Navigation Links
Carnegie Mellon scientists discover how molecular motors go into 'energy save mode'
Date:8/11/2011

nesin folds in upon itself to prevent ATP from being squandered. Although scientists knew that one tail binds to the two heads to keep it in a folded "autoinhibited" state, the molecular mechanism remains unclear. Several possibilities have been proposed, but these latest findings suggest only one solution.

Hackney worked with Hung Yi Kristal Kaan and Frank Kozielski at the Beatson Institute for Cancer Research in Glasgow, Scotland, who crystallized a key portion of the kinesin molecule a tail that was bound to the heads. The crystal structure confirmed that the complex contained two head domains and only one tail domain. Hackney then carried out biochemical manipulations to determine precisely how the tail interacts with the heads, which turned out to be what the authors refer to as a "double lockdown."

"It was actually a big surprise," Hackney said, "because it ruled out all of the obvious things that had been proposed for how the tail domain autoinhibits the motor domain. It does not cause a conformational change, and it does not block the surfaces that interact with ATP or the microtubular track."

Kinesin's heads are typically joined together at one spot, called the hinge. In the new structure, the heads swing in toward each other and are bridged by the tail domain, effectively cross-linking the heads at the site of tail binding. This double lockdown at the hinge and at the bridge prevents the heads from separating. Because the heads need to be separate from each other to break down ATP, the double lockdown effectively stops the molecule from generating fuel to power the motor.

The researchers suggest that other kinesins may be regulated by the same autoinhibitory mechanism. Humans have dozens of different kinesin motors that transport a variety of cargo, including proteins associated with Alzheimer's, Huntington's and Parkinson's diseases. Kinesins are also involved in separating chromosomes during cell division, making t
'/>"/>

Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-268-9982
Carnegie Mellon University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Carnegie Mellons Matyjaszewski to receive Wolf Prize in Chemistry
2. Carnegie Mellon researchers identify Facebook neurons
3. Carnegie Mellon researchers discover mechanism for signaling receptor recycling
4. Carnegie Mellon receives funding to create new program studying environmental impact of nanotechnology
5. Carnegie Mellon hosting first conference to explore scientific use of gigapixel imagery
6. Neuronal diversity makes a difference, says Carnegie Mellon study
7. Carnegie Mellon researchers turn up brightness on fluorescent probes
8. Carnegie Mellons Yoed Rabin receives grants
9. Carnegie Mellon researchers create fluorescent biosensor to aid in drug development
10. Carnegies Doug Koshland elected to National Academy of Sciences
11. Carnegies Chris Field elected to American Academy of Arts & Sciences
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Carnegie Mellon scientists discover how molecular motors go into 'energy save mode'
(Date:8/27/2014)... listen carefully to someone, the first thing we do ... stop moving altogether. This strategy helps us hear better ... , This interplay between movement and hearing also has ... has long suggested that the brain,s motor cortex, which ... rise to our conscious perception of sound. , A ...
(Date:8/27/2014)... often depicted as giant, frightening beasts. But every creature ... a rock slab containing fossils of 24 very young ... group of hatchlings overseen by a caretaker, according to ... Penn,s Brandon P. Hedrick and Peter Dodson led the ... Natural History, where the specimen is held. Hedrick is ...
(Date:8/27/2014)... the long-standing belief that a deficiency in serotonin ... central role in depression. In the journal ACS ... ability to make serotonin in their brains (and thus ... show depression-like symptoms. , Donald Kuhn and colleagues ... Wayne State University School of Medicine note that depression ...
Breaking Biology News(10 mins):Stop and listen: Study shows how movement affects hearing 2Stop and listen: Study shows how movement affects hearing 3Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 2Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 3New study throws into question long-held belief about depression 2
... National Institutes of Health (NIH) announced today a new ... articles resulting from NIH-funded research. The policy ?the first ... release to the public manuscripts from research supported by ... of final publication. , These peer-reviewed, NIH-funded research publications ...
... Medical School, demonstrating how malaria parasites form mutations that ... the key to a new treatments for a disease ... , The scientists developed disease models using yeast and ... the anti-malarial drug, atovaquone. The study, featured as the ...
... for humans and most animals but not Australia's green-striped ... University of Queensland has found that unlike most animals, ... the green-striped burrowing frog is able to absorb nutrients ... than frogs that had eaten regularly. , "They can ...
Cached Biology News:NIH Calls on Scientists to Speed Public Release of Research Publications 2NIH Calls on Scientists to Speed Public Release of Research Publications 3Molecular models advance the fight against malaria 2A frog's life is food for thought 2A frog's life is food for thought 3
(Date:8/27/2014)... survive impact by the huge amounts of energy ... energy for photosynthesis. The hypothesis is that the ... the energy throughout the entire protein molecule through ... now managed to successfully ,film, this process. , ... which play a role in photosynthesis and thus ...
(Date:8/27/2014)... ANGELES , Aug. 27, 2014  Lisa Kulik ... years this July 4 holiday, thanks to a groundbreaking ... Ph.D., an internationally renowned clinician-researcher at the University of ... a 55-year-old Peoria, Ariz. resident ... robs its victims of sight. On June 2, she ...
(Date:8/27/2014)... -- Reportbuyer.com has added a new market research ... Rational View https://www.reportbuyer.com/product/1595336/The-Graphene-Opportunity---A-Rational-View.html ... similar amount of hype currently surrounds graphene, with ... water treatment, but is graphene the only solution? ... Opportunity Report, authored by Tim Harper ...
(Date:8/27/2014)... -- ARCH Venture Partners, one of the largest U.S. ... seed and early-stage advanced technology companies, today announced ... than $400 million in subscriptions. ARCH Venture Fund ... more than $150 million. "The enthusiasm ... of our approach to finding and funding new ...
Breaking Biology Technology:DTU researchers film protein quake for the first time 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 3USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 5The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4Latest ARCH Venture Partners Fund Closes Above $400 Million 2Latest ARCH Venture Partners Fund Closes Above $400 Million 3
... been proposed for regenerative medicine and tissue replacement after ... to efficiently develop into the desired specific cell type ... neurons now limits the potential clinical utility of ... within aggregates of embryonic stem cells via biodegradable microspheres ...
... Ill., April 9 Baxter Healthcare Corporation,today ... VitalShield,protective coating, the first needleless intravenous (IV) ... available for hospitals in the,United States and ... to kill on,average 99.9 percent or more ...
... April 9 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc.,("Oncolytics") ... its U.K. combination REOLYSIN(R) and carboplatin/paclitaxel,trial. Dr. ... Research, London,and the principal investigator for the ... Annual Conference of the British Society for ...
Cached Biology Technology:Method to deliver molecules within embryonic stem cells improves differentiation 2Method to deliver molecules within embryonic stem cells improves differentiation 3Baxter's V-Link Luer-Activated Device With VitalShield Protective Coating Now Available For Hospitals 2Baxter's V-Link Luer-Activated Device With VitalShield Protective Coating Now Available For Hospitals 3Baxter's V-Link Luer-Activated Device With VitalShield Protective Coating Now Available For Hospitals 4Oncolytics Biotech Inc. Reports Positive Interim Results of U.K. Combination REOLYSIN(R) and Carboplatin/Paclitaxel Trial 2Oncolytics Biotech Inc. Reports Positive Interim Results of U.K. Combination REOLYSIN(R) and Carboplatin/Paclitaxel Trial 3
Human Carnosine Dipeptidase 1 Affinity Purified PAb...
Rabbit polyclonal to Syntrophin alpha 1 ( Abpromise for all tested applications). entrezGeneID: 6640 SwissProtID: Q13424...
Mouse monoclonal [Flt-1/EWC] to VEGF Receptor 1 ( Abpromise for all tested applications). entrezGeneID: 2321 SwissProtID: P17948...
Mouse monoclonal [4i97] to HLA Class 1 A25 ( Abpromise for all tested applications). Antigen: Full length protein (Human): HLA Class 1 Antigen-A25. Swiss Protein ID: P18462...
Biology Products: