Navigation Links
Carnegie Mellon researchers to develop new drug delivery system
Date:11/2/2007

PITTSBURGH Carnegie Mellon Universitys Stefan F. Zappe is using adult neural stem cells to develop a new stem cell-based drug delivery therapy that may ultimately help treat a variety of inherited genetic disorders like Hunter syndrome.

Zappe, an assistant professor of biomedical engineering at Carnegie Mellon, and his graduate student Sasha Bakhru, are creating genetically engineered adult neural stem cells for delivery to patients brains, where they will be programmed to produce an essential missing protein. In Hunter syndrome, for example, patients are lacking the enzyme iduronate-2-sulfatase that helps cells break down certain waste products. One in every 130,000 boys is born with the rare but deadly genetic disorder.

Zappe, who is working with Dr. Raymond Sekula, a neurosurgeon at Allegheny General Hospital, said he selected adult neural stem cells for his work because they can be harvested from a patients brain, have the potential to be multiplied outside of the body, can be genetically engineered, can disperse within the brain once re-implanted and can replace all major cell types of the brain.

To support their therapeutic goals, Zappe and his team have developed cell-instructive microcapsules that contain neural stem cells. These microcapsules efficiently control whether stem cells proliferate (multiply), differentiate into more specialized cell types like neurons and to what extent implanted stem cells will be allowed to migrate to the host tissue.

Zappe will be using these caviar-sized capsules specifically for rapid manipulation of stem cells outside the body and for reliable delivery of stem cells to the brain. The acute inflammatory response that usually occurs from implantation would normally cause implanted neural stem cells to differentiate into mature cell types that are not able to migrate extensively. Encapsulated stem cells will be protected fr
'/>"/>

Contact: Chriss Swaney
swaney@andrew.cmu.edu
412-268-5776
Carnegie Mellon University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
2. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert
3. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
4. Carnegie Mellon University research reveals how cells process large genes
5. Carnegie Mellon cyLab researchers work to develop new red tide monitoring
6. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
7. Carnegie Mellon scientists create PNA molecule with potential to build nanodevices
8. Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
9. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
10. Carnegie Mellon scientists show brain uses optimal code for sound
11. DNA conclusive yet still controversial, Carnegie Mellon professor says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... is a key region in the global oceanic circulation. "On ... warm Atlantic water flows to the north into the Arctic ... and sea ice push their way out of the Arctic ... water cools here on its way to the north and ... in this manner drives the global band of oceanic currents ...
(Date:8/21/2014)... La. A team of researchers at ... method for using affordable, consumer-grade 3D printers ... that can contain antibacterial and chemotherapeutic compounds ... comprised of doctoral students and research faculty ... engineering programs collaborated to create filament extruders ...
(Date:8/20/2014)... In a study of 158 pregnant teenagers in ... craving and intentional consumption of ice, cornstarch, vacuum dust, ... a new Cornell study. , Moreover, such teens had ... did not eat nonfood substances. , Pregnant teens, regardless ... which can lead to iron deficiency and anemia. Low ...
Breaking Biology News(10 mins):Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3Pica in pregnant teens linked to low iron 2
... explain the complexities of the origins of life. Their work, ... Interface , offers new insights into how RNA signaling likely ... that today,s genetic code probably resulted from a combination of ... student at NYU School of Medicine and the paper,s lead ...
... When a woman becomes pregnant, she knows it is important ... of herself and the health of her baby. New clinical ... Eurpean Federation of Periodontology (EFP) urge pregnant women to maintain ... periodontal disease may be at risk of adverse pregnancy outcomes, ...
... role of microbiology in agriculture combined with new technologies ... population increases according to a new report from the ... are essential partners in all aspects of plant physiology, ... solely on the plant," says Ian Sanders of University ...
Cached Biology News:Researchers develop model of 'near-optimal' genetic code 2Expectant mothers' periodontal health vital to health of her baby 2Report proposes microbiology's grand challenge to help feed the world 2
(Date:8/22/2014)... Greenville, SC (PRWEB) August 22, 2014 ... that indisputable acknowledgement is a national disgrace. Furthermore, ... part in establishing the current, deplorable state of ... outlined "5 great mistakes," to merely serve as ... convey the extent of colossal failure(s) that have ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 ... Fertilizer Industry” is a professional and in-depth ... The report provides basic Seaweed Fertilizer information, ... industry chain structure as well as industry ... analysis, including domestic market as well as ...
(Date:8/21/2014)... BURLINGTON, Mass. , Aug. 21, 2014 /PRNewswire/ ... in Brazil and ... restrictions. The uptake of several newly approved agents, ... for this indication and the launch of emerging ... asthma markets. In particular, the emerging IL-5 inhibitors ...
(Date:8/21/2014)... Chester, NJ (PRWEB) August 21, 2014 ... of personal selling optimization technology and services for ... publication of “Grading Pharma’s Use of New Commercial ... of Measurement & Analytics. , The article examines ... marketing yield that are being tested in the ...
Breaking Biology Technology:5 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2
... -- Bruker AXS Inc. on Thursday announced the promotions ... to executive vice presidents, responsible for leading all aspects ... the Madison headquarters of Bruker AXS, now leads the ... as chief technology officer heads global R&D. , ,Burgaezy, ...
... describes today's go-it-alone economic climate than the word "entrepreneur." ... appealing to those who would strike out on their ... large and small along with colleges and universities and ... to help them in their quests to be successful ...
... CHICAGO -Last week, we talked about the size and ... key market segments. This week's column will focus on the ... , ,Before we comment on some trends from this ... absent here is the major part of the diagnostics business ...
Cached Biology Technology:Beware -- Use of the word 'entrepreneur' can put you in a legal mess 2Beware -- Use of the word 'entrepreneur' can put you in a legal mess 3Beware -- Use of the word 'entrepreneur' can put you in a legal mess 4Beware -- Use of the word 'entrepreneur' can put you in a legal mess 5Midwest plays key role in developing new medical device companies 2Midwest plays key role in developing new medical device companies 3
sterile filtered, off the clot, all male donors, Total Protein: 4.5 to 8.5 g/dl...
Recombinant Mouse MMP-9, CF...
Human/Mouse/Rat JNK Pan Specific Affinity Purified PAb...
Blue Standard is 3-cyano-7-hydroxycoumarin....
Biology Products: