Navigation Links
Carbon monoxide may cause long-lasting heart damage
Date:1/29/2008

PROVIDENCE, R.I. Lack of oxygen isnt the only way that carbon monoxide (CO) damages the heart, say researchers at Rhode Island Hospital.

According to the findings of a new study, published in the January issue of Academic Emergency Medicine, CO also causes direct damage to the heart muscle, separate from the effects of oxygen deprivation, which reduces the hearts pumping capacity and permanently impairs cardiac function.

These findings suggest that heart damage caused by carbon monoxide may have long-lasting effects even after its been eliminated from the blood, making the diagnosis of carbon monoxide poisoning even more critical, said lead author Selim Suner, M.D., M.S., director of emergency preparedness and disaster medicine at Rhode Island Hospital.

While this research puts us one step in the right direction, there is still much more we need to know about the underlying mechanisms if we hope to someday develop targeted treatments, added Suner, whos also an associate professor of emergency medicine, surgery and engineering at The Warren Alpert Medical School of Brown University.

The study is the first to show that COs effect on heart muscle is unrelated to oxygen deprivation in the recovery phase, even when all CO is out of the system.

When inhaled, CO the leading cause of accidental poisoning deaths across the country displaces oxygen in the blood and deprives organs such as the heart, brain and other vital organs of life-sustaining oxygen. Based on previous studies, researchers have speculated that there may be other mechanisms besides oxygen deprivation that lead to CO-related heart damage, although these have not been clearly defined.

In the study, Suner and colleagues examined an animal model in which blood and other systemic factors were eliminated in order to determine the direct effects of CO on cardiac function in the recovery phase. This model used three groups: a control group; a nitrogen control group designed to induce oxygen deprivation; and a group exposed to a combination of CO and oxygen, which best simulates the environmental conditions of CO poisoning. The pressure generated in the left ventricle of the heart was used as an indicator of heart function.

Left ventricular-generated pressure was decreased in both the nitrogren control and CO groups compared to the control group. However, the group exposed to CO did not recover cardiac function including blood pressure to the extent that the nitogren control group did after treatment with 100 percent oxygen. These findings suggest that CO has an independent toxic effect on the heart separate from oxygen deprivation.

Known as the invisible killer, CO exposure is responsible for an estimated 15,000 emergency department visits and 500 unintentional deaths each year. It is an odorless, colorless gas produced by common household appliances that burn fuel, such as gasoline, oil and wood. When not properly ventilated or used incorrectly, CO emitted by these appliances can build up to dangerous levels. CO poisoning can be very difficult to diagnose, since its symptoms resemble those of the flu and other common illnesses. Pregnant women, children and the elderly are most susceptible to CO poisoning.


'/>"/>

Contact: Jessica Collins Grimes
jgrimes2@lifespan.org
401-432-1328
Lifespan
Source:Eurekalert

Related biology news :

1. New study warns limited carbon market puts 20 percent of tropical forest at risk
2. Mice use specialized neurons to detect carbon dioxide in the air
3. Researchers find new taste in fruit flies: carbonated water
4. Studying component parts of living cells with carbon nanotube cellular probes
5. New membrane strips carbon dioxide from natural gas faster and better
6. Green alga genome project catalogs carbon capture machinery
7. Hungry microbes share out the carbon in the roots of plants
8. Decline in uptake of carbon emissions confirmed
9. Study reveals that nitrogen fertilizers deplete soil organic carbon
10. US fires release large amounts of carbon dioxide
11. Wildfire drives carbon levels in northern forests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
(Date:3/18/2016)... March 18, 2016 --> ... Biometrics, ICT, Manned & Unmanned Vehicles, Physical infrastructure and Perimeter ... companies in the border security market and the continuing migration ... Europe has led visiongain to publish ... success. --> defence & security companies in ...
(Date:3/15/2016)... JERUSALEM , March 15, 2016 ... Jerusalem , the technology-transfer company of the Hebrew University, ... developer of remote sensing technology of various human biological ... funding, raising $2.0 million from private investors. ... technology, based on the detection of electromagnetic emissions from ...
Breaking Biology News(10 mins):
(Date:4/26/2016)... LOS ANGELES, Calif. (PRWEB) , ... April 27, ... ... Los Angeles office of Lewis Roca Rothgerber Christie LLP as an associate in ... and prosecuting U.S. and international electrical, mechanical and electromechanical patent applications. He has ...
(Date:4/26/2016)... ... 2016 , ... Heidelberg Instruments, a leader in design, development ... Volume Pattern Generator (VPG) line of lithography systems. The breakthrough VPG+ system is ... a solution for mid volume direct write lithography applications. It utilizes the ...
(Date:4/26/2016)... ... 26, 2016 , ... BioFactura, Inc ., a biopharmaceutical research and manufacturing ... Healthy investor interest drove significant oversubscription of the original $1.5M target. The funds ... the advanced preclinical stages. , Chief Executive Officer and President, Darryl Sampey ...
(Date:4/26/2016)... ... ... uBiome, the leading microbial genomics company, welcomes Neil Grimmer, Co-founder and Chairman ... co-founding Plum in 2007, Neil Grimmer was Vice President of Strategy and Innovation at ... of ideas, products, and brands, Grimmer has been at the forefront of launching more ...
Breaking Biology Technology: