Navigation Links
Case Western Reserve University grants option to startup Thermalin Diabetes Inc.
Date:12/11/2009

CLEVELAND Case Western Reserve University has granted an 18-month, exclusive option to startup Thermalin Diabetes Inc. regarding a portfolio of insulin analogs. The company must reach certain milestones in order to exercise its option to obtain an exclusive license on therapies designed to help patients with diabetes.

Cleveland-based Thermalin Diabetes is developing treatments that it hopes will become an important part of the $12 billion, rapidly growing insulin market. Insulin is a therapeutic protein used to manage blood sugar levels. Innovations in the 1990s led to the introduction of insulin analogs with superior therapeutic performance.

"This is one of the coolest technologies that we've seen, because of the potential to serve mankind," said Joseph Jankowski, Case Western Reserve's associate vice president for technology management within the university's Technology Transfer Office.

Potential for improved treatment of Type 1 and Type 2 diabetes results from the work of Dr. Michael Weiss, chairman of the Biochemistry Department at Case Western Reserve University's School of Medicine. His approximately 20 years of research into the structure and function of biological molecules has focused on insulin, insulin analogs and insulin receptors.

New and improved insulin analogs will offer attractive alternatives for patients and may also revolutionize the use of insulin pumps. Jankowski said important characteristics of these insulin analogs are that they are faster acting with fewer side effects, have stability without refrigeration and are long acting with lower potential risk of cancer.

Thermalin Diabetes has closed more than $275,000 in seed financing from individual investors.

"We are very pleased to have the support of so many individuals in the Cleveland community," said Weiss, who is founder and chief scientific officer of Thermalin Diabetes. "While we have a long way to go, I am hopeful that together we can create a great biotech success for Cleveland."

Thermalin Diabetes also has received a $254,000 Phase I Small Business Technology Transfer Grant from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health. This grant is intended to support the development of one of Thermalin's insulin analogs through large animal testing. When the company achieves the grant's specific aims, it will be eligible for significant additional grant funding to advance the compound to human clinical trials.

Among the company's early backers is Dick Dietrich, co-founder of Integral Inc. and a long-time supporter of the Diabetes Association of Greater Cleveland and the Dietrich Diabetes Research Institute.

Weiss' scientific work with insulin has been enriched by a gifted group of students and fellows. Colleagues at CWRU are Qing-xin Hua, S. Nakagawa, Zhu-li Wan, Nelson Phillips, Faramarz Ismail-Beigi and Jonathan Whittaker, and long-term collaborators are Guy Dodson (University of York, UK), Panno Katsoyannis (Mt. Sinai School of Medicine, NY) and Don Steiner (University of Chicago).


'/>"/>

Contact: Marv Kropko
mrk107@case.edu
216-368-6890
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. University of Texas Southwestern Medical Center researcher wins Avanti Award in lipids
2. UT Southwestern receives $700,000 from HHMI to promote medical education of Ph.D. students
3. The impact of the diffusion of maize to the Southwestern United States
4. Happy holidays from the groaning board; Western diets turn on fat genes
5. UT Southwestern scientist begins to unravel what makes pandemic H1N1 tick
6. UT Southwestern receives $42 million in Recovery Act stimulus funding
7. UT Southwestern researchers use drug-radiation combo to eradicate lung cancer
8. UT Southwestern patient first in North Texas to receive newest-generation heart failure device
9. ICU patients on ventilators flex and stretch in study at Case Western Reserve University
10. Science wins fight over evolution in schools, says Case Western Reserve University author
11. Case Western Reserve University discovers Merkel cell originates from skin, not the neural crest
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
(Date:3/24/2017)... 24, 2017 Research and Markets has announced ... Analysis & Trends - Industry Forecast to 2025" report to ... The ... a CAGR of around 15.1% over the next decade to reach ... analyzes the market estimates and forecasts for all the given segments ...
(Date:3/23/2017)... 2017 Research and Markets has announced the ... Trends - Industry Forecast to 2025" report to their offering. ... The Global ... of around 8.8% over the next decade to reach approximately $14.21 ... market estimates and forecasts for all the given segments on global ...
Breaking Biology News(10 mins):
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... ... scaffold technology, today announced the election of Paul Hermes, Entrepreneur in Residence at ... , Biorez has developed a proprietary, tissue-engineered scaffold for anterior cruciate ligament ...
(Date:9/20/2017)... (PRWEB) , ... September 20, 2017 , ... ... pathology, and Huron Digital Pathology , a provider of whole slide imaging ... Pathology Visions conference . The workshop, entitled “Successfully Deploying a Best-in-Class Strategy for ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... the most dangerous step of sample prep for metals digestion—the addition of acids ... at an affordable price. The system is ideal for any laboratory performing their ...
(Date:9/19/2017)... Washington, D.C. (PRWEB) , ... September 19, 2017 ... ... care during an biological outbreak is about to be eliminated, said Lyle Probst, ... makes ExcitePCR’s FireflyDX™ technologies different than other pathogen detection solutions, Probst ...
Breaking Biology Technology: