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Cardiac cell transplant studies show promise in cardiac tissue repair
Date:9/3/2008

ema could be of paramount importance if specific combinations of differentiated cell phenotypes are to be obtained," said Severio Sartore, PhD, the study's lead author. "The study found that "the capability of both MSCs to be converted to CM-like cells (cardiomyocyte or heart muscle cells) is quite low and many cells appear with more than one nucleus"

It was unclear to researchers whether those cells had divided or fused. Furthermore, although both MSCs have "similar biological profiles" they did not possess equal differentiation potential.

"The differentiation potentials of MSCs observed in vitro need a definitive in vivo confirmation for future cell therapy experiments aimed at replenishing damaged cardiovascular tissue," concluded Sartore and his team. "While the two MSCs can contribute roughly at the same extent to capillary formation, AF-MSCs are not able to participate in the formation of arterioles and hence to vascular SMCs (smooth muscle cells)."

Sartore noted that in previous studies when AF-MSCs were transplanted into porcine models of myocardial ischemia they were converted to vascular cells, but not to cardiomyocytes.

"Both of these papers further help delineate the evolving role of bone marrow in cardiac cell therapy, not only as a regenerative means but also supportive to other cells and tissues" said Amit N. Patel, M.D., director of cardiovascular regenerative medicine and associate professor of surgery at the University of Utah School of Medicine, and a section editor for CELL TRANSPLANTATION.


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Contact: Tao-Sheng Li, MD, PhD
litaoshe@yamaguchi-u.ac.jp
81-836-222-260
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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