Navigation Links
Cardiac cell transplant studies show promise in cardiac tissue repair
Date:9/3/2008

Tampa, Fla. (Sep. 3rd, 2008) Two studies published in the current issue of CELL TRANSPLANTATION (17:6) examine the efficacy of transplanting bone marrow cells (BMCs) for the repair of heart tissue.

The first study found that implanting adult cardiomyocytes (heart muscle cells) in combination with BMCs has two advantages over transplanting cardiomyocytes alone. First, while cardiac function was preserved by implanting cardiomyocytes alone, the therapeutic effects of transplanting them along with bone marrow cells was enhanced. Second, programmed cell death (apoptosis) of the host cardiomyocytes was reduced significantly after the implantation of BMCs alone or in combination with cardiomyocytes when compared with results after the implanting of cardiomyocytes alone.

"Our findings indicate that cardiomyocytes and bone marrow cells can assist and compliment each other," said the study's lead author Tao-sheng Li, MD, PhD of the Department of Surgery and Clinical Science at the Yamaguchi University Graduate School of Medicine. "This technique shows promise as a feasible new strategy for myocardial repair."

Cardiomyocyte survival was counted at one, three and seven days after culture to see if protection against apoptosis was successful.

Cardiac function was measured before and 28 days after treatment. Results showed that cardiomyocyte survival increased significantly in the co-cultured group. Although cardiomyocytes shrank as the post-culture time was extended, morphological change was milder in the co-cultured group.

The second study, carried out at the University of Padua, compared transplantation of two sources of mensenchymal stem cells (MSCs) derived from bone marrow (BM-MSCs) and from fetal amniotic fluid (AF-MSCs) to discover which type of cell was most effective in replenishing damaged rat heart tissues.

"The choice of stem cell type to be used in therapeutic cardiovascular regeneration of acute or chronic myocardial isch
'/>"/>

Contact: Tao-Sheng Li, MD, PhD
litaoshe@yamaguchi-u.ac.jp
81-836-222-260
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. A home early warning system for cardiac patients
2. CU-Boulder, biotech firm team up on python project in search for human cardiac therapeutics
3. Implanting embryonic cardiac cells prevents arrhythmias
4. Pennsylvania Hospital surgeon receives grant to develop molecular cardiac surgery
5. University of Pittsburgh cardiologists identify new cardiac arrest gene
6. Ikaria(R) Receives FDA Orphan Drug Designation for Inhaled Carbon Monoxide for Delayed Graft Function in Solid Organ Transplants
7. Ikaria(R) Receives FDA Orphan Drug Designation for Inhaled Carbon Monoxide for Delayed Graft Function in Solid Organ Transplants
8. Predicting acute GVHD by gene expression could improve liver stem cell transplant outcomes
9. Researchers discover link between organ transplantation and increased cancer risk
10. Neural cell transplants may help those with Parkinsons disease
11. Stroke victims may benefit from stem cell transplants

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/8/2009)... WEST LAFAYETTE, Ind. - Researchers at Purdue Univ...g damaged nerve fibers in spinal cord injuries usi...ood shortly after an accident. , The synthetic "...t 60 nanometers in diameter, or roughly 100 times ... Researchers have been studying how to deliver dru...
(Date:11/6/2009)...ee-dwelling ants generally live in harmony with th... when they run out of space in their trees of choi...ees. , The research, published in the November i... document that ants bore into live trees, and it r...between ants and plants. , Ants and certain spec...
(Date:11/5/2009)...nt State University has been awarded a training gr...ience Foundation under its Integrative Graduation ...his is the first IGERT grant to be awarded to Kent...can Recovery and Reinvestment Act of 2009, runs th...hat focuses on environment aquatic resource sensin...
Breaking Biology News(10 mins):Findings show nanomedicine promising for treating spinal cord injuries 2Findings show nanomedicine promising for treating spinal cord injuries 3Ants are friendly to some trees, but not others 2Kent State receives $2.7 million NSF training grant for environmental aquatic resource sensing 2Sysmex America Debuts High end Sample Management System During AACC 52129 1Sysmex America Debuts High end Sample Management System During AACC 52129 2Sysmex America Debuts High end Sample Management System During AACC 52129 3Understanding Managed Markets 3A Effective Market Research Structures 26 Activities to Maximize Payer Access 26 Insights 13093 1Understanding Managed Markets 3A Effective Market Research Structures 26 Activities to Maximize Payer Access 26 Insights 13093 2Internet May Be Newest Venue for Teen Tobacco Exposure 52122 1Internet May Be Newest Venue for Teen Tobacco Exposure 52122 2Internet May Be Newest Venue for Teen Tobacco Exposure 52122 3
...Presbycusis, or age-related hearing loss, accounts...ome people lose their hearing as they get older bu... answer may be in a study released online in the j...is available online at http://hmg.oxfordjournals....r and largest genome-wide association study for ag...
...g widespread consumption advisories and uncertaint...at. Now researchers at North Carolina State Univer...sts and regulators around the country predict whic...levels a breakthrough that should help officials ...visories for specific water bodies and fish specie...
...oration of Stanford University,s Woods Institute f... World Wildlife Fundhas been awarded a two-year, $... Foundation to develop a software program for mapp...by temperate marine ecosystems. , Called Marine I...and Tradeoffs), the proposed software will give po...
Other Biology News:House Ear Institute, TGen and Belgian researchers identify gene in age-related hearing loss 2New model predicts hot spots for mercury in fish 2Natural Capital Project to develop conservation software 2
(Date:11/6/2009)... The agenda for Arrowhead’s 201...hich is set to take place on February 22-24, 2010 ... day conference we will highlight key issues in fo... share their experiences. , ... agenda for Arrowhead’s 2010 Personalized M...
(Date:11/5/2009)...RSBURG, Md., Nov. 5 GenV...ncial results for the third quarter ended Septembe...lion ($0.04 per share) for the three months ended ...million ($0.08 per share) in the comparable quarte... 2009, GenVec,s net loss was $14.1 million ($0.15 ...
(Date:11/5/2009)...PANY, N.J., Nov. 5 DSM Pharmaceuti...nufacturing alliance with Galenix, Saint Jean D,Il...rcial scale manufacturing partner for Galenix comm...alenix will collaborate on business development op...hnologies, based on the strength of Galenix in dru...
(Date:11/5/2009)... CORDOVA, Calif., Nov. 5 ...upplier of innovative products for processing and ...or the first quarter of fiscal 2010. ,, For the...orted revenues of $5.2 million, a 15 percent incre...rter a year ago. The Company said the key contribu...
Breaking Biology Technology:Leaders in Biopharma and Molecular Diagnostics to Discuss Key Issues and Opportunities in Forming Partnerships at 2010 Personalized Medicine Partnerships Conference 2Leaders in Biopharma and Molecular Diagnostics to Discuss Key Issues and Opportunities in Forming Partnerships at 2010 Personalized Medicine Partnerships Conference 3GenVec Reports Third Quarter 2009 Financial Results 2GenVec Reports Third Quarter 2009 Financial Results 3GenVec Reports Third Quarter 2009 Financial Results 4GenVec Reports Third Quarter 2009 Financial Results 5GenVec Reports Third Quarter 2009 Financial Results 6DSM Pharmaceutical Products Forms Manufacturing Alliance With Galenix 2DSM Pharmaceutical Products Forms Manufacturing Alliance With Galenix 3ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 2ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 3ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 4ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 5ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 6ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 7ThermoGenesis Reports 15 Percent Increase in First Quarter Revenues; Improved Bottom Line 8
... Mass., Oct. 8 Inverness Medical,Innovations (Ame... a Scheme,Implementation Agreement with Panbio Ltd...ecurities Exchange, under which it is proposed tha...in Panbio for AUD 0.65 cash,per share. The propose...,Panbio at approximately AUD 41 million, or approx...
... HEIGHTS, N.J., Oct. 8 Clinsys Clinical,Research,... organization,today announced the relocation of it...y,s significant growth and plans for future expans...ter, New Jersey. "Our new headquarters, combined ..., North Carolina and Dusseldorf, Germany, offers m...
...October 8 Innovation in the pharma industry is,no... once small molecule,research provided the mainsta...making their presence felt. While the range of gen...s are providing the current focus for novel,discov...cules; the rules,for their development are differe...
Other Biology Technology:Inverness Medical Innovations Agrees to Acquire Panbio Ltd. 2Clinsys Clinical Research, Inc. Announces Relocation of Corporate Headquarters 2Updated Drug Development Scrip Report Responds to the Pharma Industry's Major Changes 2
...2000 instrument can be used as a fully functional,...ger Software provides the means to record and tabu...hese data can then be copied and pasted into comme...Excel or Lotus 123, or into a curve-fitting progra...
Corning Cryo Box, 81 Position, 4-5 ml, Non-Sterile from Sigma-Aldrich
...oarray Kit (V2), 2 x 11K will enable researchers t...housands of yeast genes and identify gene activity...array contains sequences representing probes repre...Saccharomyces cerevisiae, sourced from the Sacchar...
...e offers an intuitive, easy-to-use operating envir...data handling, and integration with regulatory com...ude data acquisition, re-analysis, custom reports,...k environments. LCMSsolutions assistant bar provid...
Biology Products: