Navigation Links
Carbon nanotubes form ultrasensitive biosensor to detect proteins
Date:6/27/2010

A cluster of carbon nanotubes coated with a thin layer of protein-recognizing polymer form a biosensor capable of using electrochemical signals to detect minute amounts of proteins, which could provide a crucial new diagnostic tool for the detection of a range of illnesses, a team of Boston College researchers report in the journal Nature Nanotechnology.

The nanotube biosensor proved capable of detecting human ferritin, the primary iron-storing protein of cells, and E7 oncoprotein derived from human papillomavirus. Further tests using calmodulin showed the sensor could discriminate between varieties of the protein that take different shapes, according to the multi-disciplinary team of biologists, chemists and physicists.

Molecular imprinting techniques have shown that polymer structures can be used in the development of sensors capable of recognizing certain organic compounds, but recognizing proteins has presented a difficult set of challenges. The BC team used arrays of wire-like nanotubes approximately one 300th the size of a human hair coated with a non-conducting polymer coating capable of recognizing proteins with subpicogram per liter sensitivity.

Central to the function of the sensor are imprints of the protein molecules within the non-conducting polymer coating. Because the imprints reduce the thickness of the coating, these regions of the polymer register a lower level of impedance than the rest of the polymer insulator when contacted by the charges inherent to the proteins and an ionized saline solution. When a protein molecule drops into its mirror image, it fills the void in the insulator, allowing the nanotubes to register a corresponding change in impedance, signaling the presence of the protein, according to co-author Dong Cai, an associate research professor of Biology at BC.

The detection can be read in real time, instead of after days or weeks of laboratory analysis, meaning the nanotube molecular
'/>"/>

Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert

Page: 1 2

Related biology news :

1. In elevated carbon dioxide, soybeans stumble but cheatgrass keeps on truckin
2. Enzyme trio for biosynthesis of hydrocarbon fuels
3. Storing carbon dioxide deep underground in rock form
4. Geochemist raises questions about carbon sequestration at Goldschmidt Conference
5. Delineating primary and secondary organic carbon in neoproterozoic glacial sediments
6. ORNL sows seeds with new agricultural carbon accounting tool
7. The search for improved carbon sponges picks up speed
8. Winners of ONRs Energy Challenge to help Navy reduce its carbon footprint
9. Study: Carbon monoxide exposure can be reduced during routine anesthesia in kids
10. New ORNL carbon composite holds promise for bionics
11. Carbon nanotubes boost cancer-fighting cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... Fla. , March 24, 2015   ... management solutions, today announced that its U.are.U ® ... accessory retailer Goorin Bros . to achieve ... biometrics-based solution secures access to the POS terminal, ... increased risk of data breaches. ...
(Date:3/23/2015)... 23, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... growing mobile commerce market, announces its biometric payment technology, the ... CNBC television starting March 30 th . ... New York markets. ... excited about our new ad campaign following the recent initial ...
(Date:3/20/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) ... Global Strategic Business Report" report to their offering. ... in US$ Thousands. The report provides separate comprehensive analytics for ... , Europe , Asia-Pacific ... Latin America . Annual estimates and ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... Calif. Conservation biologist Michael Allen will give a ... 6 titled "In the Crosshairs: California,s Environment." The hour-long lecture ... Doors open at 6:15 p.m. Seating is open. In his ... Conservation Biology at UC Riverside, plans to discuss what the ...
... STILLWATER, Okla. , April 27 Southwest Bancorp, Inc. (Nasdaq: ... offering of 4,000,000 shares of common stock at a price to the public ... million .  The offering was increased from the previously announced offering size of ... April 29, 2010 . , , ...
... Recently the media has begun to criticize those ... financial reform legislation, or Consumer Financial Protection Agency (CFPA).  Although ... weeks, possibly due to the fact that our Senate is ... of the sweeping bill, we are still not seeing this ...
Cached Biology News:Public lecture at UC Riverside to highlight California's environment 2Southwest Bancorp, Inc. Announces Pricing of $50 Million Underwritten Public Offering of Common Shares 2Southwest Bancorp, Inc. Announces Pricing of $50 Million Underwritten Public Offering of Common Shares 3Pay1Day Asks, Who is Writing our Proposed Consumer Protection Bill? 2
(Date:3/26/2015)... CINCINNATI , March 26, 2015 ... SHPG ) and Cincinnati Children,s Hospital Medical Center ... rare diseases. The goal of the collaboration is to ... diseases with high unmet medical need combining Shire,s ... expertise. As a nationally ranked hospital, Cincinnati Children,s ...
(Date:3/26/2015)... Texas (PRWEB) March 26, 2015 ReliantHeart, ... technologies, and Transonic, a supplier of precision transit-time flow ... that will greatly improve the efficiency of the ... enable LVAD patients to experience greater mobility and peace ... with the miniature flow board, will draw 1/6th of ...
(Date:3/26/2015)... 2015 WriteResult, a premier provider of ... Yale University’s School of Public Health and New Haven ... a 4 month-long project. The goal of the study ... families with free access to fresh produce and nutrition ... concerns like high blood pressure, diabetes and weight gain. ...
(Date:3/25/2015)... , March 25, 2015 /PRNewswire/ - SQI Diagnostics Inc. ... that, as a result of recent discussions with certain ... shares of the Company, after dealing with certain matters ... special meeting of shareholders on March 26, 2015 (the ... the election of directors will take place when the ...
Breaking Biology Technology:Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 2Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 3Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 4Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 5LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 2SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 4SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 5
... VANCOUVER, Oct. 31 /PRNewswire-FirstCall/ - Beanstalk Capital Ltd. ... to the Company,s press,release dated October 16, 2007, ... announced that they had entered into an arm,s ... Agreement"),the Company and iCo would now like to ...
... Corporation plc,(NASDAQ: AMRN ) ("Amarin" or the "Company") ... will present at the Acumen,BioFin Rodman & Renshaw 9th ... Eastern time. The conference will be held on November,5 ... The presentation will be simultaneously webcast and a ...
... Provides Revised Timing on Interim Celgosivir Viral Kinetics Study ... ... Oct. 31 /PRNewswire-FirstCall/ - MIGENIX Inc.,(TSX: MGI; OTC: MGIFF), a clinical-stage developer ... Renshaw 9th Annual,Healthcare Conference being held at the New York Palace Hotel ...
Cached Biology Technology:Beanstalk Capital Ltd. and iCo Therapeutics Inc. amend arrangement agreement 2Amarin Corporation to Present at Acumen BioFin Rodman & Renshaw Ninth Annual Healthcare Conference 2Amarin Corporation to Present at Acumen BioFin Rodman & Renshaw Ninth Annual Healthcare Conference 3MIGENIX to Present at the Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference 2MIGENIX to Present at the Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference 3
... protein size markers are a mixture of ... to 100 kDa. The markers provide precise ... after staining with Coomassie blue. Because each ... sequence, the markers can also be detected ...
Mouse monoclonal antibody to ACP2 - acid phosphatase 2, lysosomal...
... 220 V, is used for agitation and mixing ... staining and destaining of gels and blots, and ... (8-40 rpm) and can handle a maximum load ... two 29 x 21 cm platforms covered with ...
... (3-ethylbenzthiazoline-6-sulfonic Acid) Clear to very pale ... H 2 O 2 in a citrate ... that is soluble, safe, convenient and has good ... intense blue-green color that can be measured at ...
Biology Products: