossil fuel age. , ,Wisconsin's donor-state status isn't going ... governments, and citizens to conserve. While part of the answer, ...
... ticking on the 18-month window for Midwest Fiber Networks ... service. , ,After months of indecision and the courting of ... Cellnet , Mayor Tom Barrett decided to sign a contract ... build a $20 million "Wi-Fi" network, starting with a demonstration ...
... Software , a Merge Healthcare company and ... a new version of its digital imaging and communications ... a software development kit (SDK) that now supports Microsoft's ... software applications. , ,DICOM is a set of standards ...
Cached Biology Technology:State should keep open mind on nuclear power 2State should keep open mind on nuclear power 3State should keep open mind on nuclear power 4Milwaukee could be wireless in 18 months 2