Navigation Links
Carnegie Mellon first to measure energy released from a virus during infection
Date:2/5/2010

unctional genes into the viral delivery system is one of the key factors involved in developing a successful gene therapy.

Many viruses, whether they infect bacteria, plants or animals, are adept at packing long stretches of nucleic acid (DNA or RNA) within their nanometer-sized protein shells. In many of the viruses that contain double-stranded DNA, the DNA gets packaged so tightly that it bends upon itself, resulting in repulsive forces that exert a tremendous amount of pressure on the virus's outer shell, indicating a great amount of stored energy. At the moment of infection, when the DNA is being shot out of the virus, the energy stored in the tightly packed DNA is released and converted into thermal energy.

Evilevitch and his colleagues from Lund University in Sweden, where Evilevitch was previously employed, and the Universite de Lyon in France used an experimental technique known as isothermal titration calorimetry (ITC) to directly measure the heat, and thus the thermal energy, released during viral genome ejection. Until now, only indirect measurements of this energy have been available. They describe this new method in the Feb. 5 issue of the Journal of Molecular Biology.

"We are the first group to use titration calorimetry to study genome release from viruses," Evilevitch said. "In this study, we looked at viruses that infect bacteria, called bacteriophages, as an experimental model system, but ITC can also be applied to other types of viruses. We're currently investigating the rotavirus, which causes stomach flu, using our new technique."

In the Journal of Molecular Biology report, Evilevitch used ITC to measure the thermal energy released during genome ejection, which is the same as the stored internal energy that results from genome packaging. His results, which agree with analytical models and computer simulations, show that the heat released increases as DNA length increases. He also discovered that
'/>"/>

Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-268-9982
Carnegie Mellon University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
2. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
3. Carnegie Mellon scientist uses mass spectrometer to weigh virus particle, von Willebrand factor
4. Carnegie Mellon, Pitt Team to study psychosocial stress
5. Mellon awards Carnegie Grant for Ecological Monitoring in South Africa
6. Carnegie Mellon researchers to develop new drug delivery system
7. Carnegie Mellon students win contest
8. Novel mechanism for long-term learning identified by Carnegie Mellon researchers
9. U. Mass Medical School and Carnegie announce licensing agreements with Oxford BioMedica
10. Carnegie Mellon scientists develop fluorescent proteins for live cell imaging, biosensor design
11. Carnegie Mellon receives $1.85 million
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has ... Market 2015-2019" report to their offering. ... grow at a CAGR of 23.5 percent over the ... scenario and the growth prospects of the Global Iris ... market size, the report considers the revenue generated from ...
(Date:3/23/2015)... BOSTON, Mass , March 23, 2015 SoundView ... shipment of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView ... world user feedback on their experience with the Wocket in ... experience at CVS, Whole Foods and other retailers, making both ... Kris Tuttle also says, "If the company meets ...
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3
... cousin of the bacterium that debilitated thousands of World War ... who had been on an international vacation. The woman, who ... typhoid fever, two infections that can occur in returning travelers. ... was infected with a new bacterium that had never before ...
... a single protein with an experimental drug prevented and ... mice that had been fed unhealthy diets and were ... article published online at Nature on June 6, 2007. ... chair of the Department of Genetics and Complex Diseases ...
... new clues to a very cold case: the disappearance of ... all Ice Age giants, according to a June 7th report ... , DNA lifted from the bones, teeth, and tusks of ... expansion after the last interglacial period. After the mammoths’ migration, ...
Cached Biology News:New bacterium discovered -- related to cause of trench fever 2New bacterium discovered -- related to cause of trench fever 3New bacterium discovered -- related to cause of trench fever 4In mice, drug protects against diabetes and atherosclerosis 2In mice, drug protects against diabetes and atherosclerosis 3In mice, drug protects against diabetes and atherosclerosis 4Ancient DNA traces the woolly mammoth's disappearance 2
(Date:5/5/2015)... 2015 ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") (NYSE ... President and Chief Executive Officer, will present live ... DATE:  Thursday, May 7, 2015     TIME:  11:30 am ET/8:30 ... click the red "register/ watch presentations" button ... event where investors are invited to ask the ...
(Date:5/5/2015)... DUBLIN , May 05, 2015 Research ... announced the addition of the "Clinical Laboratory, ... and Forecasts 2015 to 2019 - Europe Version" ... technical developments especially in the area of molecular ... dynamic, growing and evolving world market that is ...
(Date:5/5/2015)... Station, TX (PRWEB) May 05, 2015 ... were announced last week as recipients of the ... Innovation in recognition of their Portable, Continuous, Miniature ... that integrates a small footprint, continuous processing equipment, ... modules) to process API powders and inactive ingredients ...
(Date:5/4/2015)... May 4, 2015 Tobira Therapeutics, Inc. ... the development and commercialization of novel treatments for ... of its merger with Regado Biosciences, Inc. (NASDAQ: ... closing of the merger, Tobira raised $40 million ... investors and all current Tobira institutional investors, including ...
Breaking Biology Technology:ImmunoCellular Therapeutics to Webcast Live at VirtualInvestorConferences.com on May 7 2European Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market 2015-2019 2GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 2GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 3Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 2Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 3Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 4Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 5Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 6
... 23, 2010 In a world where millions suffer daily ... out as the definitive leader in natural, safe and effective ... Now, patients are raving about the amazing results of the ... (Menstrual) is the first of its kind supplement ...
... 23, 2010 HRC Medical Center is passionate about ... the most technologically advanced methods of Bio-Identical Hormone Therapy ... energy, depression, decreased sex drive, memory loss, anxiety, joint ... of muscle tone, chances are you may have a ...
... COLLEGE PARK, Md., Dec. 23, 2010 Martek Biosciences, ... Institute (Mtech) at the University of Maryland, entered an ... Dutch company Royal DSM NV for $1.1 billion, the ... Martek is the second company sold ...
Cached Biology Technology:A Breakthrough for Migraines, PMS and PCOS! 2HRC Medical Center Offers Patients Relief with Innovative Bio-Identical Hormone Replacement Therapy 2Martek Is Second Mtech Company Sold for More Than $1 Billion in Three Years 2Martek Is Second Mtech Company Sold for More Than $1 Billion in Three Years 3Martek Is Second Mtech Company Sold for More Than $1 Billion in Three Years 4