Navigation Links
Carnegie's Donald Brown wins Lasker-Koshland Award
Date:9/10/2012

Baltimore, MDDirector Emeritus Donald Brown, of Carnegie's Department of Embryology, receives the prestigious 2012 Lasker-Koshland Special Achievement Award in Medical Science "For exceptional leadership and citizenship in biomedical scienceexemplified by fundamental discoveries concerning the nature of genes; and by selfless commitment to young scientists." Brown is honored along with Tom Maniatis of Columbia University.

Brown received his M.D. and M.S. in biochemistry from the University of Chicago Medical School in 1956. It was during medical school that he began to wonder how embryos develop. At the time, scientists had mapped out the process that produced anatomical features, but not the molecular underpinnings. Brown launched a bold, independent research program to study the details by looking at embryos that die particularly earlywhen new ribosomes, cellular protein factories, start accumulating. Brown, in collaboration with John Gurdon (Lasker Basic Medical Research Award, 2009), discerned that a structure called the nucleolus manufactures structural RNAs of the ribosome (ribosomal RNAs, or rRNAs).

Frog embryos do not make ribosomes during the first few days of development. Instead, they use the stockpile that the egg endowed to them. No one knew how a single cell could churn out so many protein-making factories. Brown and Igor Dawid (and, independently, Carnegie's Joseph Gall, Lasker Special Achievement Award, 2006) showed that frog eggs create extra rRNA genes. The researchers revealed the first example of gene amplification, a process that underlies other processes, including the runaway growth of drug-resistant cancer cells.

Brown used the amplified genes to isolate and study rRNA genes, which later resulted in studying genes via recombinant DNAa laboratory method that brings genetic material from various sources to produce sequences that are not found in nature. Brown used recombinant DNA to analyze an RNA called 5S RNA and he found a region in the middle of the gene that unexpectedly governs production of the gene's RNAthe first known "internal control region."

Today, Brown continues to study metamorphosis in frogs. Over the years he has made numerous fundamental discoveries concerning the nature of genes. He has also maintained a selfless commitment to young scientists by mentoring a generation of scientists at Carnegie and by founding and leading the Life Sciences Research Foundation (LSRF), a partnership that provides postdoctoral fellowships to some of the world's most promising researchers. LSRF boasts 450 current fellows and alumni, many of whom have gone on to successful academic careers.

Allan Spradling, current Embryology director remarked: "Don Brown excels in everything that truly matters in science. He opened new frontiers of knowledge using novel approaches that paved the way for many others. He champions the highest intellectual and ethical standards, regardless of current fashion. His personal mentorship and Life Sciences Research Foundation nurture young scientists. Finally, Brown's leadership as director is unmatched in the history of the Embryology Department."

Brown joined Carnegie in in 1961 as a fellow. He later became a staff member and then he became director of the department in 1976 where he built a world-renowned program. When Brown left the directorship in 1994 to become a staff member again, five of the eight laboratory heads were members of the U.S. National Academy of Sciences (NAS). Two of the remaining three would later join NAS and one would win the Nobel Prize.

Carnegie president Richard Meserve remarked: "Don Brown epitomizes Andrew Carnegie's original vision that by supporting exceptional individuals and letting them pursue their own research without constraints they will accomplish extraordinary science. The institution is proud of his scientific accomplishments and is grateful for his strong leadership, which has made the Department of Embryology a global success."


'/>"/>
Contact: Tina McDowell
tmcdowell@carnegiescience.edu
202-939-1120
Carnegie Institution
Source:Eurekalert  

Related biology news :

1. Are brown widows displacing black widow spiders around southern California homes?
2. Chemical fingerprinting tracks the travels of little brown bats
3. University of Illinois at Urbana-Champaign awarded 5-year grant from NASA
4. Studying sex differences in autism focus of $15 million NIH award to Yale center
5. State stem cell research funding agency awards $37.3 million to aid UC Irvine efforts
6. 2013 Rosalind Franklin Young Investigator Awards announced
7. Georgetown Lombardi researcher awarded Provocative Question grant from NCI
8. Science research led in Gulf of Mexico by Penn State biologist to be honored with US award
9. Jeff Crandall Honored With SAE International Arnold W. Siegel International Transportation Safety Award
10. 6 NARSAD Young Investigator Grants awarded to CAMH
11. 2012 Science in Society Journalism Awards announced
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Carnegie's Donald Brown wins Lasker-Koshland Award
(Date:2/3/2017)... 3, 2017 A new independent identity strategy ... LLP (IdSP) . Designed to fill a critical niche ... market, founding partners Mark Crego and ... just in identity expertise that span federal governments, the ... The Crego-Kephart combined expertise has a common theme born ...
(Date:1/31/2017)... 2017  Spero Therapeutics, LLC, a biopharmaceutical company ... of bacterial infections, today announced it has acquired ... Pro Bono Bio Ltd (PBB) to bolster its ... forms of Gram-negative bacteria.   The assets acquired have ... PBB group company. "The acquisition of ...
(Date:1/24/2017)... Jan. 24, 2017 Biopharm Reports has ... laboratory use of nuclear magnetic resonance spectroscopy (NMR). ... and profiled current practices, developments, trends and end-user ... as growth and opportunities. These areas include growth ... instruments, needs and innovation requirements, hyphenated NMR techniques, ...
Breaking Biology News(10 mins):
(Date:2/24/2017)... , Feb. 24, 2017 Provectus ... or the "Company"), a clinical-stage oncology and dermatology ... the deadline to participate in its previously announced ... consisting of shares of common stock and Series ... holders of listed warrants. As ...
(Date:2/24/2017)... 2017  Driven by consumers, preference towards more ... fastest growing categories, finds the recently published U.S. ... Care: Multi-regional Market Analysis and Opportunities study ... Kline. "Biotechnology actives are derived from ... effective for skin and hair care applications," explains ...
(Date:2/24/2017)... Biologic Products, Inc. (NASDAQ: CBPO) ("China Biologic" or the "Company"), ... announced its financial results for the fourth quarter and fiscal ... Highlights Total sales in the fourth ... increased by 13.6% in USD terms to $77.6 million from ... Gross profit increased by 13.3% to $46.8 million from ...
(Date:2/23/2017)... LONDON and NEW YORK ... at HIMSS, Lumeon , a leading digital ... (DN Telehealth), a provider of telemedicine and remote ... care pathways for telemedicine reimbursements.  ... and their patients, in real-time, extending consultations beyond ...
Breaking Biology Technology: