Navigation Links
Case Western Reserve geneticist receives prestigious NIH Director's Pioneer Award
Date:8/6/2010

Noted geneticist, Joseph Nadeau, PhD, of Case Western Reserve University School of Medicine, has received a 2010 National Institutes of Health (NIH) Director's Pioneer Award.

One of 17 awardees to receive this prestigious distinction, Dr. Nadeau will investigate transgenerational genetic effects, where the biological features and disease risk of an individual has been found to depend as much on the genetics of ancestral generations as on their own inherited genes. His discovery of this unexpected mode of inheritance challenges the most fundamental premise of most studies where an individual's genes, environmental exposures and life experiences are customarily thought to determine their health status.

"This NIH Director's Pioneer Award is a once-in-a-lifetime opportunity to study this new mode of inheritance" says Dr. Nadeau, the James H. Jewel Professor and Chair of Genetics Department. The five-year grant is supported by an award of $3.9 million.

An enormous international effort is currently underway to discover the genetic basis for common human diseases. While many important discoveries have been made, most of the genes have eluded discovery. As a result, the goal of diagnosing, treating and preventing common birth defects and adult diseases remains unfulfilled.

Discovery of transgenerational genetic effects helps reconcile the general sense that traits and diseases 'run' in families. That is, having a family member with a disease dramatically increases the inherited risk for everyone else in the family. Although familial occurrence remains the single strongest factor for disease risk, these genes have proven extraordinarily hard to find, a problem that has been called 'missing heritability'. If these genetic variants act across generations, as Dr. Nadeau's evidence suggests, then traits can still have a genetic basis, but the 'disease genes' may present themselves in previous generations and not necessarily in the affected individuals, which would be a revolutionary discovery.

Dr. Nadeau's work, on which the Pioneer Award is based, has shown that this unconventional mode of inheritance rivals conventional genetics in its impact on biological variation and disease risk. The major challenge now is to identify the molecular basis for these effects and to determine whether a similar mode of inheritance occurs in humans.

"NIH is pleased to be supporting scientists from across the country who are taking considered risks in a wide range of areas in order to accelerate research. We look forward to the results of their work," says NIH Director Francis S. Collins, MD, PhD.

Dr. Nadeau's research focus throughout his career has involved the genetics of mouse models of common human diseases and conditions, such as cancers, obesity and metabolic diseases, as well as birth defects. His work has relied on creating specially engineered mice and developing special computational methods and databases. But through these various studies, over many years, a growing sense emerged that current thinking and evidence was incomplete, and that other as yet unidentified factors and mechanisms were in play.

This year's recipients of the NIH Director's Pioneer Awards will join the 81 Pioneers selected since the start of each program in 2004. These awards support individual scientists of exceptional creativity who propose pioneering and possibly transforming approaches to major challenges in biomedical and behavioral research. The NIH selects recipients through special application and evaluation processes. Distinguished outside experts identify the most highly competitive applicants.

More information on the Pioneer Award is at http://nihroadmap.nih.gov/pioneer and on the New Innovator Award is at http://nihroadmap.nih.gov/newinnovator.


'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. Pancreatic cancers use fructose, common in the Western diet, to fuel their growth
2. UT Southwestern researchers find key step in bodys ability to make red blood cells
3. Case Western Reserve awarded $4.7 million from Defense Advanced Research Projects Agency
4. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
5. Temperature and salt levels of the Western Mediterranean are on the increase
6. UT Southwestern researchers find mechanism that may stop E. coli from developing in cattle
7. UT Southwestern researchers identify key molecular step to fighting off viruses
8. Case Western Reserve team discovers smart insulin molecule
9. UT Southwesterns BioCenter driving biotech, medical innovation in North Texas
10. New brain nerve cells key to stress resilience, UT Southwestern researchers find
11. UT Southwestern student receives fellowship from Howard Hughes Medical Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television series will ... American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global population estimates ... of how to continue to feed a growing nation. At the same time, many ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses the surface electromyography ... generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The prospective multicenter phase ...
(Date:10/7/2017)...  The 2017 Nobel Prize in Chemistry recognizes ... Joachim Frank and Richard Henderson ... (cryo-EM) have helped to broaden the use ... The winners worked with systems manufactured by Thermo ... resolved, three-dimensional images of protein structures that lead ...
(Date:10/5/2017)... YORBA LINDA, CA (PRWEB) , ... October 05, 2017 , ... ... tech innovators, engineers, and scientists from around the world, is giving back to cancer ... shirt sold in October. , Now through October 31, shoppers can use promo ...
Breaking Biology Technology: