Navigation Links
Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
Date:8/22/2007

BOSTONCarnegie Mellon University chemists have solved a decade-long molecular mystery that could eventually help scientists develop drug therapies to treat a variety of disorders, including epilepsy and Alzheimers disease. Using intensive theoretical and computational calculations, Carnegie Mellon researchers have modeled the initial molecular changes that occur when the neurotransmitter glutamate docks with a receptor on a neuron, which sets in motion a chain of events that culminates in the neuron firing an electrical impulse.

Tatyana Mamonova, a postdoctoral fellow in Assistant Professor Maria Kurnikovas laboratory at Carnegie Mellon, will present this report Wednesday, Aug. 22 at the 234th national meeting of the American Chemical Society in Boston.

Glutamate receptors, which are proteins found in neurons, form a channel through the neurons membrane. When glutamate, a signaling molecule released by other neurons, docks with the glutamate receptor, it causes a series of molecular shape changes that eventually open the channel and excite the neuron. Although the structure of the glutamate receptors docking site was known, no one knew precisely which atomic interactions between glutamate and the receptor caused the receptor to change its conformation until now.

The docking site (or ligand binding domain) closes when glutamate binds to it. Tatyana found two key electrostatic interactions that lock the ligand-binding site in its closed form once the ligand is bound, said Kurnikova. With this knowledge in hand, we can now model binding-site closure and opening using a computer.

Being able to simulate this conformational change is critical to understanding how binding regulates the protein channel, Kurnikova added. Ultimately, we could use the computer model to design a drug that either inhibits or enhances the activity of the glutamate receptor. Typically, pharmaceutical companies may scan hundreds of potential drugs to find
'/>"/>

Contact: Amy Pavlak
apavlak@andrew.cmu.edu
412-268-8619
Carnegie Mellon University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
2. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert
3. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
4. Carnegie Mellon University research reveals how cells process large genes
5. Carnegie Mellon cyLab researchers work to develop new red tide monitoring
6. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
7. Carnegie Mellon scientists create PNA molecule with potential to build nanodevices
8. Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
9. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
10. Carnegie Mellon scientists show brain uses optimal code for sound
11. DNA conclusive yet still controversial, Carnegie Mellon professor says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... in locomotion. Swimming microorganisms, such as bacteria and spermatozoa, ... the viscous forces exerted by the surrounding fluid. ... scientists have found that the direction of propulsion made ... by a viscoelastic fluid. These findings have been published ... the Alternative Energies and Atomic Energy Commission (CEA), in ...
(Date:7/29/2014)... this fascinating journey to the edge of science, Clment ... book The Beginning and the End: Does our universe ... cyclic? Are we alone in the universe? What is ... evolution? Grounded in science and committed to philosophical rigor, ... of intelligent life is not an accident, but may ...
(Date:7/29/2014)... of a stroke is an immensely complex challenge ... as effective therapy. Advancing such knowledge to improve ... focus of research by Sergei Adamovich, associate professor ... faculty more than a decade ago. It is ... from sources such as the National Institutes of ...
Breaking Biology News(10 mins):Optimum inertial self-propulsion design for snowman-like nanorobot 2Book: 'The Beginning and the End' 2Continuing the quest for better stroke therapies 2Continuing the quest for better stroke therapies 3
... is a stream worth? Can we put a dollar ... to establish the economic value of "ecosystem services," the ... the beauty and utility of a wetland into pounds ... pulled out of urban wastewater, and inches of floodwater ...
... Chemicals in the environment that mimic estrogen can strongly ... research to be presented at the 2012 International Zebrafish ... Wisconsin, reveals that these substances may act even earlier ... embryonic development. Estrogenic compounds in the environment are ...
... 21, 2012A new study by researchers at St. Michael,s Hospital ... as previously thought and that it may even provide some ... connections made between fructose intake and rates of obesity," said ... this research suggests that the problem is likely one of ...
Cached Biology News:Risks and rewards of quantifying nature's 'ecosystem services' 2Environmental estrogens affect early developmental activity in zebrafish 2Environmental estrogens affect early developmental activity in zebrafish 3New evidence in fructose debate: Could it be healthy for us? 2
(Date:7/29/2014)... (PRWEB) July 29, 2014 The first ... a next generation approach to robotics. What sets Droidles ... patent pending technology that allows them to communicate, share ... wirelessly over the internet. , “The invention is the ... the little Droidles a life of their own, both ...
(Date:7/29/2014)... White papers by Clinovo ... eClinical technologies, have been published by leading pharmaceutical publications ... long line of white papers by Clinovo to have ... Leader, Pharmaceutical Online, and OpenHealthNews. , At the request ... CTO Marc Desgrousilliers, 'The Five Essentials of Cloud ...
(Date:7/28/2014)... 2014 Sapphire Energy, Inc. , a ... appointment of biotechnology veteran James Levine as ... Levine replaces Cynthia ,CJ, Warner, who is stepping down ... of the company,s board of directors. "The ... deliver commercial scale algae-based fuels has been tremendous, from ...
(Date:7/28/2014)... July 28, 2014 Proove Biosciences ... will be exhibiting data and research conducted through their ... Spine Intervention Society’s (ISIS) 22nd Annual Scientific Meeting. ... the Hyatt Regency, in Orlando, Florida. , ... clinical competence of physicians who care for patients suffering ...
Breaking Biology Technology:Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 3Sapphire Energy Announces New CEO James Levine 2Sapphire Energy Announces New CEO James Levine 3Proove Biosciences Exhibits Industry Leading Data and Research at International Spine Intervention Society’s 22nd Annual Scientific Meeting 2
... seventh in a series of articles on developing start-up companies ... focused on business taxes. , , Madison, ... ready to begin hiring workers. As discussed in the previous ... Social Security and Medicare taxes, and ...
... has added so much complexity to information technology systems ... ,That according to John Swainson, president and CEO of ... address at the 2007 Fusion CEO-CIO Symposium . ... relationship between business and information technology. , ,That relationship ...
... day. So several speakers at the Fusion 2007 CEO-CIO Symposium ... that "work smarter, not harder" is more than just an ... Wisconsin-Madison School of Business, summed it up: "When productivity grows, ... producing more by working more hours and giving up leisure ...
Cached Biology Technology:Early Stage 7, Part I: Just what is an employee? 2Early Stage 7, Part I: Just what is an employee? 3Early Stage 7, Part I: Just what is an employee? 4Early Stage 7, Part I: Just what is an employee? 5Fusion 2007: CA chief says IT complexity raises risk 2Fusion 2007: CA chief says IT complexity raises risk 3Fusion 2007: Innovation drives productivity in post 24x7 world 2
... Microarrays designed for RNA aptamer screening and ... and powerful Paraflo microfluidic on-chip synthesis platform. ... our comprehensive DNA/RNA Aptamer Microarray Service. ... RNA Aptamer Microarray contains greater than 1500 ...
... designed for RNA aptamer screening and binding ... powerful Paraflo microfluidic on-chip synthesis platform. Thousands ... synthesized on-chip and LC Sciences can provide ... are available as part of our comprehensive ...
... is commonly used as a fusion partner ... The GSTTag sequence has been reported to ... the solubility of its fusion partners. When ... GSTTag fusion proteins can be purified with ...
... peptide whose sequence is from the C-terminal end of the mouse retinoic ... amino acids 429 to 448 of RAR*. The sequence of PEP-005 ... - S - P - S - S - V - E ... - S - P - L - L - Q (The ...
Biology Products: