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Carbon nanotubes lower nerve-damaging chloride in cells
Date:12/10/2012

DURHAM, N.C. -- A nanomaterial engineered by researchers at Duke can help regulate chloride levels in nerve cells that contribute to chronic pain, epilepsy, and traumatic brain injury.

The findings, published online Dec. 10, 2012, in the journal Small, were demonstrated in individual nerve cells as well as in the brains of mice and rats, and may have future applications in intracranial or spinal devices to help treat neural injuries.

Carbon nanotubes are a nanomaterial with unique features, including mechanical strength and electrical conductivity. These characteristics, along with their tiny size, make them appealing to researchers in technology and medicine alike.

In a world of shrinking computers and smartphones, carbon nanotubes have been tapped as a solution for improving microchips. They outpace silicon microchips in size and performance, meeting a demand for smaller, faster devices. For people with nerve injury and certain neurological disorders, devices coated with or entirely made of carbon nanotubes could offer a new avenue for improving treatment options.

"Carbon nanotubes hold great promise for an array of applications, and we are only beginning to see their enormous potential," said lead author Wolfgang Liedtke, M.D., PhD, associate professor of medicine and neurobiology at Duke. "Their exceptional mechanical and electrical properties make them ideal for developing devices that interface with nervous tissues. However, the precise mechanisms behind carbon nanotubes and their effect on neurons remain elusive."

Not all carbon nanotubes are the same. Jie Liu, PhD, George Barth Geller Professor of Chemistry at Duke University and senior author of the study, developed specific carbon nanotubes that are extraordinarily pure. Termed few-walled carbon nanotubes, they have superior properties to their commercially-available counterparts.

Duke researchers initially set out to gauge if carbon nano
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Contact: Rachel Bloch Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center
Source:Eurekalert

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