Navigation Links
Carbon dioxide's new-found signalling role could be applied to blood flow, birth and deafness
Date:11/13/2013

New research reveals exactly how the body measures carbon dioxide and suggests that far from being a metabolic waste product, it could play a key role as a biological signalling molecule.

Researchers led by Professor Nick Dale in the School of Life Sciences at the University of Warwick have shown that the body senses carbon dioxide directly through the protein Connexin 26, which acts as a receptor for the gas. Connexin 26 is better known as forming a direct channel of communication between cells. This new work shows an unexpected function for Connexin 26 as a receptor for carbon dioxide.

The study demonstrates at a molecular level exactly how Connexin 26 interacts with carbon dioxide. This finding therefore adds carbon dioxide to the list of gaseous signalling molecules, such as nitric oxide, carbon monoxide and hydrogen sulphide already known to be active in mammals.

Given that Connexin 26 is found in many tissues and organs and, for example, mutations in it are the commonest genetic cause of deafness - the findings could have far-reaching effects as they open up potential new ways to control physiological processes such as brain blood flow, breathing, hearing, reproduction and birth.

Carbon dioxide is the by-product of metabolism in all cells. Dissolved carbon dioxide can combine with water to increase acidity in the blood. As mammals produce carbon dioxide at a fast rate, it is vital that the body measures its levels so that breathing rates can be adjusted to exhale excess carbon dioxide and thus regulate blood pH within the narrow limits compatible with life.

Until now the body's regulation of blood acid levels was thought to be triggered by measuring pH levels of the blood. However the new findings from Warwick indicate that the body can sense carbon dioxide levels directly through Connexin 26.

Professor Nick Dale said: "Carbon dioxide is the unavoidable by-product of our metabolic system - human be
'/>"/>

Contact: Luke Harrison
luke.harrison@warwick.ac.uk
University of Warwick
Source:Eurekalert

Page: 1 2

Related biology news :

1. Drilling for hydrocarbons can impact aquatic life
2. Companies close to reusing the greenhouse gas carbon dioxide
3. Lawrence Livermore researchers unveil carbon nanotube jungles to better detect molecules
4. Carbon storage recovers faster than plant biodiversity in re-growing tropical forests
5. Polycyclic aromatic hydrocarbons in smokeless tobacco products
6. U.Va. researcher: Methane out, carbon dioxide in?
7. Carbonation alters the minds perception of sweetness
8. Carbon farming schemes should consider multiple cobenefits
9. Extreme weather, climate and the carbon cycle
10. Soil carbon blowing in the wind
11. Tropical ecosystems regulate variations in Earths carbon dioxide levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)...  The 2014 Holiday Season may be the ... Market Intelligence reports that the long anticipated floodgates ... forecasts that intensifying demand for smart phones, tablets, ... drive a global market of 2.5 billion users ... According to Maxine Most ...
(Date:12/19/2014)... LAS VEGAS , Dec. 18, 2014   ... platform built for the post-password and Internet of Things ... additional seed funding. The venture round was led by ... Pantera Capital, Rimrock Venture Partners, VegasTechFund, and others.  LaunchKey ... the new funding to expand its team and bring ...
(Date:12/17/2014)... Dec. 16, 2014 Valencell, a leader in ... biometric technology to industry leaders such as Intel, Jabra, ... validated, biometric wearable products. These products will be showcased ... Las Vegas . "Our ... flexible and robust – with the clinical data to ...
Breaking Biology News(10 mins):First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... Illinois at Chicago College of Pharmacy are attempting ... antipsychotic medication works in adults and children and ... a popular "atypical" antipsychotic medication, is used to ... disorder. , Jeffrey Bishop, assistant professor of ...
... With wheat stem sawfly natural enemies in demand, ... increasing their availability. , This fall, the ... mass-rearing parasitic wasps that attack wheat stem sawfly ... plants. The team includes entomologists David Weaver, master's ...
... tool developed at Cambridge University represents a breakthrough in ... Huntington's disease. , Researchers have developed an effective ... the disease, using an automated touch screen. It is ... more effectively the cognitive difficulties in other neurodegenerative disorders ...
Cached Biology News:Studies look at how genes affect antipsychotic drug response 2Rearing an army to save wheat 2Rearing an army to save wheat 3New technology to speed up research into Huntington's disease 2New technology to speed up research into Huntington's disease 3
(Date:12/24/2014)... York (PRWEB) December 23, 2014 According to ... Long Island Affiliate of ITRA Global, the national office market ... steady recovery. This is evidenced by the third quarter’s ... stock market. Low energy costs have held inflation down ... only negative is the housing market remaining soft. , This ...
(Date:12/24/2014)... December 24, 2014 The report expects ... 19.7% by 2019. It also provides a carefully analyzed ... and challenges for the market. , Full Copy of ... report, the global market for cell expansion will keep ... It expects this growth to be driven by rapid ...
(Date:12/24/2014)... 23, 2014 Vermillion, Inc. (Nasdaq:   ... disease, announced today that investors including Oracle Investment ... LLC and several Vermillion directors have agreed to ... Vermillion,s common stock and warrants to purchase unregistered ... placement.  Under the terms of ...
(Date:12/24/2014)... SARASOTA, Fla. , Dec. 23, 2014  Rock ... today that it has filed a Clinical Trial Application ... Medicines Healthcare products Regulatory Agency (MHRA) seeking regulatory approval ... its lead molecule, Anatabine Citrate. Contingent on ... to conduct a Phase I trial to assess the ...
Breaking Biology Technology:ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3
... one Delaware man,s vision,comes true, Americans will become ... with breast cancer, and to get started on ... an awareness campaign in his home state this,month., ... Tumor Foundation,and early this month kicked off a ...
... Agreement with U.S. Attorney,s, Office for Eastern District of ... Settles State Cases with ... Cephalon, Inc. (Nasdaq:,CEPH) announced today it has finalized a ... for the Eastern District of,Pennsylvania, the U.S. Department of ...
... Publications --, BRITISH COLUMBIA, Canada, Sept. 29 ... VENTURE: IXS;, http://www.ixsbio.com ), a drug development company ... its Dynamic Cross Linking,(DXL(TM)) technology, announces Jeff Morhet, ... company also announces the featuring of,Mr. Morhet in ...
Cached Biology Technology:Delaware Man Spearheads Brain Tumor Awareness 2Cephalon Concludes All Outstanding Federal and State Government Investigations into the Company's Sales and Promotional Practices 2Cephalon Concludes All Outstanding Federal and State Government Investigations into the Company's Sales and Promotional Practices 3Cephalon Concludes All Outstanding Federal and State Government Investigations into the Company's Sales and Promotional Practices 4InNexus Biotechnology CEO to Present at BioContactQuebec 2008 2
Kanamycin is used for selection of resistant bacteria. C18H36N4O11xH2SO4. Contains 10 mg/ml kanamycin (base) utilizing kanamycin sulfate in 0.85% saline....
Request Info...
...
... Agarose-HR High Resolution - ... from 50 to 1000 ... for sizing PCR fragments, ... by restriction enzyme digestion, ...
Biology Products: