Navigation Links
Case Western Reserve finds mechanism underlying alt. splicing of premessenger RNA into messenger RNA
Date:12/24/2008

two clusters. That more than 130 potential mRNA's could be prevented from being manufactured was highly unexpected. That means that small changes in a nucleotide sequence near a splice point can lead to large changes in splice site choice and proteins produced.

If one considers the metaphor that pre-mRNA is a long sentence, Nilsen says, then nucleotides and splice sites are the words of the sentence. "Adding or deleting one word," he says, "can radically change the meaning of the sentence."

According to Joseph Nadeau, Ph.D. chair of the genetics department in the School of Medicine, the most important conclusion of Nilsen's research is that "it's context, not code that's important." He says the current assumption of biologists is that there are rules that govern biological phenomena like alternative splicing, and those rules are hidden in the DNA code. So as soon as we break the code, this assumption predicts, we will be able to control alternative splicing and start curing the genetic diseases it causes.

In Nilsen's view, the contextthe changes in no more than two dozen nucleotides near a possible splice pointis part of the genetic code. His team's discovery means that the code is much more complicated than scientists ever anticipated, and that fact will likely delay the day scientists can begin to intervene in the code to cure genetic diseases.


'/>"/>

Contact: Christina DeAngelis
christina.a.thompson@case.edu
216-368-3635
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Western diet linked to increased risk of colon cancer recurrence
2. UT Southwestern researchers identify hundreds of genes controlling female fertility
3. Northwestern to expose most deadly infectious diseases in 3-D
4. Northwestern study looks at sensing, movement and behavior
5. Tiny dust particles from Asian deserts common over western United States
6. Threatened bird species finds home at Western
7. BMI criteria for obesity surgery should be lowered, UT Southwestern researcher suggests
8. UT Southwestern secures $5 million NIH grant for lupus research
9. UT Southwestern scientist honored among best in Texas research
10. Western Groundfish Conference to be held in Santa Cruz on Feb. 4-8
11. Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... WINSTON-SALEM, N.C. , March 12, 2015 ... afternoon at Brenner Children,s Hospital, part of Wake Forest ... an outreach initiative for the 2015 ACC Men,s Basketball ... taking pictures with them and getting their autographs. ... Wake Forest Baptist. It is the only children,s hospital ...
(Date:3/11/2015)... March 11, 2015   The Sync Project™ ... to scientifically measure and harness music to improve ... biometrics and objective measurements of physiology, enabling the ... scale in large populations. It is designed for ... clinicians perform rigorous studies and accelerate the discovery ...
(Date:3/10/2015)... OXFORD, Conn. , March 10, 2015 /PRNewswire/ ... NXTDW) ("NXT-ID" or the "Company"), a biometric authentication ... reports the company,s Wocket™ smart wallet has been ... 2015" by Rethink Modern. Rethink Modern ... sharing modern and innovative items for your home and lifestyle that ...
Breaking Biology News(10 mins):Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4
... University of Illinois at Chicago College of Medicine have discovered ... to create the devastation of Huntington,s disease. The report of ... The researchers were able to show that the mutated ... expressed only in neurons and, further, to show what effect ...
... There won,t be anymore waiting in the dark at this ... by a group of engineering researchers at McMaster University has ... The researchers are also hoping that the prototype ... The bus shelter is located on the west side of ...
... out as individuals and leave telltale signs of our ... are fingerprints really for? According to Roland Ennos, from ... have fingerprints and some South American monkeys have ridged ... fingerprints are there to help us hang onto objects ...
Cached Biology News:Huntington's disease deciphered 2Huntington's disease deciphered 3Flexible solar strips light up campus bus shelter 2Urban myth disproved: Fingerprints do not improve grip friction 2
(Date:3/26/2015)... CA (PRWEB) March 26, 2015 PRC ... (CRO), announced today several management and executive appointments effective ... Chief Financial Officer (CFO) and member of the Board ... of Business Operations, and Sue Dowden will assume the ... co-founder and current Chief Operations Officer (COO), has been ...
(Date:3/26/2015)...  BioNano Genomics, Inc., the leader in genome mapping, ... chief commercial officer. Salyer has more than 20 years ... life sciences. At BioNano, Salyer will oversee the commercialization ... to assemble a comprehensive view of complex genomes to ... institutions located in the United States ...
(Date:3/26/2015)... 26, 2015 PAREXEL International Corporation ... clinical research organization , announced today that ... to acquire all of the business assets of ... provider of specialized pharmacovigilance services, based in ... detection, assessment, monitoring, and prevention of adverse ...
(Date:3/26/2015)... Ale Gicqueau, Founder and President of ... Affairs at Align Technology, on “ Conducting Postmarket Registries ... 2015 Global Conference and Exhibition on April 25th through ... During the poster presentation, Ale Gicqueau and Victor Chen ... Postmarket Registry, the requirements and resources to conduct the ...
Breaking Biology Technology:PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 2PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 3BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3
... 14 Neurocrine Biosciences,Inc. (Nasdaq: NBIX ) announced ... been appointed President and Chief Executive,Officer and a member ... will step down as President and Chief Executive Officer ... of the Board of,Directors., "While this was a ...
... Industry Ltd. (Nasdaq: SHMR ) ("Shamir"), a ... progressive ophthalmic lens,market, announced today that its board ... aggregate amount of US$ 4.0 million (approximately NIS,15.1 ... rate of,exchange), or approximately US$ 0.243 (approximately NIS ...
... ... Meet Growing Global Demand, WILMINGTON, Del., Jan. ... Fanandakis group vice president - DuPont Applied,BioSciences. In this newly ... a range of bio-based,products and technologies to meet growing global ...
Cached Biology Technology:Neurocrine Announces Appointment of Kevin Gorman, Ph.D., as President and Chief Executive Officer 2Shamir Optical Industry Ltd. Announces Declaration of a Cash Dividend 2Shamir Optical Industry Ltd. Announces Declaration of a Cash Dividend 3DuPont Names Nicholas Fanandakis as Group Vice President - DuPont Applied BioSciences 2
... Fully automated microarray slide processing offering ... The trend to miniaturization, automation and ... a powerful tool with many applications ... These applications range from gene expression ...
... Thermomixer R offers maximum application versatility ... heating, and cooling. Its active heating/cooling ... and temperature control ranges. Five different ... micro test tubes, are available for: ...
... Protein DetectorTM Microarray Dot Blot Kits ... accuracy and quantitation over a wide range ... formats ) detection. They are ideal ... profiling hundreds of samples for the presence ...
... is a high quality microarray scanner based on ... rejection and spatial resolution. The DNAscope LM ... cost microarray scanner that is upgradeable to a ... Features: Includes control module (computer), ...
Biology Products: