Navigation Links
Carbon black nanoparticles can cause cell death
Date:5/18/2011

Researchers from the University of Iowa Roy J. and Lucille A. Carver College of Medicine have found that inhaled carbon black nanoparticles create a double source of inflammation in the lungs.

Their findings were published online in the April 27 edition of the Journal of Biological Chemistry. Martha Monick, Ph.D., UI professor of internal medicine, was lead author of the paper, "Induction of Inflammasome Dependent Pyroptosis by Carbon Black Nanoparticles," which outlined the results.

Monick said researchers expected to find one level of inflammation when cells were exposed to carbon black nanoparticles. They were surprised, however, to find that nanoparticles activated a special inflammatory process and killed cells in a way that further increased inflammation. She said the research showed that the intake of carbon black nanoparticles from sources such as diesel fuel or printer ink caused an initial inflammatory response in lung cells. The surprising results came when the team discovered that these nanoparticles killed macrophages immune cells in the lungs responsible for cleaning up and attacking infections in a way that also increases inflammation.

"Apoptosis is one way cells die in which all the contents stay in the cell, the cell just keeps shrinking onto itself and the surrounding tissue is protected," Monick said. "We thought that was what was happening with the carbon nanoparticles; we were wrong. A different process called pyroptosis was occurring, causing the cells to burst and spill their contents."

That, she said, can cause a secondary inflammatory response.

Monick cautioned that the doses of carbon black nanoparticles used in the study were much more concentrated than the amounts to which a person might typically be exposed.

"This doesn't mean that walking through a cloud of diesel exhaust will hurt your lungs," she said. "It does show that we may have an environmental exposure that could contribute to inflammation in the lung."


'/>"/>

Contact: Molly Rossiter
molly-rossiter@uiowa.edu
University of Iowa Health Care
Source:Eurekalert

Related biology news :

1. Antarctic icebergs help the ocean take up carbon dioxide
2. Consumption, carbon emissions and international trade
3. Report: Direct removal of carbon dioxide from air likely not viable
4. WHRC debuts detailed maps of forest canopy height and carbon stock for the conterminous US
5. Researchers create functioning synapse using carbon nanotubes
6. When it comes to carbon footprints, location and lifestyle matter
7. Carbon sequestration estimate in US increased -- barring a drought
8. Scots carbon emissions could be halved in decades, study suggests
9. Mangroves among the most carbon-rich forests in the tropics
10. Nature paper calls for carbon labeling
11. Antarctic icebergs play a previously unknown role in global carbon cycle, climate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/21/2017)... Ore. , Feb. 22, 2017  IBM (NYSE: ... (Avamere Health Services, Infinity Rehab, Signature Hospice, Home Health, ... will apply the power of IBM cognitive computing to ... centers. By analyzing data streaming from sensors in senior ... and environmental conditions, and obtain deeper learnings into the ...
(Date:2/13/2017)... FRANCISCO , Feb. 13, 2017  RSA ... centralized platform that is designed to enhance fraud ... latest release in the RSA Fraud & Risk ... enable organizations to leverage additional insights from internal ... tools to better protect their customers from targeted ...
(Date:2/8/2017)... YORK , Feb. 8, 2017 About ... individual,s voice to match it against a stored ... such as pitch, cadence, and tone are compared ... require minimal hardware installation, as most PCs already ... for different transactions. Voice recognition biometrics are most ...
Breaking Biology News(10 mins):
(Date:2/24/2017)... China Biologic Products, Inc. (NASDAQ: CBPO) ("China Biologic" or the ... today announced its financial results for the fourth quarter and ... Financial Highlights Total sales in the ... or increased by 13.6% in USD terms to $77.6 million ... Gross profit increased by 13.3% to $46.8 million ...
(Date:2/23/2017)... ... February 23, 2017 , ... BellBrook ... portfolio to include an array of biochemical analyses critical for Lead Discovery. ... their hit-to-lead and SAR programs, including inhibitor potency and selectivity, mechanism of action, ...
(Date:2/23/2017)... , Feb. 23, 2017  Imanis Life Sciences ... line of oncolytic vaccinia viruses for virotherapy research. ... part of Genelux,s proprietary, vaccinia virus-based technology platform ... to enter into a partnership with Genelux to ... vaccinia viruses for use in research," said Dr. ...
(Date:2/23/2017)... ... 2017 , ... The Greater Gift Initiative, Inc , (GGI) a Winston-Salem, ... . GGI's mission is to advance global health and highlight the greater good of ... of each clinical trial volunteer. The vision of GGI is to serve as a ...
Breaking Biology Technology: