Navigation Links
Carnegie Mellon researchers use NMR to determine whether gold nanoparticles exhibit 'handedness'
Date:12/8/2011

ity, the crystal structures of only three nanoparticles have been reported."

In Jin's case, x-ray crystallography revealed that the gold nanoparticle is chiral. Chemists typically probe the internal chiral structure of gold nanoparticles using a technique called circular dichoism spectroscopy. When pure chiral molecules are exposed to circularly polarized light, each isomer absorbs the light differently, resulting in a unique and of opposite sign spectrum for each isomer. The process of creating the gold nanoparticles, however, often results in a 50/50 mix of each isomer, known as racemates.

"Because the spectrum is of opposite sign for each isomer, they cancel each other out and the net optical response is zero. This makes circular dichoism (CD) spectroscopy useless when it comes to determining the chirality of gold nanoparticles in 50/50 mixtures," said Gil, associate research professor of chemistry and director of the Department of Chemistry's NMR Facility.

Since Jin couldn't use circular dichoism spectroscopy, Gil was able to use NMR to help Jin distinguish between his gold nanoparticles' left- and right-handed isomers.

NMR spectroscopy takes advantage of the physical phenomenon wherein some nuclei wobble and spin like tops, emitting and absorbing a radio frequency signal in a magnetic field. By observing the behavior of these spinning nuclei, scientists can piece together the chemical structure of the compound.

In 1957, scientists observed that the hydrogen atoms of a freely rotating methylene (CH2) group produced two different frequencies if they were close to a chiral center. Jin's gold nanoparticles, which have a chiral core, are cushioned by several chemical groups, including freely rotating methylene groups. Gil reasoned that the nanoparticles' chiral core should induce the methylene group's two hydrogen atoms to give off different frequencies, a phenomenon known as diastereotopicity.

Gil and Jin comp
'/>"/>

Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-268-9982
Carnegie Mellon University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Carnegie Mellon to receive $900,000 from EPA for brownfields research
2. Carnegie Mellons Philip LeDuc participates in think tank forums
3. Carnegie Mellon developing automated systems to enable precision farming of apples, oranges
4. Carnegies Field and Koshland Elected AAAS Fellows
5. Carnegie Mellon to unveil new sequestration plan
6. Carnegies Arthur Grossman receives Gilbert Morgan Smith medal
7. Carnegies Joe Berry elected Fellow of the American Geophysical Union
8. Carnegies Doug Koshland elected Fellow of the American Academy of Microbiology
9. Carnegies Donald Brown receives lifetime achievement award from Society for Developmental Biology
10. Carnegie Mellon researchers apply new statistical test
11. Carnegie Mellons Kris Matyjaszewski recieves EPAs Presidential Green Chemistry Challenge Award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Carnegie Mellon researchers use NMR to determine whether gold nanoparticles exhibit 'handedness'
(Date:8/21/2014)... finding that has implications for life in other extreme ... solar system, LSU Associate Professor of Biological Sciences Brent ... Foundation, or NSF, this week published a paper confirming ... lies 800 meters (2600 feet) beneath the surface of ... Given that more than 400 subglacial lakes and numerous ...
(Date:8/21/2014)... Saturday to Wednesday, Oct. 18-22, 2014 , ... Harbor Drive, San Diego, CA 92101 , ... other presentations of the latest research in human ... session featuring high-scoring abstracts on rare genetic variants ... cancers, and treatment for sun sensitivity (Saturday, Oct. ...
(Date:8/21/2014)... of researchers at Louisiana Tech University has ... consumer-grade 3D printers and materials to fabricate ... and chemotherapeutic compounds for targeted drug delivery. ... and research faculty from Louisiana Tech,s biomedical ... create filament extruders that can make medical-quality ...
Breaking Biology News(10 mins):800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 4American Society of Human Genetics 2014 Annual Meeting 2Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3
... The notion of transplanting adult stem cells to treat or ... toward becoming a reality. In a study published today ... have demonstrated, for the first time, the ability to create ... the eye cells that die and cause loss of sight. ...
... Conservation Society and the State Institute of Animal Health (IAGRO) ... the first health assessments of white-lipped peccaries (medium-sized pig-like animals) ... the impact of Leptospirosis a zoonotic bacteria that affects ... and livestock. The studyconducted between 2003 and 2005 ...
... Exposure to alcohol in the womb doesn,t affect all fetuses ... give birth to a child with physical, behavioral or learning ... another woman who also drinks has a child without these ... by the mother to her son, according to new Northwestern ...
Cached Biology News:Stem cell therapy for age-related macular degeneration -- a step closer to reality 2Monitoring peccaries in Brazil benefits wildlife, local communities and food security 2Monitoring peccaries in Brazil benefits wildlife, local communities and food security 3Why some children are harmed by mother's alcohol, but others aren't 2
(Date:8/22/2014)... Research and Markets has announced the addition ... Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - ... The global molecular biology enzymes market was ... to grow at a CAGR of 13.74% to reach ... reagents find applications in a large number of fields ...
(Date:8/21/2014)... Aug. 21, 2014  BioSpecifics Technologies Corp. (NASDAQ: ... first in class collagenase-based products marketed as XIAFLEX ... the U.S. and XIAPEX ® in the ... a randomized, double-blind Phase 2a study of CCH ... fibrosclerotic panniculopathy. The results showed that all three ...
(Date:8/21/2014)... , August 21, 2014 ... ) has announced the addition of the  ... to their offering.       (Logo: ... hormone therapy, is a means of replacing ... by the body. This type of therapy ...
(Date:8/21/2014)... , Aug. 21, 2014 Mathematic studies at the ... University , and funded by the Jeffrey Epstein VI ... tumors can be visually identified for elimination. These aggressive cells ... study, which shows a topological map of what to look ... cancer research, for while tumor cells can be extracted from ...
Breaking Biology Technology:Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2
... developer to describe a Web site, youre likely to learn about ... youre likely to learn a lot about pinball. , ,A pinball ... works not the mechanical side of working that involves ASP, ... attracts and retains customers. By thinking of the Internet as a ...
... putting their state into further debt to fund ... California voters approved Proposition 71, which will provide ... decade. , ,The proposition, which was endorsed by ... California Institute for Regenerative Medicine. The institute will ...
... labs at the research park. An investment of $8.5 ... niche-market biotech company to Wisconsin, where it will inhabit brand-new ... ,The company is targeting a type of debilitating genetic disease ... new technique. , , Symbiontics, Inc. , which drew about ...
Cached Biology Technology:My 50 cents: Web sites and pinball machines 2My 50 cents: Web sites and pinball machines 3My 50 cents: Web sites and pinball machines 4Californians: Stem cells important enough to go into debt for 2Wisconsin VCs draw Missouri biotech firm to state 2Wisconsin VCs draw Missouri biotech firm to state 3Wisconsin VCs draw Missouri biotech firm to state 4
1000X solution used for inducing CopyControl™ based vectors to high copy numbers...
Donor feline serum and plasma...
Request Info...
8 different frozen tissues are mounted on positively charged glass slides...
Biology Products: