Navigation Links
Case Western Reserve University grants option to startup Thermalin Diabetes Inc.
Date:12/11/2009

CLEVELAND Case Western Reserve University has granted an 18-month, exclusive option to startup Thermalin Diabetes Inc. regarding a portfolio of insulin analogs. The company must reach certain milestones in order to exercise its option to obtain an exclusive license on therapies designed to help patients with diabetes.

Cleveland-based Thermalin Diabetes is developing treatments that it hopes will become an important part of the $12 billion, rapidly growing insulin market. Insulin is a therapeutic protein used to manage blood sugar levels. Innovations in the 1990s led to the introduction of insulin analogs with superior therapeutic performance.

"This is one of the coolest technologies that we've seen, because of the potential to serve mankind," said Joseph Jankowski, Case Western Reserve's associate vice president for technology management within the university's Technology Transfer Office.

Potential for improved treatment of Type 1 and Type 2 diabetes results from the work of Dr. Michael Weiss, chairman of the Biochemistry Department at Case Western Reserve University's School of Medicine. His approximately 20 years of research into the structure and function of biological molecules has focused on insulin, insulin analogs and insulin receptors.

New and improved insulin analogs will offer attractive alternatives for patients and may also revolutionize the use of insulin pumps. Jankowski said important characteristics of these insulin analogs are that they are faster acting with fewer side effects, have stability without refrigeration and are long acting with lower potential risk of cancer.

Thermalin Diabetes has closed more than $275,000 in seed financing from individual investors.

"We are very pleased to have the support of so many individuals in the Cleveland community," said Weiss, who is founder and chief scientific officer of Thermalin Diabetes. "While we have a long way to go, I am hopeful that together we can create a great biotech success for Cleveland."

Thermalin Diabetes also has received a $254,000 Phase I Small Business Technology Transfer Grant from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health. This grant is intended to support the development of one of Thermalin's insulin analogs through large animal testing. When the company achieves the grant's specific aims, it will be eligible for significant additional grant funding to advance the compound to human clinical trials.

Among the company's early backers is Dick Dietrich, co-founder of Integral Inc. and a long-time supporter of the Diabetes Association of Greater Cleveland and the Dietrich Diabetes Research Institute.

Weiss' scientific work with insulin has been enriched by a gifted group of students and fellows. Colleagues at CWRU are Qing-xin Hua, S. Nakagawa, Zhu-li Wan, Nelson Phillips, Faramarz Ismail-Beigi and Jonathan Whittaker, and long-term collaborators are Guy Dodson (University of York, UK), Panno Katsoyannis (Mt. Sinai School of Medicine, NY) and Don Steiner (University of Chicago).


'/>"/>

Contact: Marv Kropko
mrk107@case.edu
216-368-6890
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. University of Texas Southwestern Medical Center researcher wins Avanti Award in lipids
2. UT Southwestern receives $700,000 from HHMI to promote medical education of Ph.D. students
3. The impact of the diffusion of maize to the Southwestern United States
4. Happy holidays from the groaning board; Western diets turn on fat genes
5. UT Southwestern scientist begins to unravel what makes pandemic H1N1 tick
6. UT Southwestern receives $42 million in Recovery Act stimulus funding
7. UT Southwestern researchers use drug-radiation combo to eradicate lung cancer
8. UT Southwestern patient first in North Texas to receive newest-generation heart failure device
9. ICU patients on ventilators flex and stretch in study at Case Western Reserve University
10. Science wins fight over evolution in schools, says Case Western Reserve University author
11. Case Western Reserve University discovers Merkel cell originates from skin, not the neural crest
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
(Date:3/29/2016)... BOCA RATON, Florida , March 29, 2016 /PRNewswire/ ... ("LegacyXChange" or the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect ... Synthetic DNA in ink used in a variety of ... preventing theft. Buyers of originally created collectibles from athletes ... authenticity through forensic analysis of the DNA. ...
(Date:3/21/2016)... Massachusetts , March 22, 2016 ... facial recognition with passcodes for superior security   ... ), a leading provider of secure digital communications services, ... their biometric technology and offer enterprise customers, particularly those ... secure facial recognition and voice authentication within a mobile ...
Breaking Biology News(10 mins):
(Date:5/6/2016)... New York , May 6, 2016 ... Market Research " Molecular Diagnostic Market for Group A Streptococcus ... Analysis, Size, Share, Growth, Trends, and Forecast, 2015 - 2023 ... for group A streptococcus (GAS) nucleic acid (NA) test products ... is projected to expand at a CAGR of 11.6% from ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... definitive agreement to acquire Algynomics, a research-stage pain diagnostics company. The Algynomics ... individuals at increased risk for the development of chronic pain, which will allow ...
(Date:5/4/2016)... ... May 05, 2016 , ... CereScan, ... the National Stroke Association during National Stroke Awareness Month in May. An ... pages throughout the month. CereScan will donate $1 up to a maximum ...
(Date:5/4/2016)... New York, NY (PRWEB) , ... May 04, 2016 , ... ... neurofibromatosis (NF), a genetic disorder that causes tumors to grow on nerves throughout the ... treatment or cure. , Through numerous community events held during the month of May, ...
Breaking Biology Technology: