Navigation Links
Case Western Reserve researchers looking at light-induced toxins in air and water
Date:2/17/2009

l exhaust and urban air pollution is associated with an increased risk of lung cancer," Crespo says, noting that laboratory mammals and in vitro tests have found the compounds to be toxic, mutagenic and even carcinogenic.

Previous research works have shown that light-induced degradation of a number of nitro-aromatic compounds leads to products that are more toxic than their parent compounds. Further evidence suggests that these pollutants contribute as much as 10% of the total mutagenicity of inhalable, suspended particles in polluted areas. However, the specific pathways through which these compounds are transformed into products by sunlight are not well understood.

The Crespo group expects that by using sophisticated laser techniques with less than a trillionth of a second time resolution, in combination with computations based on quantum mechanical theories, a better understanding of the fundamental processes controlling the light-induced transformation of these pollutants can be obtained.

"Once we understand the physico-chemical factors that control the degradation of these compounds by light absorption at the molecular level, we might be able to use this knowledge to reduce some of these chemical transformations."

It is known that these compounds can release a nitric oxide (NO) radical when exposed to light. Crespo says one of the long-term goals of this research is to harness the power of these radical compounds for biological applications.

"Once we understand the factors that control the release of NO radicals, we could envision the use nitro-aromatic compounds as light-triggered, time- and site-controlled NO radical donors for therapeutic applications," he says. "But we are currently a long way from that."

Their 2008 paper, "Environmental Photochemistry of Nitro-PAHs: Direct Observation of Ultrafast Intersystem Crossing in 1-Nitropyrene," was one of the first scholarly works using femtosecond laser
'/>"/>

Contact: Jason A. Tirotta
jason.tirotta@case.edu
216-368-6890
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
2. Natural brain substance blocks weight gain in mice, UT Southwestern researchers discover
3. Climate changes impact on invasive plants in Western US may create restoration opportunities
4. Tree deaths have doubled across the western US
5. Study finds MRSA in Midwestern swine, workers
6. UT Southwestern scientist honored among best in Texas research
7. Case Western Reserve finds mechanism underlying alt. splicing of premessenger RNA into messenger RNA
8. UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
9. Deranged calcium signaling contributes to neurological disorder, UT Southwestern researchers find
10. Case Western Reserve University uncovers genetic basis for some birth defects
11. NSF grant to launch undergrads from Case Western Reserve into math and science teaching
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/12/2014)... Nov. 12, 2014 Crossmatch™, a leading provider ... U.are.U ® fingerprint readers have been deployed throughout ... Central Mexico . The bakery chain implemented ... payroll issues caused by employees clocking in for each ... fingerprint readers, Montparnasse relied on paper timecards and a ...
(Date:11/7/2014)... Florida , November 6, 2014 ... authentication for better mobile security revolutionizing online transactions.  Companies in ... Alibaba Holdings Ltd. (NYSE: BABA ), Google Inc. ... MSFT ), eBay Inc. (NASDAQ: EBAY ) and ... NXTD and NXTDW), a biometric authentication company focused ...
(Date:11/5/2014)... of biology in the UTSA College of Sciences, ... selected to receive a two-year $300,00 National Science ... (EAGER). The funding supports President Obama,s BRAIN Initiative, ... new technology that will demystify complex brain processes. ... neuroscience are broken into the interactions of multiple ...
Breaking Biology News(10 mins):Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3
... international collaboration effort in Mongolia to be used in ... collected from wild birds in Mongolia by field veterinarians ... have been selected by the World Health Organization to ... currently in development. The samples, collected in ...
... of the body's primary strategies for regulating its genome ... small molecules called microRNAs, or miRNAs. First observed only ... messenger RNA, itself responsible for translating genes into proteins. ... clearly important players on the genetic field despite having ...
... a study in Botswana, Harvard School of Public Health ... in resource-poor settings, who receive antiretroviral (ARV) therapy, can ... A fully supported health care delivery system and infrastructure ... November 2005 issue of the Journal of Acquired Immune ...
Cached Biology News:Wild birds help to create human flu vaccine 2Wild birds help to create human flu vaccine 3Twin molecular scissors link creation of microRNAs with gene-silencing 2Largest computational biology simulation mimics life’s most essential nanomachine 2
(Date:11/26/2014)... 2014 Whitehouse Laboratories is pleased ... Morris County (New Jersey) Chamber of Commerce as ... business organization in the North Jersey area, offers ... some key clients in the pharmaceutical and biotechnology ... area. Membership enables Whitehouse Laboratories a higher level ...
(Date:11/26/2014)... (PRWEB) November 25, 2014 Continuing its ... products, earned three prestigious MarCom Awards for outstanding creative ... received a Platinum MarCom Award, the organization’s top honor, ... in St. Louis held in April of this year. ... than 14,000 attendees. Additionally, Nerium was awarded a Gold ...
(Date:11/26/2014)... West Chester, OH (PRWEB) November 25, 2014 ... International Holdings, has joined the Graphel Carbon Products team ... experience in sales, marketing, and customer service for the ... to add Miles to our team,” stated Dave Trinkley, ... Products. “His wide range of experience in the ...
(Date:11/26/2014)... 2014 Deep Research Report on ... report on the Global Palmitic Acid industry. For ... basic information, including definition, classification, application, industry chain ... etc. , For international and China market ... in China and other countries or regions ...
Breaking Biology Technology:Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2Miles Holder Joins Graphel Corporation as Sales/Marketing Manager 2Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 2Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 3
... EORTC-NCI-AACR Symposium -, SOUTH SAN FRANCISCO, ... Pharmaceuticals, Inc. (Nasdaq: PARD ), a ... incremental data from,its ongoing Phase 2 clinical ... prednisone as first-line therapy for metastatic,hormone-refractory prostate ...
... National Institutes of Health, SAN DIEGO, Oct. ... of a $28 million contract from the National ... of the National,Institutes of Health, for the development ... Under the five-year,contract, Trius will develop novel drugs ...
... Cadence Pharmaceuticals,Inc. (Nasdaq: CADX ), a biopharmaceutical ... candidates principally,for use in the hospital setting, announced ... will present the company,s corporate,overview on Tuesday, October ... during the BIOCOM Investor Conference at the Hyatt ...
Cached Biology Technology:Poniard Announces Positive Incremental Efficacy and Safety Data From Ongoing Phase 2 Picoplatin Trial in Hormone-Refractory Prostate Cancer 2Poniard Announces Positive Incremental Efficacy and Safety Data From Ongoing Phase 2 Picoplatin Trial in Hormone-Refractory Prostate Cancer 3Poniard Announces Positive Incremental Efficacy and Safety Data From Ongoing Phase 2 Picoplatin Trial in Hormone-Refractory Prostate Cancer 4Poniard Announces Positive Incremental Efficacy and Safety Data From Ongoing Phase 2 Picoplatin Trial in Hormone-Refractory Prostate Cancer 5Trius Awarded $28 Million Contract to Develop Novel Antibiotics 2Cadence Pharmaceuticals' CEO Theodore Schroeder to Present at the BIOCOM Investor Conference 2
... DNA Polymerase is ideal for high-fidelity ... applications such as cloning and mutagenesis. ... a proprietary enzyme preparation containing recombinant ... proofreading (3'Cut Site5' exonuclease) activity. ...
... BV-10 offers precision beveling of ... 50m. The unique abrasive plate ... for greater control of the ... accomplished very rapidly and produces ...
... 2 mM sodium phosphate buffer, pH 6.5. ... is a major lysosomal aspartyl protease in ... proenzyme. Overexpression of cathepsin D in human ... of relapse and metastasis. Cathepsin D degrades ...
Rat Hepatocytes (RH) (>3,000,000 cells)...
Biology Products: