Navigation Links
Carnegie Mellon scientists discover how molecular motors go into 'energy save mode'
Date:8/11/2011

PITTSBURGHThe transport system inside living cells is a well-oiled machine with tiny protein motors hauling chromosomes, neurotransmitters and other vital cargo around the cell. These molecular motors are responsible for a variety of critical transport jobs, but they are not always on the go. They can put themselves into "energy save mode" to conserve cellular fuel and, as a consequence, control what gets moved around the cell, and when.

A new study from Carnegie Mellon University and the Beatson Institute for Cancer Research published in the Aug. 12 issue of Science describes how the motors fold in on themselves, or save energy, when their transport services aren't required. According to the researchers, the solution to this molecular puzzle provides new insight into how molecular motor proteins are regulated, and may open new avenues for the treatment of various neurodegenerative diseases, such as Alzheimer's and Huntington's.

"Molecular motor proteins play a major role in all eukaryotic cells, but they are particularly critical to nerve cells," said David Hackney, professor of biological sciences in the Mellon College of Science, and one of the paper's authors. "Nerve cells have this special problem where proteins, such as receptors for neurotransmitters, get synthesized in the cell body and have to be shipped all the way down the axon. Problems in this transport system may play a role in a number of neurological conditions."

Hackney focuses his research on kinesin-1, the principle motor protein that moves cargo from the nerve cell body down the axon. A typical kinesin molecule has two tails on one end that attach to the cargo and two globular heads on the other end that crank along fibers inside the cell called microtubules, pulling the cargo forward. The movement of the heads, or motor domains, is fueled by the breakdown of ATP, a molecule that stores the energy that drives cellular work. When cargo isn't attached, ki
'/>"/>

Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-268-9982
Carnegie Mellon University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Carnegie Mellons Matyjaszewski to receive Wolf Prize in Chemistry
2. Carnegie Mellon researchers identify Facebook neurons
3. Carnegie Mellon researchers discover mechanism for signaling receptor recycling
4. Carnegie Mellon receives funding to create new program studying environmental impact of nanotechnology
5. Carnegie Mellon hosting first conference to explore scientific use of gigapixel imagery
6. Neuronal diversity makes a difference, says Carnegie Mellon study
7. Carnegie Mellon researchers turn up brightness on fluorescent probes
8. Carnegie Mellons Yoed Rabin receives grants
9. Carnegie Mellon researchers create fluorescent biosensor to aid in drug development
10. Carnegies Doug Koshland elected to National Academy of Sciences
11. Carnegies Chris Field elected to American Academy of Arts & Sciences
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Carnegie Mellon scientists discover how molecular motors go into 'energy save mode'
(Date:3/20/2015)... Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has announced the addition ... report to their offering. This report analyzes ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... . Annual estimates and forecasts are provided for ...
(Date:3/18/2015)... SPRINGS, Florida , March 18, 2015 ... well as businesses, new revolutionary smart wallets and apps continue ... pace.  Companies currently entrenched in the mobile payment industry in ... Alibaba Group Holding Ltd. (NYSE: BABA ), Apple ... GOOG ) and Facebook Inc. (NASDAQ: FB ...
(Date:3/17/2015)... , March 17, 2015 Emotient, ... analytics software, today announced general availability of ... service for the analysis of facial expressions. The ... advertising, media content, products and services. It delivers ... engagement and sentiment - as derived from facial ...
Breaking Biology News(10 mins):Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4
... between a wasp species and a newly discovered ... on how bacteria can be successfully utilized by ... In the new work, researchers show that a ... bacteria in unique structures within its antennae and ...
... a special protein found only in germ-line cells results ... a new study from researchers at the University of ... Human Reproduction in Penn's Center for Research in Reproduction ... point the way to a new type of contraceptive ...
... indoctrinated into believing that our senses, thoughts, feelings ... of brain cells, or neurons, each responsible for ... Either neurons release a neurotransmitter that excites a ... enhancing brain activity, or they dispatch a signal ...
Cached Biology News:Symbiotic bacteria protect hunting wasps from fungal infestation 2Of mice and men's (and women's) contraceptives 2Researchers make surprise discovery that some neurons can transmit three signals at once 2Researchers make surprise discovery that some neurons can transmit three signals at once 3
(Date:3/31/2015)... MONMOUTH JUNCTION, N.J., March 31, 2015 ... immunotherapy company using blood purification to treat critically-ill ... provides an operational summary and reports financial results ... 2014 CytoSorb® product revenues were ... 281%, compared to 2013 CytoSorb® revenues of $0.8M ...
(Date:3/31/2015)... 2015 Materials in Society Lecture ... June 30 2015   Elsevier , a ... services and publishing home of Materials Today , announced ... Materials in Society  Lecture Series . ... th International Conference on Materials for Advanced Technologies (ICMAT) ...
(Date:3/31/2015)... March 31, 2015   Mapi expands ... Medical Affairs and global Risk Management strength with ... previously announced acquisition . ... by a global team that includes physicians, pharmacists, ... of experience in navigating complex safety requirements throughout ...
(Date:3/31/2015)... This June 13th, a distinguished group of ... International Medical Schools will come together in Santa Monica, ... of stem cell therapy in treatments and cures for ... by the Ocular Research Symposia Foundation, Inc. ... meetings of top experts in the field of eye ...
Breaking Biology Technology:CytoSorbents Reports Record 2014 Revenue 2CytoSorbents Reports Record 2014 Revenue 3CytoSorbents Reports Record 2014 Revenue 4CytoSorbents Reports Record 2014 Revenue 5CytoSorbents Reports Record 2014 Revenue 6CytoSorbents Reports Record 2014 Revenue 7CytoSorbents Reports Record 2014 Revenue 8CytoSorbents Reports Record 2014 Revenue 9CytoSorbents Reports Record 2014 Revenue 10CytoSorbents Reports Record 2014 Revenue 11Elsevier Materials Science Council Introduces the Materials in Society Lecture Series at the International Conference on Materials for Advanced Technologies (ICMAT) 2Elsevier Materials Science Council Introduces the Materials in Society Lecture Series at the International Conference on Materials for Advanced Technologies (ICMAT) 3Mapi expands Pharmacovigilance and Risk Management capabilities 2Mapi expands Pharmacovigilance and Risk Management capabilities 3Sight Restoration Through Stem Cell Therapy - Subject of June Symposium of Experts 2
... carbon nanotubes more than doubles the growth rate of ... everything from lifesaving medications to sweeteners to dyes and ... to show that carbon nanotubes boost plant cell division ... . Mariya V. Khodakovskaya and colleagues explain that ...
... Ga., April 4, 2012  MiMedx Group, Inc. (OTCBB: MDXG), ... regenerative biomaterials and bioimplants processed from human amniotic membrane, ... revenue goal for the first quarter of 2012. The ... $3.6 million. The Company also reported ...
... SETAUKET, N.Y., April 4, 2012 Lixte Biotechnology Holdings, ... the United States Patent and Trademark Office for its ... homologs. Dr. John Kovach, founder and president ... certain types of skin lymphomas and many other HDACi ...
Cached Biology Technology:MiMedx Exceeds Revenue Goal for First Quarter of 2012 2Lixte Biotechnology Receives US Patent for Its Proprietary Histone Deacetylase Inhibitor 2Lixte Biotechnology Receives US Patent for Its Proprietary Histone Deacetylase Inhibitor 3
... dye terminators, template DNA, primers, salts or ... products have proved critical for both standard ... to work with dye terminator cycle sequencing ... The unique uniformity of the magnetic paeticles ...
Enodgenous alkaline phosphotase inhibitor. Levamisole solution is supplied in concentrated form (20x). The final concentration of levamisole in the substrate solution will be 1 mM....
uncoupling protein 2 (mitochondrial, proton carrier), mRNA (cDNA clone MGC:19567 IMAGE:4335185), complete cds...
Catch and Release® v2.0 Reversible Immunoprecipitation System...
Biology Products: