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Carnegie Mellon researchers to develop probes to study cellular GPS
Date:11/10/2009

neuron should go."

Bruchez and colleagues, which include Fred Wouters from the Goettingen Medical School and Christine Holt from the University of Cambridge, believe that the growth cone makes decisions through a combination of integrated molecular cues. However, since the growth cone is so small and only contains a small fraction of the nerve cell's content, it has been difficult to study the molecular processes at play in neuronal navigation. Traditionally to see such processes, researchers would load the growth cone with dyes that would make the cellular actions visible under a microscope, but introducing large amounts of dye to this limited cellular environment would disturb cellular function.

Through the HFSP-supported project Bruchez and colleagues will attempt to develop a sensitive set of probes that will report on the molecular activities at the growth cone including protein synthesis, protein degradation and protein folding. If successful, the probes could yield vital information about how the nervous system develops and repairs.


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Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-268-9982
Carnegie Mellon University
Source:Eurekalert

Page: 1 2

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