Navigation Links
Case researcher in RNA biology makes waves by challenging current thinking
Date:1/18/2008

offers a better understanding of this mRNA quality control process which closely mimics the process in human cells.

Bakers research on nonsense-mediated mRNA decay not only provides an advanced understanding of an important process in the regulation of gene expression, but may help lead to new therapeutic strategies in the treatment of genetic diseases. Many inherited conditions, including cystic fibrosis, are a consequence of mutations resulting in the recognition of non-functional mRNA and the subsequent elimination by nonsense-mediated mRNA decay. Because cells eliminate the abnormal mRNA, no protein is produced. With genetic diseases, researchers are hypothesizing it might be beneficial for the cell to express the protein, even though it is not completely functional. The rational is it will be better for these patients to have protein of some function rather than no protein at all. Cystic fibrosis clinical trials are currently underway with a goal of producing the partially functional proteins, before the cells natural elimination process takes place. Using Bakers findings, researchers will have a better understanding of how to modulate the recognition of the abnormal mRNAs as to allow the mRNA to remain in the cell and produce the protein.

This finding is an important step in advancing our understanding of mRNA function, said Baker. In addition, it emphasizes the important link between basic and clinical science; the more we understand the basic biological processes that are underway in the cell, the better equipped we are to directly address clinical therapies.


'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
6. U of MN researchers discover noninvasive diagnostic tool for brain diseases
7. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
8. Researchers discover new strategies for antibiotic resistance
9. Researchers find new taste in fruit flies: carbonated water
10. Binghamton University researchers investigate evolving malaria resistance
11. Antioxidant to retard wrinkles discovered by Hebrew University researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... scars on this false-color image from the Terra satellite show ... rash of wildfires in Eastern Russia. The burn scars ... background. The wildfires have broken across the remote parts ... this false-color image from the MODIS instrument, it is ... that continue. Two recent image features noted below show the ...
(Date:7/25/2014)... the International Journal of Cancer earlier this ... based on findings showing successful reduction in the risk ... of cells in the cervix. , The findings ... cells, or SCJ cells. These cells reside in the ... of cervical cancer. A research team co-led by Christopher ...
(Date:7/25/2014)... and Diabetes increasingly consume the healthcare community ... attention. , To address the worldwide ... low-and middle-income countries, global leaders in diabetes, ... in diabetes prevention and development of diverse ... text. , This book on "Global ...
Breaking Biology News(10 mins):Clearing cells to prevent cervical cancer 2What constitutes an effective response to the global 'diabesity' tsunami? 2
... highways or drive down any city street this ... manicured beds of flowers maintained by community volunteers ... gardens are taking root. Aside from the ... including landscaping and gardens, can help drivers reduce ...
... University doctoral student Jennifer Smith has shed new light on ... hunt for their food alone. In a paper ... a student in MSU,s Department of Zoology, shows that while ... cooperative societies, they also realize that venturing on their own ...
... 28, 2008The 2008 American Society for Microbiology (ASM) ... being presented to Stephen C. Edberg, Professor, Department ... School of Medicine, and Director, Clinical Microbiology Laboratory, ... this award recognizes a distinguished scientist for research ...
Cached Biology News:New roadside beautification concept studied 2Spotted hyenas can increase survival rates by hunting alone 2American Society for Microbiology honors Stephen C. Edberg 2
(Date:7/24/2014)... Calabasas, CA (PRWEB) July 24, 2014 ... advancing the Global Supply Chain of the biotech ... annual SCM Innovation Awards, brought to you by ... premiere global organization of supply chain management professionals ... be given to stakeholders of the Biotech industry ...
(Date:7/24/2014)... team led by group leader Yung-Eun Sung has ... synthesize sulfur-doped and nitrogen-doped graphenes which can be ... and fuel cells. Yung-Eun Sung is both a ... at Institute for Basic Science* (IBS) and a ... achievement has great significance with regards to the ...
(Date:7/24/2014)... 24, 2014 Research and Markets ... and Proteomics Analytical Instruments Market 2014-2018" report to ... Genomics is the study of the gene ... the structure and functions of proteomes or sets of ... technology. Genomics involves the mapping of genes and DNA ...
(Date:7/24/2014)... 2014 2014 Deep Research Report ... a professional and in-depth research report on Potassium ... basic information, including its definition, classification, application, ... research covers the international market analysis, including China’s ... covering macroeconomic environment & economic situation analysis, the ...
Breaking Biology Technology:Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4
... German . The heat which occurs in ... even a problem. On the contrary: It could be used ... more efficiently! These are two of the several potential applications ... (PTB). This so-called "thermoelectric voltage" may well be very interesting ...
... Spherix Incorporated (NASDAQ: SPEX ) ... diabetes, metabolic syndrome and atherosclerosis, and providers of ... biotechnology and pharmaceutical companies -- today announced that ... dyslipidemia in new studies of apolipoprotein E-deficient mice ...
... Oct. 24, 2011 Reaction Biology Corporation ("RBC"), ... services in epigenetics, today announced the rollout of ... research. RBC,s initial offerings will emphasize the histone ... has been no previous commercial source. ...
Cached Biology Technology:Magnetic nanoswitch for thermoelectric voltages 2Spherix Announces Results from New Preclinical Studies Showing SPX-106T Produces Significant Reductions in Cholesterol, Fat Deposition and Body Weight 2Spherix Announces Results from New Preclinical Studies Showing SPX-106T Produces Significant Reductions in Cholesterol, Fat Deposition and Body Weight 3Spherix Announces Results from New Preclinical Studies Showing SPX-106T Produces Significant Reductions in Cholesterol, Fat Deposition and Body Weight 4Reaction Biology Launches Recombinant Methyltransferase Line 2
... ESGRO Complete Derivation Kit is intended ... cells from delayed blastocysts in serum-free ... Clonal Grade ... Blastocyst Incubation Medium Trypsin Solution ...
AedestaTM Animal Organ/Tissue Perfusion Soln....
RAT ANTI MOUSE JAM-2 Immunogen: Recombinant soluble JAM-2...
casein kinase 2, alpha 1 polypeptide, transcript variant 2, mRNA (cDNA clone MGC:15232 IMAGE:4121882), complete cds...
Biology Products: