Navigation Links
Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
Date:4/23/2012

PITTSBURGHUsing a new fluorescent biosensor they developed, researchers at Carnegie Mellon University have discovered how a key set of immune cells exchange information during their coordinated assault on invading pathogens. The immune cells, called dendritic cells, are harnessed by cancer vaccines and other therapeutics used to amplify the immune system. The finding, published online March 29 in the journal Angewandte Chemie, marks the first time that scientists have visualized how antigens are transferred in the immune system between dendritic cells.

"Knowing the mechanism behind what's going on in these dendritic cells how they are talking to each other in order to amplify the immune response is of fundamental significance," said Marcel P. Bruchez, associate professor of biological sciences and chemistry in the Mellon College of Science.

Dendritic cells are specialized immune cells that search for and capture foreign micro-organisms like bacteria, allergens or viruses. The cells engulf the invading organism and break it down into pieces. The dendritic cell then places these pieces, called antigens, on its cell surface.

When a dendritic cell presents antigens on its surface, it instructs other immune cells to multiply and scour the body in search of the harmful micro-organisms. Dendritic cells also can share antigens with other dendritic cells to boost immune cell activation. While scientists knew that antigens from one dendritic cell could show up in another dendritic cell, they didn't know how those antigens got there.

To determine the precise mechanism by which dendritic cells transfer antigens to each other, the research team used a new pH-biosensor developed at Carnegie Mellon's Molecular and Biosensor Imaging Center (MBIC). The biosensor is made up of two components: a fluorogen activating peptide (FAP), which is genetically expressed in a cell and tagged to a protein of interest, and a dye called a fluor
'/>"/>

Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-268-9982
Carnegie Mellon University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Carnegie Mellon to receive $900,000 from EPA for brownfields research
2. Carnegie Mellons Philip LeDuc participates in think tank forums
3. Carnegie Mellon developing automated systems to enable precision farming of apples, oranges
4. Carnegies Field and Koshland Elected AAAS Fellows
5. Carnegie Mellon to unveil new sequestration plan
6. Carnegies Arthur Grossman receives Gilbert Morgan Smith medal
7. Carnegies Joe Berry elected Fellow of the American Geophysical Union
8. Carnegies Doug Koshland elected Fellow of the American Academy of Microbiology
9. Carnegies Donald Brown receives lifetime achievement award from Society for Developmental Biology
10. Carnegie Mellon researchers apply new statistical test
11. Carnegie Mellons Kris Matyjaszewski recieves EPAs Presidential Green Chemistry Challenge Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... VIEW, Calif. , July 7, 2015 /PRNewswire/ ... biometrics market, Frost & Sullivan recognizes Credence ID, ... Sullivan Entrepreneurial Company of the Year Award. ... suite to aid in its mission of offering ... under-recognized populations globally. As Credence ID was formed ...
(Date:7/2/2015)... 2015 Research and ... the "Natural Language Processing Market by Type ... Pattern & Image Recognition) - Worldwide Forecast to ... The key vendors occupying the market are 3M, ... Corporation, NetBase Solutions, SAS Institute Inc., Verint Systems ...
(Date:7/2/2015)... Fingerprint Cards has received an order ... from the distributor World Peace Industrial Group (WPI), part of ... Asia . Deliveries are planned to take place ... by smartphone manufacturers in Asia . The ... revenue guidance of approximately 2,200 MSEK for 2015. ...
Breaking Biology News(10 mins):Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... at Michigan State University have shown a prebiotic may ... infection and reduce inflammation, greatly decreasing the risk of ... as food for the trillions of tiny bacteria living ... growth of the "good" bacteria. The evolution of prebiotic ...
... presented at Europe,s leading breast cancer translational research conference ... differences between individual breast cancers. Focused on ... sensitive to important therapies, the new studies will help ... for millions of patients. "Despite major advances in ...
... of long-forgotten habitats and the resurgence of species unseen for ... natural disaster. Yet that,s exactly what researchers have found on ... earthquake and devastating tsunami in 2010. Their study also revealed ... a major symptom of climate change. In a ...
Cached Biology News:Researchers show prebiotic can reduce severity of colitis 2New data improve understanding of breast cancer's multiple varieties 2New data improve understanding of breast cancer's multiple varieties 3New data improve understanding of breast cancer's multiple varieties 4New data improve understanding of breast cancer's multiple varieties 5New data improve understanding of breast cancer's multiple varieties 6First-of-its-kind study reveals surprising ecological effects of earthquake and tsunami 2First-of-its-kind study reveals surprising ecological effects of earthquake and tsunami 3
(Date:7/27/2015)... July 27, 2015 The Brain ... winners of its annual Klerman and Freedman Prizes, ... who have been supported by NARSAD Young Investigator ... pursue innovative ideas in neurobiological and psychosocial research, ... for the early detection, treatment, prevention and cure ...
(Date:7/27/2015)... Maine , July 27, 2015 IDEXX ... more than 8,000 clinics have submitted over 100,000 specimens ... testing in just the first 10 days since the ... kidney disease (CKD) is a leading cause of suffering ... the submitted specimens are consistent with generally accepted kidney ...
(Date:7/26/2015)... ... July 26, 2015 , ... Maine ... calibration verification / linearity test kit. The VALIDATE® ANEMIA kit contains Ferritin, Folate, ... is prepared using the CLSI recommended “equal delta” method for linearity testing and ...
(Date:7/24/2015)... -- Ryan & Maniskas, LLP that a class ... for the Northern District of California ... common stock of Avalanche Biotechnologies, Inc. ("Avalanche" or the "Company") ... 15, 2015, inclusive (the "Class Period"). Avalanche shareholders ... for appointment as a lead plaintiff of the Class.  If ...
Breaking Biology Technology:Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 2Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 3Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 4Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 5Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 6Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 2Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 3Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 4Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 5Maine Standards Company, LLC Announces Release of VALIDATE® ANEMIA Calibration Verification / Linearity Test Kit 2Ryan & Maniskas, LLP Announces Class Action Lawsuit Against Avalanche Biotechnologies, Inc. 2Ryan & Maniskas, LLP Announces Class Action Lawsuit Against Avalanche Biotechnologies, Inc. 3
... Northwest,Biotherapeutics, Inc. (OTC Bulletin Board: NWBO; AIM: NWBT and ... and Promissory Note,(the "Note") with SDS Capital Group SPC, Ltd ... Note is an unsecured obligation of,the Company and accrues interest ... Note is six months, with a maturity date of April ...
... PARIS, Oct. 1 The 2008 Frost & ... of the Year,Award is presented to Biospace Lab ... product portfolio. The company,s outstanding,product line has allowed ... leading to increased market share., "An in-depth ...
... Horizon Therapeutics, Inc., a,privately held biopharmaceutical company, ... executive officer, will present a corporate,overview at the ... on,Tuesday, October 7 at 9 a.m. ET at ... Therapeutics, Horizon Therapeutics, Inc. is a late-stage ...
Cached Biology Technology:Northwest Secures US$1.0 Million Debt Financing 2Northwest Secures US$1.0 Million Debt Financing 3Northwest Secures US$1.0 Million Debt Financing 4Small Animal Imaging Market: Biospace Lab Wins Frost & Sullivan Accolade for Its Successful Product Line Strategy 2Small Animal Imaging Market: Biospace Lab Wins Frost & Sullivan Accolade for Its Successful Product Line Strategy 3Small Animal Imaging Market: Biospace Lab Wins Frost & Sullivan Accolade for Its Successful Product Line Strategy 4
... ion exchange media are rigid macroporous hydrophilic ... flow rates at moderate pressures, while the ... and the hydrophilic matrix reduces nonspecific binding. ... strong anion exchanger with very high flow ...
... collection of phage display libraries, human ... and mouse tissues. All cDNA libraries ... size of cDNA inserts has been ... 1000bp by gel electrophoresis of DNA ...
... IDS Corticosterone kit is a competitive enzymeimmunoassay ... in mouse or rat serum or plasma. ... corticosteroid in rats and mice, and in ... and reptiles. Most mammals produce both corticosterone ...
Mouse monoclonal [1.F.1] to Yersinia pestis F1 antigen ( Abpromise for all tested applications). Antigen: Purified F1 antigen of Y. pestis vaccine strain EB....
Biology Products: