Navigation Links
Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
Date:8/22/2007

BOSTONCarnegie Mellon University chemists have solved a decade-long molecular mystery that could eventually help scientists develop drug therapies to treat a variety of disorders, including epilepsy and Alzheimers disease. Using intensive theoretical and computational calculations, Carnegie Mellon researchers have modeled the initial molecular changes that occur when the neurotransmitter glutamate docks with a receptor on a neuron, which sets in motion a chain of events that culminates in the neuron firing an electrical impulse.

Tatyana Mamonova, a postdoctoral fellow in Assistant Professor Maria Kurnikovas laboratory at Carnegie Mellon, will present this report Wednesday, Aug. 22 at the 234th national meeting of the American Chemical Society in Boston.

Glutamate receptors, which are proteins found in neurons, form a channel through the neurons membrane. When glutamate, a signaling molecule released by other neurons, docks with the glutamate receptor, it causes a series of molecular shape changes that eventually open the channel and excite the neuron. Although the structure of the glutamate receptors docking site was known, no one knew precisely which atomic interactions between glutamate and the receptor caused the receptor to change its conformation until now.

The docking site (or ligand binding domain) closes when glutamate binds to it. Tatyana found two key electrostatic interactions that lock the ligand-binding site in its closed form once the ligand is bound, said Kurnikova. With this knowledge in hand, we can now model binding-site closure and opening using a computer.

Being able to simulate this conformational change is critical to understanding how binding regulates the protein channel, Kurnikova added. Ultimately, we could use the computer model to design a drug that either inhibits or enhances the activity of the glutamate receptor. Typically, pharmaceutical companies may scan hundreds of potential drugs to find
'/>"/>

Contact: Amy Pavlak
apavlak@andrew.cmu.edu
412-268-8619
Carnegie Mellon University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
2. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert
3. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
4. Carnegie Mellon University research reveals how cells process large genes
5. Carnegie Mellon cyLab researchers work to develop new red tide monitoring
6. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
7. Carnegie Mellon scientists create PNA molecule with potential to build nanodevices
8. Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
9. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
10. Carnegie Mellon scientists show brain uses optimal code for sound
11. DNA conclusive yet still controversial, Carnegie Mellon professor says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... TORONTO , March 26, 2015 ... premier family, social, recreation and athletic club, today announced ... designed to allow freedom of movement for members and ... "Following a comprehensive process, we selected FST,s IMID ... sophistication and convenience for our members and staff, in ...
(Date:3/24/2015)... March 24, 2015   Crossmatch ™, a ... announced that its U.are.U ® 4500 Fingerprint ... Goorin Bros . to achieve PCI compliance for ... access to the POS terminal, protecting the retailer ... data breaches. With one-third of ...
(Date:3/23/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market, announces its biometric payment technology, the Wocket® ... television starting March 30 th . ... New York markets. ... about our new ad campaign following the recent initial shipment ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3
... 2013The repair of ruptured tendons often requires the use of ... bone. A tissue-engineered collagen graft can reduce the complications associated ... be able to support full load bearing until integrated into ... this tissue-engineered tendon is described in BioResearch Open Access ...
... agent for Alzheimer,s disease, and its derivative, ... neuroprotective effect against Alzheimer,s disease-relevant insults. Al-though ... S14G-humanin exerts its effects remains unclear. A ... from Henan Provincial People,s Hospital, China investigated ...
... vegetation follows the change of the seasons. After a winter ... now brought a new correlation to light: The colder the ... warmer winters can be expected as the climate changes, the ... and later giving an advantage to shrubs and invasive ...
Cached Biology News:Novel technique for suturing tissue-engineered collagen graft improves tendon repair 2Warm winters let trees sleep longer 2
(Date:4/21/2015)... RESEARCH TRIANGLE PARK, N.C. , April 21, ... ) announced today that it will release its first ... April 28, 2015. United Therapeutics will host ... 9:00 a.m. Eastern Time.  The teleconference is accessible by ... of the teleconference will be available for one week ...
(Date:4/21/2015)... 2015 YourEncore, an Indianapolis, Indiana-based ... consumer products and food sciences industries solve complex ... for Clinical Research Excellence and Safety (ACRES), a ... clinical research, have partnered to speed innovation in ... YourEncore brings to ACRES experts with proven experience, ...
(Date:4/20/2015)... FREMONT, Calif. , April 20, 2015 /PRNewswire/ ... biopharmaceutical company focused on cardio-renal, gastrointestinal and metabolic ... MBBS, MRCP, has joined the Company,s Board of ... management and board level experience, having built and ... clinical development, regulatory approval and into healthcare systems ...
(Date:4/20/2015)... 20, 2015 /CNW/ - Portage Biotech Inc. ("Portage" or ... is pleased to announce that its wholly owned subsidiary, ... study that showed one of its proprietary human-derived CPP ... tissue through inhibition of NFkB signalling even if administered ... permeability of the blood brain barrier (BBB) in mice ...
Breaking Biology Technology:YourEncore and ACRES Partner to Drive Innovation in Clinical Research 2YourEncore and ACRES Partner to Drive Innovation in Clinical Research 3Ardelyx Appoints Dr. Annalisa Jenkins to Its Board of Directors 2Ardelyx Appoints Dr. Annalisa Jenkins to Its Board of Directors 3Ardelyx Appoints Dr. Annalisa Jenkins to Its Board of Directors 4Portage's CPP Platform Delivers a Peptide Cargo Across Blood Brain Barrier 2Portage's CPP Platform Delivers a Peptide Cargo Across Blood Brain Barrier 3
... deal from January through March this year, according to the ... state said that the lack of deals in a quarter ... another reminder that capital is hard to come by. , ... sometimes adding up to around $20 million or $25 million, ...
... a California life-science firm, announced on Monday afternoon that ... in Madison, over a patent issue. Third Wave sued ... technologies involved are some of Third Wave's Invader products ... said in a release that FullVelocity allows researchers to ...
... computer just isn't enough. Researchers at the University of ... groups of tightly networked computers that share tasks such ... Smith and David Schwartz are working with the ... tasks manageable. The system used is Condor, software developed ...
Cached Biology Technology:Money Tree survey shows lull in Wisconsin venture capital deals 2Money Tree survey shows lull in Wisconsin venture capital deals 3
... The Fujifilm Life Science FLA-7000 excels at ... CBB-stained gel documentation. It features four easy-to-access ... and a filter for Imaging Plates) for ... a customizable choice of four kinds of ...
... Software has been optimized for the analysis ... the software to quickly and accurately locate ... of an ELISA plate or each section ... has been customized to incorporate standard ELISA ...
For microscopy...
... in the base hold 10 l of ... hydration around the edges of the coverslip. ... waterbath contamination. This chamber can be used ... ovens. Linkage: This CLS number is a ...
Biology Products: