Navigation Links
Case Western Reserve finds mechanism underlying alt. splicing of premessenger RNA into messenger RNA
Date:12/24/2008

two clusters. That more than 130 potential mRNA's could be prevented from being manufactured was highly unexpected. That means that small changes in a nucleotide sequence near a splice point can lead to large changes in splice site choice and proteins produced.

If one considers the metaphor that pre-mRNA is a long sentence, Nilsen says, then nucleotides and splice sites are the words of the sentence. "Adding or deleting one word," he says, "can radically change the meaning of the sentence."

According to Joseph Nadeau, Ph.D. chair of the genetics department in the School of Medicine, the most important conclusion of Nilsen's research is that "it's context, not code that's important." He says the current assumption of biologists is that there are rules that govern biological phenomena like alternative splicing, and those rules are hidden in the DNA code. So as soon as we break the code, this assumption predicts, we will be able to control alternative splicing and start curing the genetic diseases it causes.

In Nilsen's view, the contextthe changes in no more than two dozen nucleotides near a possible splice pointis part of the genetic code. His team's discovery means that the code is much more complicated than scientists ever anticipated, and that fact will likely delay the day scientists can begin to intervene in the code to cure genetic diseases.


'/>"/>

Contact: Christina DeAngelis
christina.a.thompson@case.edu
216-368-3635
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Western diet linked to increased risk of colon cancer recurrence
2. UT Southwestern researchers identify hundreds of genes controlling female fertility
3. Northwestern to expose most deadly infectious diseases in 3-D
4. Northwestern study looks at sensing, movement and behavior
5. Tiny dust particles from Asian deserts common over western United States
6. Threatened bird species finds home at Western
7. BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests
8. UT Southwestern secures $5 million NIH grant for lupus research
9. UT Southwestern scientist honored among best in Texas research
10. Western Groundfish Conference to be held in Santa Cruz on Feb. 4-8
11. Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... Huntington Memorial Hospital is the first facility ... miniaturized, wireless monitoring sensor to manage heart failure (HF). ... FDA-approved heart failure monitoring device that has been proven ... to manage heart failure. The CardioMEMS HF ... pulmonary artery (PA) during a non-surgical procedure to directly ...
(Date:4/14/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... York Design Awards under the category  ,Product Design – ... Awards are part of a global multi-disciplinary awards program. ... the marketplace, industry and judging panel. Winners will be ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... April 23, 2015, after the close of market. The ... and investors at 2:00 p.m. PT (5:00 p.m. ET), ... To participate on the live call, analysts and ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3Synaptics to Report Third Quarter Results on April 23 2
... study of apex predators in the Pacific Ocean found ... previously thought, unknown relationships between other species, and the ... of these sea creatures. The field program, dubbed ... at 23 species from 2000-09 and included researchers from ...
... WI, JUNE 22, 2011 -- Vinyl chloride is a ... anaerobic conditions. These solvents are used in many industrial ... most encountered groundwater pollutants in industrialized countries. Groundwater is ... to determine if vinyl chloride can be further degraded ...
... by psychologists at the University of Toronto and Tufts University ... sexual orientation when looking at his face, when she is ... thoughts or a mating goal heightens a woman,s ability to ... not apparent when a woman is judging another female,s orientation," ...
Cached Biology News:Decade-long study of Pacific predators shows importance of biological 'hotspots' 2Decade-long study of Pacific predators shows importance of biological 'hotspots' 3Psychologists find link between ovulation and women's ability to identify heterosexual men 2
(Date:4/28/2015)... April 28, 2015 The Pistoia Alliance, ... work together to lower barriers to innovation in R&D, ... project. , The Ontologies Mapping project has been ... practices for ontology management in life sciences R&D. The ... of standardized guidelines, tools and services to enable the ...
(Date:4/28/2015)... According to a 2013 report from ... medical treatment from burn injuries per year. Despite several ... formation of scars with subsequent contractures remains a major ... there is no adequate treatment. Contractures are a permanent ... can cause permanent deformity. , Synedgen has developed ...
(Date:4/28/2015)... 28, 2015 Reproductive endocrinologist Dr. Kaylen ... 7 couples battling infertility in this country, testified on behalf ... as the first state in the nation to consider creating ... to couples who desire to receive them. , Infertility affects ... that infertility is one of the few medical diseases that ...
(Date:4/27/2015)... HEIDELBERG , Alemania, April 27, 2015 ... patente para un nuevo receptor utilizando tecnología de descubrimiento ... no cubierta en el tratamiento de millones de pacientes ... anunciado hoy que ha recibido una patente en Europa ... el descubrimiento de Molecular Health de que EPHB4 es ...
Breaking Biology Technology:Pistoia Alliance Announces Start of Ontologies Mapping Project 2Synedgen Burn Treatment Results Presented at Premier Wound Conference 2Synedgen Burn Treatment Results Presented at Premier Wound Conference 3Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 2Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 3Molecular Health obtiene la patente para un nuevo receptor 2Molecular Health obtiene la patente para un nuevo receptor 3
... THOR ), a world leader in device-based mechanical,circulatory ... announced that it will report its operating results for ... on Thursday, October 30., The company will hold ... activities to all interested parties at 1:30 p.m.,Pacific Daylight ...
... QUEBEC CITY, Oct. 24 /PRNewswire-FirstCall/ - AEterna Zentaris ... biopharmaceutical company focused on,endocrine therapy and oncology, today ... Stock Market, notifying AEterna Zentaris that during the ... the bid price of the,Company,s common shares had ...
... Fastest-Growing Companies, TUSTIN, Calif., Oct. 24 ... a vertically integrated pharmaceutical company with major,operations in ... been recognized by,Deloitte LLP as the 6th fastest ... Technology Fast 50 Program., This nationally-recognized program ...
Cached Biology Technology:Thoratec Schedules Third Quarter 2008 Conference Call, Webcast 2AEterna Zentaris Receives Notification from Nasdaq Relating to Minimum Bid Price 2AEterna Zentaris Receives Notification from Nasdaq Relating to Minimum Bid Price 3AMDL, Inc. Named to Deloitte LLC Technology Fast 50 2AMDL, Inc. Named to Deloitte LLC Technology Fast 50 3AMDL, Inc. Named to Deloitte LLC Technology Fast 50 4