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Cardium Reports on Presentation at American Heart Association Meeting Relating to Gene Delivery to the Heart and Generx Clinical Development
Date:11/15/2010

SAN DIEGO, Nov. 15, 2010 /PRNewswire/ -- Cardium Therapeutics (NYSE Amex: CXM) reported on the presentation of results from the Company's sponsored preclinical research at the American Heart Association 2010 Annual Meeting Scientific Sessions being held November 13 – 17, 2010 in Chicago, IL.  The new findings showed that coronary artery occlusion and reperfusion can substantially increase adenovector-mediated gene delivery to the heart, which is used in the Company's Generx product candidate.

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Cardium's Generx (Ad5FGF-4) clinical development program, including four completed clinical studies enrolling over 650 patients worldwide, has generated data indicating that the level of myocardial ischemia in patients with severe coronary artery disease may affect the angiogenic response in patients.  These new findings indicate that induced myocardial ischemia and reperfusion can increase adenovector uptake by heart muscle which could potentially be applied to enhance the delivery of DNA encoding growth factors to the heart as used in the Company's Generx product candidate.  Generx is designed for potential use by interventional cardiologists as a one-time treatment to promote and stimulate the growth of collateral circulation in the hearts of patients with ischemic conditions, such as recurrent angina, due to coronary artery disease.  A new presentation entitled New Cardiovascular Therapeutic Paradigm: Development and Commercialization of Cost-Effective DNA-Based Angiogenic Therapeutic for International Markets, is now available for viewing at the Investors Section of Cardium's website at http://phx.corporate-ir.net/phoenix.zhtml?c=77949
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