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Case Western Reserve researchers develop 'wireless' activation of brain circuits
Date:2/23/2009

aper, "Wireless Activation of Neurons in Brain Slices Using Nanostructured Semiconductor Photoelectrodes," is the first report of brain stimulation using light-activated semiconductor nanoparticles. This research study was published in Angewandte Chemie, a premier chemistry journal. The journal also highlighted the study as a "hot paper."

This study used brain slices to show that light can trigger neural activity. The next step is to see if this innovative technology can be used to stimulate longer pathways within the intact brain. Clinical development of the technology could lead to new methods to activate specific brain regions and damaged nerves.

"The long-term goal of this work is to develop a light-activated brain-machine interface that restores function following nerve or brain impairments," Strowbridge says. "The first attempts to interface computers with brain circuitry are being done now with complex metal electrode stimulation arrays that are not well suited to recreating normal brain activity patterns and also can cause significant damage."

Currently light is being used in the study to drive neural activity in a minimally invasive manner, without requiring electrical wires.

The pair credits Pamela Davis, dean of the School of Medicine, for introducing them several years ago. "It is great to have a medical school dean who knows not only what her own faculty are doing but also closely follows the research programs in other colleges," says Strowbridge. Campus geography played a role as well. "This project would not have happened without the close physical proximity between the two departments," says Burda. "Case Western Reserve is unusual in having its medical school located on the same campus as the rest of the University."

When they aren't brought together for this collaboration, the two labs pursue vastly different research programs. Strowbridge's laboratory is interested in how groups of
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Contact: Jason A. Tirotta
jason.tirotta@case.edu
216-368-6890
Case Western Reserve University
Source:Eurekalert

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