Navigation Links
Case Western Reserve awarded $4.7 million from Defense Advanced Research Projects Agency
Date:7/30/2010

CLEVELAND July 30, 2010 Jonathan Stamler, MD, Director of the Institute for Transformative Molecular Medicine and the Robert S. and Sylvia K. Reitman Family Foundation Distinguished Chair in Cardiovascular Innovation at the Case Western Reserve University and University Hospitals Harrington-McLaughlin Heart & Vascular Institute, has recently received a $4.7 million contract from the Defense Advanced Research Projects Agency (DARPA) to fund the development of a new class of drugs that will selectively dilate blood cells under hypoxia (lack of oxygen in the body's tissues) and thereby enhance soldiers' performance at high altitude.

"Our blood carries less oxygen at high altitudes," said Dr. Stamler. "And there is not much we can do about it. But if we could improve blood flow in tissues we could deliver more oxygen regardless of how much oxygen the blood carries."

Development of any method to enhance tissue oxygenation at high altitudes must consider the distinction between blood O2 content (how much oxygen the blood carries) and red blood cell (RBC) O2 delivery (primarily a function of blood flow). Oxygen delivery is controlled by a gas called nitric oxide, which is released from RBCs under hypoxia. Nitric oxide dilates blood vessels and thereby improves blood flow.

It's anticipated that the grant will generate new physiologic information on high-altitude adaption and new therapeutic interventions to treat patients suffering from conditions where oxygen delivery is impaired, including heart failure, ischemic heart disease, stroke, sickle cell disease and diabetes.

The study will involve a transdisciplinary team including the department of anesthesia, the division of pulmonary medicine, and the Harrington-McLaughlin Cardiovascular Institute at University Hospitals Case Medical Center, Case Western Reserve School of Medicine's primary clinical affiliate.


'/>"/>

Contact: Christina DeAngelis
christina.deangelis@case.edu
216-368-3635
Case Western Reserve University
Source:Eurekalert

Page: 1

Related biology news :

1. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
2. Temperature and salt levels of the Western Mediterranean are on the increase
3. UT Southwestern researchers find mechanism that may stop E. coli from developing in cattle
4. UT Southwestern researchers identify key molecular step to fighting off viruses
5. Case Western Reserve team discovers smart insulin molecule
6. UT Southwesterns BioCenter driving biotech, medical innovation in North Texas
7. New brain nerve cells key to stress resilience, UT Southwestern researchers find
8. UT Southwestern student receives fellowship from Howard Hughes Medical Institute
9. UT Southwestern researchers find clues to TB drug resistance
10. American pika are thriving in the Sierra Nevada and southwestern Great Basin
11. Plant breeding helps revive western rangelands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
(Date:4/3/2017)... WASHINGTON , April 3, 2017 /PRNewswire-USNewswire/ ... single-cell precision engineering platform, detected a statistically ... cell product prior to treatment and objective ... highlight the potential to predict whether cancer ... prior to treatment, as well as to ...
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
Breaking Biology News(10 mins):
(Date:5/22/2017)... ... May 22, 2017 , ... Baltimore ... of the Maryland Biohealth community in developing and issuing recommendations to grow Maryland's ... BioHealth Innovation Hub by 2023. , The recommendations are contained ...
(Date:5/19/2017)... Philadelphia, PA (PRWEB) , ... May 19, 2017 ... ... for its QED Proof-of-Concept Program. Academic researchers with technologies ripe for commercialization, ... Pennsylvania, New Jersey and Delaware, are encouraged to submit proposals. QED, now in ...
(Date:5/18/2017)... (PRWEB) , ... May 17, ... ... CRO standards with psychonneuroendocrine stress expertise, and further enhances its scientific power ... researcher, Douglas A. Granger, Ph.D., has agreed to join the scientific advisory ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... are more likely to develop Alzheimer’s disease, while men are at greater risk ... this gender-specific neuronal bias is the aim of a research program at Worcester ...
Breaking Biology Technology: