Navigation Links
Carbon dioxide's new-found signalling role could be applied to blood flow, birth and deafness
Date:11/13/2013

New research reveals exactly how the body measures carbon dioxide and suggests that far from being a metabolic waste product, it could play a key role as a biological signalling molecule.

Researchers led by Professor Nick Dale in the School of Life Sciences at the University of Warwick have shown that the body senses carbon dioxide directly through the protein Connexin 26, which acts as a receptor for the gas. Connexin 26 is better known as forming a direct channel of communication between cells. This new work shows an unexpected function for Connexin 26 as a receptor for carbon dioxide.

The study demonstrates at a molecular level exactly how Connexin 26 interacts with carbon dioxide. This finding therefore adds carbon dioxide to the list of gaseous signalling molecules, such as nitric oxide, carbon monoxide and hydrogen sulphide already known to be active in mammals.

Given that Connexin 26 is found in many tissues and organs and, for example, mutations in it are the commonest genetic cause of deafness - the findings could have far-reaching effects as they open up potential new ways to control physiological processes such as brain blood flow, breathing, hearing, reproduction and birth.

Carbon dioxide is the by-product of metabolism in all cells. Dissolved carbon dioxide can combine with water to increase acidity in the blood. As mammals produce carbon dioxide at a fast rate, it is vital that the body measures its levels so that breathing rates can be adjusted to exhale excess carbon dioxide and thus regulate blood pH within the narrow limits compatible with life.

Until now the body's regulation of blood acid levels was thought to be triggered by measuring pH levels of the blood. However the new findings from Warwick indicate that the body can sense carbon dioxide levels directly through Connexin 26.

Professor Nick Dale said: "Carbon dioxide is the unavoidable by-product of our metabolic system - human be
'/>"/>

Contact: Luke Harrison
luke.harrison@warwick.ac.uk
University of Warwick
Source:Eurekalert

Page: 1 2

Related biology news :

1. Drilling for hydrocarbons can impact aquatic life
2. Companies close to reusing the greenhouse gas carbon dioxide
3. Lawrence Livermore researchers unveil carbon nanotube jungles to better detect molecules
4. Carbon storage recovers faster than plant biodiversity in re-growing tropical forests
5. Polycyclic aromatic hydrocarbons in smokeless tobacco products
6. U.Va. researcher: Methane out, carbon dioxide in?
7. Carbonation alters the minds perception of sweetness
8. Carbon farming schemes should consider multiple cobenefits
9. Extreme weather, climate and the carbon cycle
10. Soil carbon blowing in the wind
11. Tropical ecosystems regulate variations in Earths carbon dioxide levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... Conn. , Jan. 28, 2015 NXT-ID, ... or the "Company"), a biometric authentication company focused on ... at the upcoming RedChip Global Online CEO Conference on ... Gino Pereira , CEO of NXT-ID ... its lead product, the Wocket smart wallet and its ...
(Date:2/5/2015)... JOLLA, Calif. , Jan. 30, 2015  It ... the great power and potential for genomic science as ... aid in disease prevention and treatment.  I was honored ... potential new, government-funded precision medicine program. ... advancing the science of genomics—from the first sequenced genome ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... "Biometrics - A Global Market Overview" report to their ... technology is to ensure that an individual is who she/he ... may make use of a person,s unique physical characteristics, such ...
Breaking Biology News(10 mins):CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3
... 2010⎯The old joke is a joke no more. In a ... Sciences Education ( CBE-LSE ), the adage that biology ... to rest forever. "Bio-math" or "math-bio" is in the future ... essays and 17 research articles on new ways to integrate ...
... the U.S. Department of Energy,s (DOE) Savannah River National ... will collaborate on radiation ecology research, including projects in ... Chernobyl Nuclear Power Plant 24 years ago. Researchers ... extensive laboratory for studying the effects of radioactive contamination ...
... study comparing a University of Pennsylvania method for ... traditional American method has shown that 80 percent of ... are actually at risk for developing osteoarthritis and hip ... indicate that traditional scoring of radiographs that certify dogs ...
Cached Biology News:You say, 'bio-math,' I say, 'math-bio': Crossing science education divide 2SRNL, Chernobyl Laboratory collaborate on research initiatives 2Hip dysplasia susceptibility in dogs may be underreported, according to Penn Vet comparative study 2Hip dysplasia susceptibility in dogs may be underreported, according to Penn Vet comparative study 3Hip dysplasia susceptibility in dogs may be underreported, according to Penn Vet comparative study 4
(Date:3/2/2015)... Shimadzu Scientific Instruments will showcase several new ... marijuana analysis at the Pittcon 2015 conference and exhibition. ... the Ernest N. Morial Convention Center in New Orleans, ... to discuss laboratory challenges with Shimadzu’s technical experts and ... save time, money and effort in the lab. ...
(Date:3/2/2015)... , March 2, 2015 VLP Therapeutics, ... biotechnology company focusing on the research and development ... antibody agents based upon a novel and proprietary ... Life Sciences Impact Grant Award from the Montgomery ... created by MCDED, is awarded to life sciences ...
(Date:3/2/2015)... -- Editor Note: For more information about ... Moments ago, Analysts Review released new research updates concerning several ... SSH ), Synergetics USA (NASDAQ: ... ), Spectranetics (NASDAQ: SPNC ), and Thoratec (NASDAQ: ... platform for investors, to hear about what matters - proudly ...
(Date:3/2/2015)... 02, 2015 Global Stem ... alliance with Shenzhen HANK Bioengineering Co., Ltd. and ... alliance will establish a stem cells training course ... in September 2015. , Shenzhen HANK is a ... award-winning scientist, microbiologist and virologist, to integrate research, ...
Breaking Biology Technology:Shimadzu Scientific Instruments Announces Product Launches, Presentations and Poster Sessions for Pittcon 2015 2Shimadzu Scientific Instruments Announces Product Launches, Presentations and Poster Sessions for Pittcon 2015 3VLP Therapeutics Wins the 2015 Life Sciences Impact Grant Award from the Montgomery County Department of Economic Development 2Quarterly Report Card of Biotechnology Companies: New Research on Sunshine Heart, Synergetics USA, Syneron Medical, Spectranetics and Thoratec 2Quarterly Report Card of Biotechnology Companies: New Research on Sunshine Heart, Synergetics USA, Syneron Medical, Spectranetics and Thoratec 3Quarterly Report Card of Biotechnology Companies: New Research on Sunshine Heart, Synergetics USA, Syneron Medical, Spectranetics and Thoratec 4Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 2Global Stem Cells Group Announces Alliance with HANK Bioengineering Co., Ltd. in Shenzhen, China 3
... 2011 ProteinSimple today introduced a revolutionary new system for ... is a complete reinvention of the Western Blot, and is ... time in 30 years, researchers have access to a completely ... Western Blot was invented in 1979 and to this day ...
... are wonderfully flexible as well as conductive. But those qualities ... A new study from Rice University finds gold ... stress. It appears in the journal Advanced Functional Materials. ... and his lab shows in microscopic detail what happens to ...
... KONG, Aug. 29, 2011 /PRNewswire-Asia-FirstCall/ -- China Cord Blood Corporation ... leading provider of cord blood collection, laboratory testing, hematopoietic stem ... preliminary unaudited financial results for the first quarter of fiscal ... First Quarter of Fiscal ...
Cached Biology Technology:ProteinSimple Reinvents the Western Blot 2Tiny wires change behavior at nanoscale 2China Cord Blood Corporation Reports Financial Results for the First Quarter of Fiscal 2012 2China Cord Blood Corporation Reports Financial Results for the First Quarter of Fiscal 2012 3China Cord Blood Corporation Reports Financial Results for the First Quarter of Fiscal 2012 4China Cord Blood Corporation Reports Financial Results for the First Quarter of Fiscal 2012 5China Cord Blood Corporation Reports Financial Results for the First Quarter of Fiscal 2012 6China Cord Blood Corporation Reports Financial Results for the First Quarter of Fiscal 2012 7China Cord Blood Corporation Reports Financial Results for the First Quarter of Fiscal 2012 8China Cord Blood Corporation Reports Financial Results for the First Quarter of Fiscal 2012 9China Cord Blood Corporation Reports Financial Results for the First Quarter of Fiscal 2012 10