Navigation Links
Carnegie Mellon first to measure energy released from a virus during infection
Date:2/5/2010

PITTSBURGHWithin a virus's tiny exterior is a store of energy waiting to be unleashed. When the virus encounters a host cell, this pent-up energy is released, propelling the viral DNA into the cell and turning it into a virus factory. For the first time, Carnegie Mellon University physicist Alex Evilevitch has directly measured the energy associated with the expulsion of viral DNA, a pivotal discovery toward fully understanding the physical mechanisms that control viral infection and designing drugs to interfere with the process.

"We are studying the physics of viruses, not the biology of viruses," said Evilevitch, associate professor of physics in the Mellon College of Science at Carnegie Mellon. "By treating viruses as physical objects, we can identify physical properties and mechanisms of infection that are common to a variety of viruses, regardless of their biological makeup, which could lead to the development of broad spectrum antiviral drugs."

Current antiviral medications are highly specialized. They target molecules essential to the replication cycle of specific viruses, such as HIV or influenza, limiting the drugs' use to specific diseases. Additionally, viruses mutate over time and may become less susceptible to the medication. Evilevitch's work in the burgeoning field of physical virology stands to provide tools for the rational design of less-specialized antiviral drugs that will have the ability to treat a broad range of viruses by interrupting the release of viral genomes into cells.

Evilevitch's current findings also have the potential to improve the development of gene therapy, which uses viruses to deliver functional genes directly to human cells to replace defective genes that are causing disease. Gene therapy takes advantage of viruses' modus operandi injecting genetic material into cells. But instead of forcing in harmful, viral DNA, gene therapy delivers helpful, functional genes. Controlled packaging of the f
'/>"/>

Contact: Jocelyn Duffy
jhduffy@andrew.cmu.edu
412-268-9982
Carnegie Mellon University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Carnegie Mellon scientists develop nanogels that enable controlled delivery of carbohydrate drugs
2. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
3. Carnegie Mellon scientist uses mass spectrometer to weigh virus particle, von Willebrand factor
4. Carnegie Mellon, Pitt Team to study psychosocial stress
5. Mellon awards Carnegie Grant for Ecological Monitoring in South Africa
6. Carnegie Mellon researchers to develop new drug delivery system
7. Carnegie Mellon students win contest
8. Novel mechanism for long-term learning identified by Carnegie Mellon researchers
9. U. Mass Medical School and Carnegie announce licensing agreements with Oxford BioMedica
10. Carnegie Mellon scientists develop fluorescent proteins for live cell imaging, biosensor design
11. Carnegie Mellon receives $1.85 million
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... a cell divides, it must first make a copy of ... cells that occurs billions of times a day in the ... molecular tools that cells use to replicate DNAthe enzymes that ... have a clear picture of how the process works. , ... system to decipher what goes on at the "replication fork"the ...
(Date:7/8/2014)... the world,s coral reefs and the animals that depend ... one tiny symbiotic sea creature to get fatand to ... with. , In the first study of its kind, ... reef-forming animals that live symbiotically with algaeare better able ... "bleaching," when they keep large energy reservesmostly as fatsocked ...
(Date:7/8/2014)... an increased risk of severe perineal tearing during childbirth in ... suggests a new study published today (9 July) in ... , This study, investigates among women who have had a ... in subsequent pregnancies and the recurrence of severe perineal tears. ... and in some women the tear may be more extensive. ...
Breaking Biology News(10 mins):Rockefeller scientists first to reconstitute the DNA 'replication fork' 2Rockefeller scientists first to reconstitute the DNA 'replication fork' 3Rockefeller scientists first to reconstitute the DNA 'replication fork' 4For corals adapting to climate change, it's survival of the fattest -- and most flexible 2For corals adapting to climate change, it's survival of the fattest -- and most flexible 3For corals adapting to climate change, it's survival of the fattest -- and most flexible 4Mode of delivery following a perineal tear and recurrence rate in subsequent pregnancies 2
... of North Carolina Hospitals arrived in February sporting three ... in helping to repair heart valves, remove cancerous prostates, ... for morbid obesity. , The new arrival is a ... Intuitive Surgical. UNC currently is the only gynecological oncology ...
... of North Carolina Hospitals arrived in February sporting three ... in helping to repair heart valves, remove cancerous prostates, ... for morbid obesity. , The new arrival is a ... Intuitive Surgical. UNC currently is the only gynecological oncology ...
... disease and climate change may have applications for ... American Phytopathological Society (APS). , According to David ... plants possess unique mechanisms of resistance to microbial ... able to apply the novel mechanisms found in ...
Cached Biology News:FDA: 'Highly Unlikely' Green Tea Lowers Cancer Risk 2FDA: 'Highly Unlikely' Green Tea Lowers Cancer Risk 3Screen all at risk for HIV, plus pregnant women 2Screen all at risk for HIV, plus pregnant women 3
(Date:1/15/2014)... Look inside the new Preferred Solutions® ... lab, from fluid handling to instruments to supplies. Many ... you order. , Preferred Solutions features a full ... L/S® model for precise flow control and dispensing to ...
(Date:1/15/2014)... England , January 15, 2014 A ... win races on the Formula 1 track could help to ... McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based in ... by healthcare provider Simplyhealth. Telemetry technology, which is ...
(Date:1/15/2014)... 15, 2014 2013 was a banner ... State Technologies®. They saw continued independent research led by ... were awarded a $1 million grant from the Susanne ... and Behavior” a peer reviewed journal, Amy Grant highlighted ...
(Date:1/14/2014)... Washington, DC (PRWEB) January 14, 2014 ... session for Thursday, January 23, 2014 at 2pm EST ... Actionable Knowledge.” The topic focuses on how technology can ... mission critical decisions for government agencies. The online webinar ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... 25 Tengion Inc., a clinical stage regenerative medicine company focused ... Nichtberger, M.D., President and Chief Executive Officer of Tengion, will present ... 2, 2008 at 9:50 a.m. EST at The Palace Hotel in ... About Tengion , , ...
... RICHMOND, Va., Nov. 25 Insmed Inc. (Nasdaq: ... today that Dr. Geoffrey Allan, President and CEO of Insmed, ... View Conference on December 3, 2008, in New York. , ... conference is to better educate the investment community on the ...
... (Nasdaq: IDEV ) today announced its consolidated results,of ... September,30, 2008. The Company will host a conference call ... below). , The Company ... 18% from fiscal 2007 revenues of $66.1 million. For ...
Cached Biology Technology:Insmed to Present at Sanford C. Bernstein Biosimilars Long View Conference 2Indevus Pharmaceuticals Announces Fiscal 2008 Year End and Fourth Quarter Results 2Indevus Pharmaceuticals Announces Fiscal 2008 Year End and Fourth Quarter Results 3Indevus Pharmaceuticals Announces Fiscal 2008 Year End and Fourth Quarter Results 4Indevus Pharmaceuticals Announces Fiscal 2008 Year End and Fourth Quarter Results 5Indevus Pharmaceuticals Announces Fiscal 2008 Year End and Fourth Quarter Results 6Indevus Pharmaceuticals Announces Fiscal 2008 Year End and Fourth Quarter Results 7Indevus Pharmaceuticals Announces Fiscal 2008 Year End and Fourth Quarter Results 8Indevus Pharmaceuticals Announces Fiscal 2008 Year End and Fourth Quarter Results 9Indevus Pharmaceuticals Announces Fiscal 2008 Year End and Fourth Quarter Results 10Indevus Pharmaceuticals Announces Fiscal 2008 Year End and Fourth Quarter Results 11
... numbers of samples may be carried out using ... minimum operator attention. System control and data ... CE 4900. The elegant, powerful and very ... and Windows 98 and 2000., The supplied automatic ...
Heavy-duty rim. Especially recommended as a titration flask. Corning5100. capacity 250 mL Special grade: student grade...
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (F1676) or contact customer s...
Mouse monoclonal [YPF19] to Yersinia pestis F1 antigen ( Abpromise for all tested applications)....
Biology Products: