Dr. Nadeau's work, on which the Pioneer Award is based, has shown that this unconventional mode of inheritance rivals conventional genetics in its impact on biological variation and disease risk. The major challenge now is to identify the molecular basis for these effects and to determine whether a similar mode of inheritance occurs in humans.
"NIH is pleased to be supporting scientists from across the country who are taking considered risks in a wide range of areas in order to accelerate research. We look forward to the results of their work," says NIH Director Francis S. Collins, MD, PhD.
Dr. Nadeau's research focus throughout his career has involved the genetics of mouse models of common human diseases and conditions, such as cancers, obesity and metabolic diseases, as well as birth defects. His work has relied on creating specially engineered mice and developing special computational methods and databases. But through these various studies, over many years, a growing sense emerged that current thinking and evidence was incomplete, and that other as yet unidentified factors and mechanisms were in play.
This year's recipients of the NIH Director's Pioneer Awards will join the 81 Pioneers selected since the start of each program in 2004. These awards support individual scientists of exceptional creativity who propose pioneering and possibly transforming approaches to major challenges in biomedical and behavioral research. The NIH selects recipients through special application and evaluation processes. Distinguished outside experts identify the most highly competitive applicants.
|Contact: Jessica Studeny|
Case Western Reserve University