Navigation Links
Carbon nanotubes form ultrasensitive biosensor to detect proteins
Date:6/27/2010

A cluster of carbon nanotubes coated with a thin layer of protein-recognizing polymer form a biosensor capable of using electrochemical signals to detect minute amounts of proteins, which could provide a crucial new diagnostic tool for the detection of a range of illnesses, a team of Boston College researchers report in the journal Nature Nanotechnology.

The nanotube biosensor proved capable of detecting human ferritin, the primary iron-storing protein of cells, and E7 oncoprotein derived from human papillomavirus. Further tests using calmodulin showed the sensor could discriminate between varieties of the protein that take different shapes, according to the multi-disciplinary team of biologists, chemists and physicists.

Molecular imprinting techniques have shown that polymer structures can be used in the development of sensors capable of recognizing certain organic compounds, but recognizing proteins has presented a difficult set of challenges. The BC team used arrays of wire-like nanotubes approximately one 300th the size of a human hair coated with a non-conducting polymer coating capable of recognizing proteins with subpicogram per liter sensitivity.

Central to the function of the sensor are imprints of the protein molecules within the non-conducting polymer coating. Because the imprints reduce the thickness of the coating, these regions of the polymer register a lower level of impedance than the rest of the polymer insulator when contacted by the charges inherent to the proteins and an ionized saline solution. When a protein molecule drops into its mirror image, it fills the void in the insulator, allowing the nanotubes to register a corresponding change in impedance, signaling the presence of the protein, according to co-author Dong Cai, an associate research professor of Biology at BC.

The detection can be read in real time, instead of after days or weeks of laboratory analysis, meaning the nanotube molecular
'/>"/>

Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert

Page: 1 2

Related biology news :

1. In elevated carbon dioxide, soybeans stumble but cheatgrass keeps on truckin
2. Enzyme trio for biosynthesis of hydrocarbon fuels
3. Storing carbon dioxide deep underground in rock form
4. Geochemist raises questions about carbon sequestration at Goldschmidt Conference
5. Delineating primary and secondary organic carbon in neoproterozoic glacial sediments
6. ORNL sows seeds with new agricultural carbon accounting tool
7. The search for improved carbon sponges picks up speed
8. Winners of ONRs Energy Challenge to help Navy reduce its carbon footprint
9. Study: Carbon monoxide exposure can be reduced during routine anesthesia in kids
10. New ORNL carbon composite holds promise for bionics
11. Carbon nanotubes boost cancer-fighting cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... team of scientists from Spain, France, and the ... that is the oldest definitive member of the ... amber. The discovery and description were made possible ... synchrotron imaging technique, which allows the detailed study ... new species is described in the journal ...
(Date:7/31/2014)... news release is available in German . ... can take up gases similar to a sponge that ... suited for storing hydrogen or greenhouse gases. However, loading ... Karlsruhe Institute of Technology (KIT) now report in ... cor-rosion of the MOF surface. This can be prevented ...
(Date:7/31/2014)... percent of animal models against the highly infectious and ... intestinal disease that kills approximately 30,000 Americans annually. The ... and Immunity . , In the study, the ... purified toxins produced by C. difficile , as ... model that mimics the human disease, after only two ...
Breaking Biology News(10 mins):Free pores for molecule transport 2C. difficile vaccine proves safe, 100 percent effective in animal models 2
... CLEVELAND Case Western Reserve,s Technology Transfer Office has ... (AD) treatment strategy to spinoff company ReXceptor Inc., which ... medication within the next few months. Gary Landreth, ... Neurosciences, and his then-graduate student, Paige Cramer, PhD, co-founded ...
... After years of scientific uncertainty and speculation, researchers at ... exactly how trees help create one of society,s predominant ... has long been known that trees produce and emit ... protect leaves from oxygen damage and temperature fluctuations. However, ...
... at Wake Forest University,s Organic Electronics group have come ... biggest technological barriers facing the organic semiconductor industry today. ... team of researchers developed a high performance organic semiconductor ... areas without losing electric conductivity. This is a potentially ...
Cached Biology News:Research spinoff ReXceptor gets license for Alzheimer's treatment 2Researchers pinpoint how trees play role in smog production 2High performance semiconductor spray paint could be a game changer for organic electronics 2
(Date:7/31/2014)... Calif. (PRWEB) July 31, 2014 Held ... diagnosed patients with an overview of the disease and ... of drug side effects, as well as updates on ... grateful to Dr. Sandy Srinivas for organizing this educational ... of kidney cancer. “Sandy and her colleagues have put ...
(Date:7/31/2014)... The global market for molecular diagnostics is ... to a new study by Grand View Research, Inc. ... subsequent introduction of advanced cancer diagnostic technologies are expected ... next six years. Moreover, the growing global base of ... with disease triggering lifestyle habits such as smoking and ...
(Date:7/31/2014)... IL (PRWEB) July 31, 2014 ... of automation across the U.S., increasing unemployment, depressing ... class. It is a Catch 22—we need ... but this means fewer jobs,” says economist and ... just-released Pollina Corporate Top 10 Pro-Business States for ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 ... and collaboration company, is proud to announce the ... LMS complements Adobe Connect’s elearning tools to quickly ... delivers content with training tools for desktop and ... with LMS is the perfect online training solution, ...
Breaking Biology Technology:Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 2Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 3Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 5ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4SoundConnect Enhances Portfolio with Adobe Connect Learning Management System (LMS) 2
... AIS is a provider of browser-based policy, ... the system allows business users to maintain much ... technical resources are conserved. The combination of Fiserv ... companies to automate customer communication, provide high levels ...
... ,You did it; you brought Bill Gates to his tender knees. ... campus. 'Curses, you worm writer, you!" It echoed among the buildings, ... teeth. And beneath the whimpers you could almost hear Billy saying ... money and fix my software."* , ,Wow, if only ...
... get techies into ballgame, too , ,As the ... recent or soon-to-be college grads may view a career ... could only see what really goes on in todays ... systems, robotic welding, remote sensoring and other modern staples ...
Cached Biology Technology:Open Letter: Blasted Worm 2Open Letter: Blasted Worm 3Manufacturing still viable career 2Manufacturing still viable career 3
...
Mouse monoclonal antibody raised against a full length recombinant ATF3. NCBI Entrez Gene ID = ATF3...
... The dsRNA Marker consists of ten double-stranded ... 300, 400, 500 and 1,000 base pairs. ... marker for determinating sizes of double-stranded RNAs. ... the dsRNA Marker is adjusted to approximately ...
... raised against a partial recombinant ... HD (NP_002102, 81 a.a. ... protein with GST tag. ... NM_002111 Protein ...
Biology Products: