Navigation Links
Carbon nanotubes boost cancer-fighting cells
Date:4/20/2010

New Haven, Conn.Yale University engineers have found that the defects in carbon nanotubes cause T cell antigens to cluster in the blood and stimulate the body's natural immune response. Their findings, which appear as the cover article of the April 20 issue of the journal Langmuir, could improve current adoptive immunotherapy, a treatment used to boost the body's ability to fight cancer.

Adoptive immunotherapy involves extracting a patient's blood so that the number of naturally occurring T cells (a type of white blood cell) can reproduce more effectively in the laboratory. Although the body produces its own tumor-fighting T cells, they are often suppressed by the tumor and are too few to be effective. Scientists boost the production of T cells outside the body using different substances that encourage T cell antigens to cluster in high concentrations. The better these substances are at clustering T cell antigens, the greater the immune cell proliferation. Once enough T cells are produced, the blood is transferred back into the patient's body.

The Yale team had previously reported the unexpected effect that carbon nanotubes had on T cell production. They found that the antigens, when presented on the surface of the nanotubes, stimulated T cell response far more effectively than coating other substrates such as polystyrene in the antigens, even though the total amount of antigens used remained the same.

Now they have discovered the reason behind the increased stimulation. They found that the antigens cluster in high concentrations around the tiny defects found in the carbon nanotubes.

"Carbon nanotube bundles resemble a lymph node microenvironment, which has a labyrinth sort of geometry," said Tarek Fahmy, associate professor of chemical engineering and biomedical engineering at Yale and senior author of the paper. "The nanotube bundles seem to mimic the physiology and adsorb more antigens, promoting a greater immunological response."

Current adoptive immunotherapy takes weeks to produce enough T cells, but lab tests showed that the nanotubes produced the same T cell concentration in just one-third the time, Fahmy said.

Carbon nanotubes can cause problems, such as an embolism, when used in the body. But this isn't the case when they are used in blood that has been extracted from the patient, Fahmy said. Next, the team will work on a way to effectively remove the carbon nanotubes from the blood before it is returned to the patient.

"We think this is a really interesting use of carbon nanotubes. It's a way to exploit the unique properties of this material for biological application in a safe way."


'/>"/>

Contact: Suzanne Taylor Muzzin
suzanne.taylormuzzin@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Related biology news :

1. New study warns limited carbon market puts 20 percent of tropical forest at risk
2. Mice use specialized neurons to detect carbon dioxide in the air
3. Researchers find new taste in fruit flies: carbonated water
4. Studying component parts of living cells with carbon nanotube cellular probes
5. New membrane strips carbon dioxide from natural gas faster and better
6. Green alga genome project catalogs carbon capture machinery
7. Hungry microbes share out the carbon in the roots of plants
8. Decline in uptake of carbon emissions confirmed
9. Study reveals that nitrogen fertilizers deplete soil organic carbon
10. US fires release large amounts of carbon dioxide
11. Wildfire drives carbon levels in northern forests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/14/2017)... WINSTON-SALEM, N.C. , Feb. 14, 2017  Wake ... FRY-shlog), M.D., as its new chief executive officer (CEO). ... succeeds CEO John D. McConnell , M.D., who ... new position at the Medical Center, after leading it ... oversee the full scope of Wake Forest Baptist,s academic ...
(Date:2/10/2017)... -- Research and Markets has announced the ... Scientific and Commercial Aspects" to their offering. ... Biomarkers play ... therapy for selection of treatment as well for monitoring the ... disease in modern medicine. Biochip/microarray technologies and next generation sequencing ...
(Date:2/8/2017)... (NASDAQ: AWRE ), a leading supplier of biometrics ... and year ended December 31, 2016. Revenue ... to $6.9 million in the same quarter last year. Operating ... compared to $2.6 million in the fourth quarter of 2015. ... million, or $0.02 per diluted share, which compares to $1.8 ...
Breaking Biology News(10 mins):
(Date:2/20/2017)... , ... February 20, 2017 , ... ... the re-launch of “Crosswalk Insight: Oncology™” (Crosswalk), a unique precision medicine knowledge visualization ... can now be accessed through Inspirata’s diagnostic cockpit and is downloadable as an ...
(Date:2/20/2017)... ... February 20, 2017 , ... PuraCath ... associated with peritoneal dialysis, announced today that it has published the result of ... in Peritoneal Dialysis International (PDI), the official Journal of the International Society ...
(Date:2/20/2017)...  Atrius Health and IBM (NYSE: IBM ... to develop a cloud based service designed to ... view of the multiple influences on an individual,s ... be designed to support shared decision making between ... nonprofit healthcare organization with 875 physicians caring for ...
(Date:2/18/2017)... ... February 17, 2017 , ... The BMT ... the Center for International Blood & Marrow Transplant Research (CIBMTR) will take place ... , The combined scientific sessions offer investigators, clinicians, laboratory technicians, clinical research ...
Breaking Biology Technology: